IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. Community Right-To-Know List.

OSHA PEL: CL 0.02 ppm
ACGIH TLV: 0.005 ppm
DFG MAK: 0.05 mg/m³; Confirmed Animal Carcinogen with Unknown Relevance to Humans
NIOSH REL: (Diisocyanates) TWA 0.005 ppm; CL 0.02 ppm/10M
DOT Classification:  6.1; Label: KEEP AWAY FROM FOOD; DOT Class: 6.1; Label: Poison; DOT Class: 6.1; Label: Poison, Flammable Liquid; DOT Class: 3; Label: Flammable Liquid, Poison

For occupational chemical analysis use OSHA: #18, superseded by #47.

The 4,4'-Diphenylmethane diisocyanate, with the cas registry number 101-68-8, has the IUPAC name of 1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene. Following are the basic information of this chemical: This chemical is a kind of white to light yellow flakes or crystals with strong irritating odour, and is not soluble in water while soluble in acetone, benzene, kerosene and nitrobenzene. Its product categories are various, including diphenylmethanes (for high-performance polymer research); functional materials; reagent for high-performance polymer research; alphabetic; m; meta - meth. Besides, it is sensitive and is incompatible with strong oxidizing agents. When store it, keep it in the dry, cool and well-ventilated storeroom, away from the containing water products, alcohol and amine products.

The characteristics of 4,4'-Diphenylmethane diisocyanate are as follows:
 (1)ACD/LogP: 4.94; (2)ACD/LogD (pH 5.5): 4.93; (3)ACD/LogD (pH 7.4): 4.93; (4)ACD/BCF (pH 5.5): 3314.7; (5)ACD/BCF (pH 7.4): 3314.7; (6)ACD/KOC (pH 5.5): 11522.03; (7)ACD/KOC (pH 7.4): 11522.03; (8)#H bond acceptors: 4; (9)#Freely Rotating Bonds: 4; (10)Polar Surface Area: 58.86 ; (11)Index of Refraction: 1.587; (12)Molar Refractivity: 74.38 cm³; (13)Molar Volume: 221 cm³; (14)Polarizability: 29.49 ×10^-24 cm³; (15)Surface Tension: 45.6 dyne/cm; (16)Density: 1.13 g/cm³; (17)Flash Point: 154 °C; (18)Enthalpy of Vaporization: 62.06 kJ/mol; (19)Boiling Point: 373.4 °C at 760 mmHg; (20)Vapour Pressure: 9.02E-06 mmHg at 25°C; (21)Exact Mass: 250.074228; (22)MonoIsotopic Mass: 250.074228; (23)Topological Polar Surface Area: 58.9; (24)Heavy Atom Count: 19; (25)Complexity: 332.

Production method of 4,4'-Diphenylmethane diisocyanate is as below:
 4,4'-methanediyl-bis-aniline could react with carbonic acid bis-trichloromethyl ester to produce bis-(4-isocyanato-phenyl)-methane, with the following condition: reaction time: 2 hours; reaction temp.: 130 ℃; yield: 92%.

Use of 4,4'-Diphenylmethane diisocyanate:
 Methylene bisphenyl isocyanate could react with 2-trimethylsilanyloxy-ethylamine to produce 2-Trimethylsiloxyaethylisocyanat, with the following condition: reaction temp.: 200 ℃; yield: 84%.

As to its usage, it is widely used in many ways. It could be used in producing PU Elastomers, synthetic fibre, artificial leather, and solventless coatings; It could also be used as the adhesives in the rubber and plastic industry.

Safety information of 4,4'-Diphenylmethane diisocyanate:
While dealing with this chemical, you should be very cautious. It is irritating to eyes, respiratory system and skin, and may cause sensitisation by inhalation and skin contact; Besides being a kind of toxic chemical, it may at low levels cause damage to health; Then it may also destroy living tissue on contact for it is corrosive. Therefor, you should take the following instructions. Wear suitable protective clothing and gloves and do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer). If in case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Additionally, the following datas could be converted into the molecular structure:
(1)SMILES:O=C=N\c1ccc(cc1)Cc2ccc(\N=C=O)cc2
(2)InChI:InChI=1/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2
(3)InChIKey:UPMLOUAZCHDJJD-UHFFFAOYAD

Below are the toxicity informatin of 4,4'-Diphenylmethane diisocyanate :

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TCLo	inhalation	130ppb/30M (0.13ppm)	IMMUNOLOGICAL INCLUDING ALLERGIC: INCREASED IMMUNE RESPONSE	American Industrial Hygiene Association Journal. Vol. 27, Pg. 121, 1966.
mouse	LD50	oral	2200mg/kg (2200mg/kg)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 63, 1982.
rat	LC50	inhalation	178mg/m3 (178mg/m3)		American Industrial Hygiene Association Journal. Vol. 43, Pg. 89, 1982.
rat	LD50	oral	9200mg/kg (9200mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	National Technical Information Service. Vol. OTS0516728