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Cas Database |
| Name |
4,4'-(Hexafluoroisopropylidene)diphenol |
EINECS | 216-036-7 |
| CAS No. | 1478-61-1 | Density | 1.447 g/cm3 |
| PSA | 40.46000 | LogP | 4.50850 |
| Solubility | Insoluble in water. | Melting Point |
160-163 °C(lit.) |
| Formula | C15H10F6O2 | Boiling Point | 344.1 °C at 760 mmHg |
| Molecular Weight | 336.234 | Flash Point | 161.9 °C |
| Transport Information | N/A | Appearance | White to off-white powder |
| Safety | 26-36-37/39 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
Phenol,4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]di- (6CI,7CI);1,1,1,3,3,3-Hexafluoro-2,2-bis(4-hydroxyphenyl)propane;2,2-Bis(4-hydroxyphenyl)hexafluoropropane;BIS-AF;Bisphenol AE;Cheminox BAF;GP 21;Hexafluorobisphenol A;Hexafluoroisopropylidenebis(4-hydroxybenzene);NSC152522; |
Article Data | 13 |
4,4'-(Hexafluoroisopropylidene)diphenol Synthetic route
| Conditions | Yield |
|---|---|
| With TiClF3; SbF4Cl; hydrogen fluoride for 12h; Reagent/catalyst; Autoclave; | 97.3% |
| With hydrogen fluoride; antimonypentachloride; titanium tetrachloride at 55℃; for 12h; Reagent/catalyst; Autoclave; | 97.5% |
| Conditions | Yield |
|---|---|
| With hydrogen fluoride In melt at 10 - 100℃; for 2h; Temperature; Autoclave; | 95% |
| With hydrogen fluoride | |
| surface-bound sulfonic acid-containing material at 90℃; for 24h; |
- 144820-54-2
hexachlorobisphenol A
- 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol
| Conditions | Yield |
|---|---|
| With hydrogen fluoride; triethylamine at 10 - 100℃; for 6h; Reagent/catalyst; Temperature; Inert atmosphere; | 92.8% |
| Conditions | Yield |
|---|---|
| With hydrogen fluoride at 110℃; under 7125.71 Torr; for 6h; Autoclave; | 82% |
- 79-37-8
oxalyl dichloride
- 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol
- 335148-89-5
bisphenol AF bisoxalyl chloride adduct
| Conditions | Yield |
|---|---|
| In 1,2-dichloro-ethane at 90℃; for 6h; Heating / reflux; | 100% |
| Conditions | Yield |
|---|---|
| Stage #1: 4,4'-(hexafluoroisopropylidene)diphenol With potassium carbonate In acetone at 23℃; for 0.5h; Stage #2: prenyl bromide In acetone at 23℃; for 16h; | 100% |
| Conditions | Yield |
|---|---|
| Stage #1: 4,4'-(hexafluoroisopropylidene)diphenol With potassium carbonate In N,N-dimethyl acetamide; toluene for 2h; Reflux; Stage #2: 1-chloro-2,4-dinitro-benzene at 90℃; for 5h; | 98.3% |
- 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol
- 35375-74-7
5-chloro-2-nitro-4-(trifluoromethyl)aniline
| Conditions | Yield |
|---|---|
| With potassium carbonate In dimethyl sulfoxide at 80℃; for 0.0833333h; Sonication; | 98% |
| Conditions | Yield |
|---|---|
| With copper(l) iodide; 1,10-Phenanthroline; potassium carbonate In N,N-dimethyl-formamide; toluene at 135 - 145℃; Ullmann reaction; | 97% |
- 126531-39-3
2,2-bis[4-(4-hydroxyphenyl)phenyl]propane
- 32315-10-9
bis(trichloromethyl) carbonate
- 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol
| Conditions | Yield |
|---|---|
| With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane at 0 - 15℃; for 1h; | 97% |
4,4'-(Hexafluoroisopropylidene)diphenol Chemical Properties
Molecular Formula: C15H10F6O2
Molecular Weight: 336.23
EINECS: 216-036-7
Index of Refraction: 1.506
Molar Refractivity: 69.08 cm3
Molar Volume: 232.3 cm3
Surface Tension: 35.4 dyne/cm
Density: 1.447 g/cm3
Flash Point: 161.9 °C
Enthalpy of Vaporization: 61.13 kJ/mol
Boiling Point: 344.1 °C at 760 mmHg
Vapour Pressure: 3.38E-05 mmHg at 25 °C
Melting point: 160-163 °C(lit.)
Appearance: White to off-white powder
Structure of Hexafluorobisphenol A (CAS NO.1478-61-1):
IUPAC Name: 4-[1,1,1,3,3,3-Hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenol
Canonical SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)O)(C(F)(F)F)C(F)(F)F)O
InChI: InChI=1S/C15H10F6O2/c16-14(17,18)13(15(19,20)21,9-1-5-11(22)6-2-9)10-3-7-12(23)8-4-10/h1-8,22-23H
InChIKey: ZFVMWEVVKGLCIJ-UHFFFAOYSA-N
Product Category of Hexafluorobisphenol A (CAS NO.1478-61-1): Organic Fluorides;Bisphenol AF type Compounds (for High-Performance Polymer Research);Functional Materials
4,4'-(Hexafluoroisopropylidene)diphenol Toxicity Data With Reference
| 1. | mnt-ham-lng 50 µmol/L | MUREAV Mutation Research. 390 (1997),21. | ||
| 2. | orl-rat LD50:3400 mg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0555704 . |
4,4'-(Hexafluoroisopropylidene)diphenol Safety Profile
Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic vapors of F−.
Hazard Codes: 
Xi
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36-37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection
WGK Germany: 2
RTECS: SN2780000
Hazard Note: Corrosive
4,4'-(Hexafluoroisopropylidene)diphenol Specification
Hexafluorobisphenol A , its cas register number is 1478-61-1. It also can be called Bisphenol AF ; Hexafluoroisopropylidenebis(4-hydroxybenzene) ; and 4,4'-(Hexafluoroisopropylidene)diphenol . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, Hexafluorobisphenol A (CAS NO.1478-61-1) could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, strong reducing agents, strong acids, strong bases, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: Carbon monoxide, carbon dioxide, hydrogen fluoride gas.
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