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Cas Database |
| Name |
4-Amino-6-chlorobenzene-1,3-disulfonamide |
EINECS | 204-463-1 |
| CAS No. | 121-30-2 | Density | 1.768 g/cm3 |
| PSA | 163.10000 | LogP | 3.36040 |
| Solubility | N/A | Melting Point |
254.5 ºC |
| Formula | C6H8ClN3O4S2 | Boiling Point | 614.4 ºC at 760 mmHg |
| Molecular Weight | 285.732 | Flash Point | 325.4 ºC |
| Transport Information | N/A | Appearance | white to almost white crystalline powder |
| Safety | 28-36/37 | Risk Codes | 23/24-33 |
| Molecular Structure |
|
Hazard Symbols |
 T
|
| Synonyms |
m-Benzenedisulfonamide,4-amino-6-chloro- (8CI);1-Amino-5-chloro-2,4-benzenedisulfonamide;3-Chloro-4,6-disulfamoylaniline;4-Amino-6-chloro-1,3-benzenedisulfonamide;4-Amino-6-chloro-m-benzenedisulfonamide;5-Chloro-2,4-disulfamoylaniline;Chloraminophenamide;Chloroaminophenamide;Idorese;NSC 93772;Salamid;Salamide;Salamide (diuretic);Salmid;Su 5683; |
Article Data | 57 |
4-Amino-6-chlorobenzene-1,3-disulfonamide Synthetic route
| Conditions | Yield |
|---|---|
| With ammonia |
- 1824-58-4, 126048-38-2, 126048-39-3
d-ethiazide
A
- 121-30-2
chloraminophenamide
- 1824-58-4, 126048-38-2, 126048-39-3
l-ethiazide
| Conditions | Yield |
|---|---|
| With water at 37℃; phosphate buffer (pH: 7.4); or with human serum albumin; | |
| With water at 37℃; Rate constant; phosphate buffer (pH: 7.4); or with human serum albumin; |
- 1824-58-4, 126048-38-2, 126048-39-3
l-ethiazide
A
- 121-30-2
chloraminophenamide
- 1824-58-4, 126048-38-2, 126048-39-3
d-ethiazide
| Conditions | Yield |
|---|---|
| With water at 37℃; phosphate buffer (pH: 7.4); or with human serum albumin; | |
| With water at 37℃; Rate constant; phosphate buffer (pH: 7.4); or with human serum albumin; |
- 67-56-1
methanol
- 58-93-5
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
A
- 121-30-2
chloraminophenamide
B
- 40642-90-8
4-amino-1,3-benzenedisulfonamide
E
- 23141-82-4
3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
F
- 32059-40-8
6-methoxy-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
| Conditions | Yield |
|---|---|
| In water Product distribution; Mechanism; Irradiation; multistep reaction, photholytic decomposition; also in pure MeOH; effect of O2; |
- 58-93-5
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
- 121-30-2
chloraminophenamide
| Conditions | Yield |
|---|---|
| In methanol for 2160h; Product distribution; Ambient temperature; stability study; further temperature, further solvent; | |
| With sodium hydroxide at 95℃; for 1h; | |
| With sodium hydroxide at 80℃; for 3.5h; | |
| With hydrogenchloride In methanol; propan-1-ol; water for 80h; Kinetics; |
- 58-93-5
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
A
- 121-30-2
chloraminophenamide
B
- 50-00-0
formaldehyd
| Conditions | Yield |
|---|---|
| In ethanol at 90℃; for 528h; Equilibrium constant; Kinetics; Thermodynamic data; other temperature and time; |
| Conditions | Yield |
|---|---|
| pyrographite hydrolysis of benzothiadiazines; | |
| pyrographite hydrolysis; | |
| With water In ethanol at 35℃; Kinetics; Temperature; Solvent; pH-value; Concentration; |
- 58-93-5
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
A
- 121-30-2
chloraminophenamide
| Conditions | Yield |
|---|---|
| In water at 60℃; for 336000h; pH=5.2; Substitution; |
- 1824-58-4, 126048-38-2, 126048-39-3
d-ethiazide
- 121-30-2
chloraminophenamide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: water / 37 °C / phosphate buffer (pH: 7.4); or with human serum albumin 2: water / 37 °C / phosphate buffer (pH: 7.4); or with human serum albumin View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: ClSO3H 2: NH3 View Scheme | |
| Multi-step reaction with 2 steps 1: ClSO3H, NaCl / 150 °C 2: NH3 View Scheme |
4-Amino-6-chlorobenzene-1,3-disulfonamide Chemical Properties
The Molecular Structure of 1,3-Benzenedisulfonamide,4-amino-6-chloro- (CAS NO.121-30-2):
Empirical Formula: C6H8ClN3O4S2
Molecular Weight: 285.7284
IUPAC Name: 4-Amino-6-chlorobenzene-1,3-disulfonamide
Product Categories: Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
Nominal Mass: 285 Da
Average Mass: 285.7284 Da
Monoisotopic Mass: 284.964473 Da
Index of Refraction: 1.666
Molar Refractivity: 60.07 cm3
Molar Volume: 161.5 cm3
Surface Tension: 81.6 dyne/cm
Density: 1.768 g/cm3
Flash Point: 325.4 °C
Enthalpy of Vaporization: 91.17 kJ/mol
Boiling Point: 614.4 °C at 760 mmHg
Vapour Pressure: 4.98E-15 mmHg at 25 °C
Melting Point: 254.5 °C
log P (octanol-water): -0.41
Atmospheric OH Rate Constant: 3.46E-12 cm3/molecule-sec at 25 °C
InChI: InChI=1/C6H8ClN3O4S2/c7-3-1-4(8)6(16(10,13)14)2-5(3)15(9,11)12/h1-2H,8H2,(H2,9,11,12)(H2,10,13,14)
Smiles: O=S(=O)(N)c1c(N)cc(c(S(=O)(=O)N)c1)Cl
4-Amino-6-chlorobenzene-1,3-disulfonamide Uses
1,3-Benzenedisulfonamide,4-amino-6-chloro- (CAS NO.121-30-2) is used as pharmaceutical intermediates,and also can be used for synthesis of hydrochlorothiazide and other bulk drugs.
4-Amino-6-chlorobenzene-1,3-disulfonamide Safety Profile
Hazard Codes: 
T
Risk Statements: 23/24-33
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed
R33: Danger of cumulative effects
Safety Statements: 28-36/37
S28: After contact with skin, wash immediately with plenty of soap-suds
S36/37: Wear suitable protective clothing and gloves
WGK Germany: 3
4-Amino-6-chlorobenzene-1,3-disulfonamide Specification
1,3-Benzenedisulfonamide,4-amino-6-chloro- (CAS NO.121-30-2) is also called as 4-Amino-6-chloro-1,3-benzenedisulfonamide ; Chloraminophenamide ; 3-Chloro-4,6-disulfamoylaniline ; 4-Amino-6-chloro-m-benzenedisulfonamide ; 5-Chloro-2,4-disulfamoylaniline ; Chloraminophenamide ; Chloroaminophenamide ; 4-Amino-6-chlorobenzene-1,3-disulphonamide ; m-Benzenedisulfonamide, 4-amino-6-chloro- (8CI) .
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