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Name |
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide |
EINECS | 615-805-8 |
CAS No. | 72811-73-5 | Density | 1.357 g/cm3 |
PSA | 93.46000 | LogP | 3.63510 |
Solubility | N/A | Melting Point |
162-164oC |
Formula | C12H13N3O2S | Boiling Point | 475.8 °C at 760 mmHg |
Molecular Weight | 263.32 | Flash Point | 241.5 °C |
Transport Information | N/A | Appearance | N/A |
Safety | 26 | Risk Codes | 36 |
Molecular Structure | Hazard Symbols | Xi | |
Synonyms |
3-Sulfonamido-4-(3-methylanilino)pyridine;BM 960102;4-(3-methylphenyl)amino-3-pyridine sulfonamide; |
Article Data | 5 |
4-chloropyridine-3-sulphonamide
1-amino-3-methylbenzene
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
Conditions | Yield |
---|---|
In methanol at 39.85℃; for 3h; | 96.5% |
In propan-1-ol for 5h; Heating; | |
In water at 80 - 90℃; for 1 - 1.5h; Product distribution / selectivity; | |
Stage #1: 4-chloropyridine-3-sulphonamide; 1-amino-3-methylbenzene In water for 0.5h; Heating / reflux; Stage #2: With sodium hydroxide In water at 20 - 35℃; Stage #3: With sulfuric acid In water Product distribution / selectivity; |
4-chloro-3-pyridinesulfonamide hydrochloride
1-amino-3-methylbenzene
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
Conditions | Yield |
---|---|
Stage #1: 4-chloro-3-pyridinesulfonamide hydrochloride; 1-amino-3-methylbenzene In water at 90℃; for 3h; Stage #2: With sodium hydrogencarbonate In water at 20℃; pH=7 - 8; | 92% |
3-Iodotoluene
3-sulfonamido-4-aminopyridine
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
Conditions | Yield |
---|---|
With copper; potassium carbonate In butan-1-ol | 53.1% |
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
Isopropyl isocyanate
Conditions | Yield |
---|---|
Stage #1: 3-sulfonamido-4-(3'-methylphenyl) aminopyridine With sodium hydride In tetrahydrofuran; toluene at 5 - 20℃; for 16h; Stage #2: Isopropyl isocyanate In tetrahydrofuran; toluene at 20℃; Stage #3: Isopropyl isocyanate With sodium hydride; acetic acid more than 3 stages; | 100% |
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
Isopropyl isocyanate
torasemide
Conditions | Yield |
---|---|
Stage #1: 3-sulfonamido-4-(3'-methylphenyl) aminopyridine; Isopropyl isocyanate With potassium carbonate In diethylene glycol dimethyl ether; water at 65 - 70℃; for 0.583333h; Stage #2: With acetic acid In diethylene glycol dimethyl ether; water at 20 - 25℃; for 3h; pH=5.3 - 5.7; | 96.5% |
Stage #1: 3-sulfonamido-4-(3'-methylphenyl) aminopyridine; Isopropyl isocyanate With sodium hydroxide In acetone at 20 - 30℃; Stage #2: With acetic acid In water; acetone at 20 - 25℃; for 0.25h; pH=5.3 - 5.7; | 96% |
Stage #1: 3-sulfonamido-4-(3'-methylphenyl) aminopyridine; Isopropyl isocyanate With sodium hydroxide In acetone at 20 - 30℃; Stage #2: With acetic acid In water; acetone at 20 - 25℃; for 0.25h; pH=5.5; | 96% |
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
Isopropyl isocyanate
Conditions | Yield |
---|---|
With sodium hydroxide In acetone at 5 - 20℃; for 2h; Reagent/catalyst; | 94.5% |
phenyl N-isopropylcarbamate
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
torasemide
Conditions | Yield |
---|---|
Stage #1: phenyl N-isopropylcarbamate; 3-sulfonamido-4-(3'-methylphenyl) aminopyridine With triethylamine In water; acetone for 3h; Heating / reflux; Stage #2: With sodium hydroxide In water at 20 - 25℃; Stage #3: With sulfuric acid In water; acetone at 50 - 55℃; for 1h; Product distribution / selectivity; | 87.8% |
Stage #1: phenyl N-isopropylcarbamate; 3-sulfonamido-4-(3'-methylphenyl) aminopyridine With sodium hydroxide In water at 90 - 100℃; for 5h; Stage #2: With sulfuric acid In water at 20 - 70℃; for 1h; Product distribution / selectivity; | 85% |
Stage #1: 3-sulfonamido-4-(3'-methylphenyl) aminopyridine With sodium hydroxide In water at 20 - 35℃; Stage #2: phenyl N-isopropylcarbamate In water; acetone at 50 - 60℃; for 20h; Stage #3: With sulfuric acid In water at 15 - 50℃; for 3h; pH=7.0; Product distribution / selectivity; |
chloroformic acid ethyl ester
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
[4-(3-methyl-anilino)-pyridine-3-sulfonyl]-carbamic acid ethyl ester
Conditions | Yield |
---|---|
With pyridine for 0.333333h; Heating; | 75% |
In tetrahydrofuran for 8h; Ambient temperature; |
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
N-cyano-N'-isopropyl-S-methylcarbamimidothioate
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane; N,N-dimethyl-formamide for 6h; Heating; | 37% |
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 75 percent / pyridine / 0.33 h / Heating 2: 37 percent / toluene / 5 h / Heating View Scheme |
Empirical Formula: C12H13N3O2S
Molecular Weight: 263.3155g/mol
Structure of 3-Pyridinesulfonamide,4-[(3-methylphenyl)amino]- (CAS NO.72811-73-5):
Index of Refraction: 1.641
Molar Refractivity: 69.97 cm3
Molar Volume: 193.9 cm3
Polarizability: 27.73×10-24cm3
Surface Tension: 63.3 dyne/cm
Density: 1.357 g/cm3
Flash Point: 241.5 °C
Enthalpy of Vaporization: 73.94 kJ/mol
Boiling Point: 475.8 °C at 760 mmHg
Vapour Pressure: 3.23E-09 mmHg at 25°C
Product Categories: INTERMEDIATESOFTORASEMIDE;Pyridines derivates;(intermediate of torasemide);Pyridines;Torsemide
Systematic Name: 4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
SMILES: O=S(=O)(c2c(Nc1cc(ccc1)C)ccnc2)N
InChI: InChI=1/C12H13N3O2S/c1-9-3-2-4-10(7-9)15-11-5-6-14-8-12(11)18(13,16)17/h2-8H,1H3,(H,14,15)(H2,13,16,17)
InChIKey: ZXPCUGWAKUIOOF-UHFFFAOYAX
3-Pyridinesulfonamide,4-[(3-methylphenyl)amino]- , its cas register number is 72811-73-5. It also can be called ; 4-[(3-Methylphenyl)amino]pyridine-3-sulfonamide ; 3-Sulfonamido-4-(3-methylanilino)pyridine ; 4-(3-Methylphenyl)amino-3-Pyridine Sulfonamide ; 4-(3-toluidino)pyridine-3-sulfonamide .