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Cas Database |
| Name |
4,4'-Methylene bis(2-chloroaniline) |
EINECS | 202-918-9 |
| CAS No. | 101-14-4 | Density | 1.354 g/cm3 |
| PSA | 52.04000 | LogP | 4.91100 |
| Solubility | <0.1 g/100 mL at 25 °C in water | Melting Point |
102-107 °C(lit.) |
| Formula | C13H12Cl2N2 | Boiling Point | 412 °C at 760 mmHg |
| Molecular Weight | 267.158 | Flash Point | 203 °C |
| Transport Information | UN 2018 | Appearance | off-white powder with slight odor |
| Safety | 53-45-60-61 | Risk Codes | 45-22-50/53-53-50 |
| Molecular Structure |
|
Hazard Symbols |
 T, N
|
| Synonyms |
Aniline,4,4'-methylenebis[2-chloro- (6CI,8CI);2,2'-Dichloro-4,4'-methylenedianiline;3,3'-Dichloro-4,4'-diaminodiphenylmethane;4,4'-Methylenebis(2-chloraniline);4,4'-Methylenebis(2-chlorobenzenamine);4,4'-Methylenebis[2-chloroaniline];4,4'-Methylenebis[o-chloroaniline];Bis(3-chloro-4-aminophenyl)methane;Bis(4-amino-3-chlorophenyl)methane;Bisamine A;Bisamine S;MOCA (curing agent);Methylenebis(3-chloro-4-aminobenzene);Methylenebis(chloraniline);Millionate M;NSC 52954;Pandex E;Pandex M 3202;Quodorole;SL 4037; |
Article Data | 16 |
4,4'-Methylene bis(2-chloroaniline) Chemical Properties
Molecular structure of 4,4'-Methylene bis(2-chloroaniline) (CAS NO.101-14-4) is:
Product Name: 4,4'-Methylene bis(2-chloroaniline)
CAS Registry Number: 101-14-4
IUPAC Name: 4-[(4-amino-3-chlorophenyl)methyl]-2-chloroaniline
Molecular Weight: 267.15378 [g/mol]
Molecular Formula: C13H12Cl2N2
XLogP3: 3.8
H-Bond Donor: 2
H-Bond Acceptor: 2
Melting Point: 102-107 °C(lit.)
Surface Tension: 56.8 dyne/cm
Density: 1.354 g/cm3
Flash Point: 203 °C
Enthalpy of Vaporization: 66.46 kJ/mol
Boiling Point: 412 °C at 760 mmHg
Vapour Pressure: 5.35E-07 mmHg at 25°C
Water Solubility: <0.1 g/100 mL at 25 °C
Stability: Stable, but decomposes exothermically, and possibly explosively, above 200 C. Incompatible with strong oxidizing agents.
4,4'-Methylene bis(2-chloroaniline) Uses
4,4'-Methylene bis(2-chloroaniline) (CAS NO.101-14-4) is used as pouring polyurethane rubber vulcanization agent, also can be used for curing epoxy resin.
4,4'-Methylene bis(2-chloroaniline) Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | oral | 400mg/kg (400mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(6), Pg. 86, 1990. |
| mouse | LD50 | intraperitoneal | 64mg/kg (64mg/kg) | Progress in Mutation Research. Vol. 1, Pg. 682, 1981. | |
| mouse | LD50 | oral | 640mg/kg (640mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(6), Pg. 86, 1990. |
| rabbit | LD50 | skin | > 5gm/kg (5000mg/kg) | "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 6, Pg. 988, 1991. | |
| rat | LD50 | oral | 1140mg/kg (1140mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(6), Pg. 86, 1990. |
| rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Naturwissenschaften. Vol. 58, Pg. 578, 1971. | |
| rat | LDLo | unreported | 1gm/kg (1000mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: CYANOSIS KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | American Industrial Hygiene Association Journal. Vol. 32, Pg. 802, 1971. |
4,4'-Methylene bis(2-chloroaniline) Consensus Reports
NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 246.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 4 ,1974,p. 65.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program. Community Right-To-Know List. Reported in EPA TSCA Inventory.
4,4'-Methylene bis(2-chloroaniline) Safety Profile
Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion and intraperitoneal routes. Mutation data reported. Flammable liquid. Reactive with active metals such as sodium, potassium, magnesium, or zinc. When heated to decomposition it emits very toxic fumes of Cl? and NOx. See also AMINES.
Hazard Codes: 
T,
N
Risk Statements: 45-22-50/53-53-50
R45:May cause cancer.
R22:Harmful if swallowed.
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R53:May cause long-term adverse effects in the aquatic environment.
R50:Very toxic to aquatic organisms.
Safety Statements: 53-45-60-61
S53:Avoid exposure - obtain special instructions before use.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S60:This material and its container must be disposed of as hazardous waste.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 3077 9/PG 3
WGK Germany: 3
RTECS: CY1050000
HazardClass: 6.1(b)
PackingGroup: III
4,4'-Methylene bis(2-chloroaniline) Standards and Recommendations
OSHA PEL: TWA 0.02 ppm (skin)
ACGIH TLV: TWA 0.01 ppm; Suspected Human Carcinogen
DFG MAK: Animal Carcinogen, Suspected Human Carcinogen
NIOSH REL: (MOCA): TWA 0.003 mg/m3 (Skin)
4,4'-Methylene bis(2-chloroaniline) Analytical Methods
For occupational chemical analysis use OSHA: #24 or NIOSH: MBOCA in Urine, 8302.
4,4'-Methylene bis(2-chloroaniline) Specification
4,4'-Methylene bis(2-chloroaniline) , its cas register number is 101-14-4. It also can be called DACPM ; 4,4'-Diamino-3,3'-dichlorodiphenylmethane ; 2,2'-Dichloro-4,4'-methylene dianiline ; 4,4'-Methylenebis(2-chlorobenzenamine) ; Di(4-amino-3-chlorophenyl)methane ; 3,3'-Dichloro-4,4'-diaminodiphenyl methane ; 4,4'-Methylenebis(2-chloroaniline) .It is a off-white powder with slight odor.It insoluble in water and is a weak base.
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