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Cas Database |
| Name |
4-Chloro-4'-hydroxybenzophenone |
EINECS | 255-627-4 |
| CAS No. | 42019-78-3 | Density | 1.307 g/cm3 |
| PSA | 37.30000 | LogP | 3.27660 |
| Solubility | N/A | Melting Point |
177-181 °C |
| Formula | C13H9ClO2 | Boiling Point | 404 ºC at 760 mmHg |
| Molecular Weight | 232.666 | Flash Point | 198.1ºC |
| Transport Information | N/A | Appearance | light grey to beige-brown powder |
| Safety | 24/25-37/39-26-36 | Risk Codes | 36/37/38-20/21/22 |
| Molecular Structure |
|
Hazard Symbols |
 Xi, Xn
|
| Synonyms |
Benzophenone,4-chloro-4'-hydroxy- (6CI);(4-Chlorophenyl)(4-hydroxyphenyl)methanone;1-(4-Chlorophenyl)-1-(4-hydroxyphenyl)methanone;4-(4-Chlorobenzoyl)phenol; |
Article Data | 41 |
4-Chloro-4'-hydroxybenzophenone Synthetic route
- 42019-78-3
4-chloro-4'-hydroxybenzophenone
| Conditions | Yield |
|---|---|
| With tetrabutyl ammonium fluoride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Schlenk technique; | 97% |
- 2069-48-9
4-chloro-4'-fluoro-benzophenone
- 42019-78-3
4-chloro-4'-hydroxybenzophenone
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water; dimethyl sulfoxide at 120℃; for 16h; Inert atmosphere; Schlenk technique; | 94% |
| With potassium hydroxide In water; dimethyl sulfoxide at 60℃; for 18h; |
- 10547-60-1
4-chloro-4'-methoxybenzophenone
- 42019-78-3
4-chloro-4'-hydroxybenzophenone
| Conditions | Yield |
|---|---|
| With hydrogen bromide; acetic acid In water at 125℃; Reagent/catalyst; | 94% |
| With boron tribromide In tetrahydrofuran at -78 - 20℃; for 2h; | 92% |
| With aluminum (III) chloride In toluene at 0 - 100℃; for 4h; | 90% |
| Conditions | Yield |
|---|---|
| With dipotassium peroxodisulfate; trifluoroacetic acid In water; acetonitrile at 25℃; for 6h; Irradiation; | 90% |
| Conditions | Yield |
|---|---|
| With hydrogenchloride; zinc(II) chloride In water; 1,2-dichloro-ethane at 90℃; for 7h; Reflux; | 88.1% |
| Stage #1: 4-Cyanochlorobenzene; phenol With hydrogenchloride; zinc(II) chloride In 1,2-dichloro-ethane at 90℃; Stage #2: With hydrogenchloride; water In 1,2-dichloro-ethane at 20℃; for 5h; Temperature; Reflux; | 88.2% |
| Conditions | Yield |
|---|---|
| With oxygen; copper(l) chloride In acetonitrile at 25 - 28℃; for 20h; Irradiation; regioselective reaction; | 86% |
- 164852-89-5
4-((4-chlorophenyl)(hydroxy)methyl)phenol
- 42019-78-3
4-chloro-4'-hydroxybenzophenone
| Conditions | Yield |
|---|---|
| With oxygen; Langlois reagent In acetonitrile at 25℃; under 760.051 Torr; for 12h; Irradiation; | 76% |
- 1871-38-1
phenyl 4-chlorobenzoate
- 42019-78-3
4-chloro-4'-hydroxybenzophenone
| Conditions | Yield |
|---|---|
| With aluminium trichloride for 0.0833333h; | 41.3% |
| With aluminium trichloride |
- 1871-38-1
phenyl 4-chlorobenzoate
A
- 42019-78-3
4-chloro-4'-hydroxybenzophenone
B
- 2985-79-7
4'-chloro-2-hydroxybenzophenone
| Conditions | Yield |
|---|---|
| With aluminium trichloride |
- 4913-77-3
4-amino-4'-chlorobenzophenone
- 42019-78-3
4-chloro-4'-hydroxybenzophenone
| Conditions | Yield |
|---|---|
| With ethanol; sulfuric acid; sodium nitrite | |
| Multi-step reaction with 2 steps 1: sodium nitrite; alcoholic sulfuric acid / Diazotization.und nachfolgenden Kochen 2: glacial acetic acid; hydrobromic acid View Scheme |
4-Chloro-4'-hydroxybenzophenone Chemical Properties
The Molecular Structure of 4-Chloro-4'-hydroxybenzophenone (CAS NO.42019-78-3):
Empirical Formula: C13H9ClO2
Molecular Weight: 232.6624
IUPAC Name: (4-chlorophenyl)-(4-hydroxyphenyl)methanone
Appearance: light grey to beige-brown powder
Nominal Mass: 232 Da
Average Mass: 232.6624 Da
Monoisotopic Mass: 232.029107 Da
Index of Refraction: 1.623
Molar Refractivity: 62.82 cm3
Molar Volume: 177.9 cm3
Surface Tension: 51.9 dyne/cm
Density: 1.307 g/cm3
Flash Point: 198.1 °C
Enthalpy of Vaporization: 68.09 kJ/mol
Boiling Point: 404 °C at 760 mmHg
Vapour Pressure: 4.17E-07 mmHg at 25°C
Synonyms: 4-p-Chlorobenzoylphenol ; EINECS 255-627-4 ; 4-Chloro-4'-hydroxybenzophenone ; Methanone, (4-chlorophenyl)(4-hydroxyphenyl)-
Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Benzophenones & Derivatives (substituted)
4-Chloro-4'-hydroxybenzophenone Safety Profile
Hazard Codes: 
Xn
Xi
Risk Statements: 36/37/38-20/21/22
R36/37/38: Irritating to eyes, respiratory system and skin
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed
Safety Statements: 24/25-37/39-26-36
S24/25: Avoid contact with skin and eyes
S37/39: Wear suitable gloves and eye/face protection
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36: Wear suitable protective clothing
Hazard Note: Irritant
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