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3-METHYLCHOLANTHRENE

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Name

3-METHYLCHOLANTHRENE

EINECS 200-276-4
CAS No. 56-49-5 Density 1.223 g/cm3
PSA 0.00000 LogP 5.55320
Solubility

Stability

    Stable. Combustible. Incompatible with strong oxidizing agents.

Toxicology

    Harmful if swallowed or inhaled and in contact with the skin.May cause reproductive harm. May act as a carcinogen. Serio
Melting Point 178-180ºC
Formula C21H16 Boiling Point 280 ºC 80 mm Hg(lit.)
Molecular Weight 268.358 Flash Point -5ºC
Transport Information N/A Appearance yellow crystalline solid
Safety Suspected carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intravenous and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Risk Codes 45-36-20/21/22-11
Molecular Structure Molecular Structure of 56-49-5 (3-METHYLCHOLANTHRENE) Hazard Symbols Powerful carcinogen.
Synonyms

Cholanthrene,3-methyl- (8CI); 20-MC; 20-Methylcholanthrene; 3-MC; 3-Methylcholanthrene; MCA;Methylcholanthrene; NSC 21970

Article Data 23

3-METHYLCHOLANTHRENE Synthetic route

78606-95-8

6-acetoxy-3-methylcholanthrene

56-49-5

methylcholanthrene

Conditions
ConditionsYield
With hydrogen iodide; hypophosphorous acid In propionic acid for 0.166667h; Heating;93%
102549-05-3

3ξ-(2-amino-phenyl)-2-(8-methyl-acenaphthen-3-yl)-acrylic acid

56-49-5

methylcholanthrene

Conditions
ConditionsYield
With 1,4-dioxane; sulfuric acid; isopentyl nitrite Reagens 4: Aethanol; anschliessendes Erwaermen mit Kupfer-Pulver und danach Erhitzen mit basischem Kupfer(II)-acetat unter vermindertem Druck;
5676-40-4

3α,7α-diacetoxy-12-one-5β-cholan-24-oic acid

56-49-5

methylcholanthrene

Conditions
ConditionsYield
at 320 - 340℃; Behandlung des Reaktionsprodukts mit Selen bei 320-340grad;
855740-55-5

3-methyl-2,2a,3,4-tetrahydro-1H-benz[j]aceanthrylen-5-one

56-49-5

methylcholanthrene

Conditions
ConditionsYield
With hydrogenchloride; amalgamated zinc Erhitzen des Reaktionsprodukts mit Platin/Kohle auf 280grad;
2458-08-4

3α,7α-dihydroxy-12-oxo-5β-cholan-24-oic acid

56-49-5

methylcholanthrene

Conditions
ConditionsYield
at 320 - 340℃; Behandlung des Reaktionsprodukts mit Selen bei 320-340grad;
100260-10-4

3-methyl-1,2,2a,3,4,5-hexahydro-benz[j]aceanthrylene

56-49-5

methylcholanthrene

Conditions
ConditionsYield
With selenium at 320 - 340℃;
63665-87-2

(7-methyl-indan-4-yl)-[1]naphthyl ketone

56-49-5

methylcholanthrene

Conditions
ConditionsYield
at 405 - 410℃;
859983-50-9

(4-methoxy-[1]naphthyl)-(7-methyl-indan-4-yl)-ketone

56-49-5

methylcholanthrene

Conditions
ConditionsYield
at 400℃;

(2,7-dimethyl-indan-4-yl)-[1]naphthyl ketone

A

56-49-5

methylcholanthrene

B

63041-61-2

1,3-dimethyl-cholanthrene

Conditions
ConditionsYield
at 405 - 410℃;
859962-13-3

(4-chloro-[1]naphthyl)-(7-methyl-indan-4-yl)-ketone

A

56-49-5

methylcholanthrene

B

63041-38-3

11-chloro-3-methyl-cholanthrene

Conditions
ConditionsYield
at 410℃;

3-METHYLCHOLANTHRENE Chemical Properties

MF: C21H16
MW: 268.35
EINECS: 200-276-4
3-METHYLCHOLANTHRENE.it's melting point is   178-180 °C(lit.);boiling point is  280 °C at 80 mm Hg(lit.) .It's appearance is yellow crystals.
Following is the molecular structure of 3-METHYLCHOLANTHRENE:

3-METHYLCHOLANTHRENE Toxicity Data With Reference

1.   

otr-hmn:lng 500 μg/L/2W

   GANNA2    Gann. Japanese Journal of Cancer Research. 74 (1983),615.
2.   

sce-hmn:fbr 1 mmol/L

   MUREAV    Mutation Research. 117 (1983),47.
3.   

orl-rat TDLo:600 mg/kg (MGN):CAR,TER

   CNREA8    Cancer Research. 12 (1952),296.
4.   

orl-rat TDLo:600 mg/kg (female 60D pre):CAR

   CNREA8    Cancer Research. 12 (1952),296.
5.   

orl-rat TDLo:600 mg/kg (multi) :CAR

   CNREA8    Cancer Research. 12 (1952),296.
6.   

orl-mus TDLo:21 mg/kg (15-17D post):CAR,TER

   TXAPA9    Toxicology and Applied Pharmacology. 72 (1984),427.
7.   

skn-mus TDLo:120 mg/kg (MGN):CAR,TER

   BEXBAN    Bulletin of Experimental Biology and Medicine. Translation of BEBMAE. 71 (1971),677.
8.   

ipr-mus TDLo:5 mg/kg (17D post):CAR,TER

   CRNGDP    Carcinogenesis. 6 (1985),1389.
9.   

ipr-mus LDLo:100 mg/kg

   TXAPA9    Toxicology and Applied Pharmacology. 23 (1972),288.
10.   

irn-frg LDLo:9 mg/kg

   CNREA8    Cancer Research. 24 (1964),1969.

3-METHYLCHOLANTHRENE Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

3-METHYLCHOLANTHRENE Safety Profile

Suspected carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intravenous and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Hazard Codes:  T,Xn,F (Toxic;Harmful;Highly Flammable)
Risk Statements:
   R45-36-20/21/22-11 (May cause cancer ;Irritating to the eyes ;Harmful by inhalation, in contact with skin and if swallowed Highly Flammable )
Safety Statements  :
   S53-36/37/39-45-26-16 (Avoid exposure - obtain special instruction before use ;Wear suitable protective clothing, gloves and eye/face protection;  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) ;In case of contact with eyes, rinse immediately with plenty of water and seek medical advice  ;Keep away from sources of ignition - No smoking)

3-METHYLCHOLANTHRENE Specification


HANDLING and STORAGE about 3-METHYLCHOLANTHRENE:
Handling:
   Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Do not get on skin and clothing. Do not ingest or inhale. Use with adequate ventilation. Do not breathe dust.
Storage:
    Store in a tightly closed container. Store in a cool, dry,well-ventilated area away from incompatible substances.storage temp:2-8°C

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