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Name	4-Chloro-6-ethyl-5-fluoropyrimidine	EINECS	604-010-1
CAS No.	137234-74-3	Density	1.286 g/cm³
PSA	25.78000	LogP	1.83150
Solubility	N/A	Melting Point	N/A
Formula	C₆H₆ClFN₂	Boiling Point	210.913 °C at 760 mmHg
Molecular Weight	160.578	Flash Point	81.358 °C
Transport Information	N/A	Appearance	N/A
Safety	22-36/37/39-45	Risk Codes	20/21/22-36/37/38
Molecular Structure		Hazard Symbols	20/21/22-36/37/38:;
Synonyms	Pyrimidine,4-chloro-6-ethyl-5-fluoro-;	Article Data	13

4-Chloro-6-ethyl-5-fluoropyrimidine Synthetic route

: 137234-87-8
6-ethyl-5-fluoropyrimidin-4(1H)-one

: 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine

Conditions

Conditions	Yield
With triethylamine; trichlorophosphate In dichloromethane at 48℃; for 6h; Product distribution / selectivity; Industry scale; Heating / reflux;	99%
With triethylamine; trichlorophosphate In dichloromethane for 5h; Product distribution / selectivity; Heating / reflux;	90%
With triethylamine; trichlorophosphate In dichloromethane at 40℃; for 5.16667h; Reflux;

: 137234-87-8
6-ethyl-5-fluoro-4-hydroxypyrimidine

: 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine

Conditions

Conditions	Yield
Stage #1: 6-ethyl-5-fluoro-4-hydroxypyrimidine With triethylamine; trichlorophosphate In dichloromethane for 5.5h; Heating / reflux; Stage #2: With hydrogenchloride; water In dichloromethane at 20℃;	95%
With triethylamine; trichlorophosphate In dichloromethane at 40℃; for 8h; Reflux;	90%
With trichlorophosphate In N,N-dimethyl-formamide at 90℃; for 5h;	90.2%

: 188416-35-5
3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

A: 86404-63-9
1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

B: 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine

Conditions

Conditions	Yield
With hydrogenchloride In water at 60 - 70℃; Temperature; Reagent/catalyst; Solvent;	A 88.4% B n/a

: 137234-87-8
6-Ethyl-5-fluoropyrimidin-4(3H)-one

: 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine

Conditions

Conditions	Yield
With trichlorophosphate Heating;

: 759-67-1
2-fluoro-3-oxopentanoic acid ethyl ester

: 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) MeONa, MeOH 2: POCl3 / Heating View Scheme
Multi-step reaction with 2 steps 1: sodium methylate / methanol / 20 h / 15 °C 2: trichlorophosphate / 3 h / 60 °C View Scheme

: 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine

: 188416-28-6
1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane

Conditions

Conditions	Yield
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In dichloromethane at 55℃; for 16h; Temperature;	98%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In dichloromethane for 12h; Reflux;	95.1%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In dichloromethane for 12h; Reflux;	95.1%

: 106-54-7
p-Chlorothiophenol

: 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine

: 1112937-23-1
4-(4-chloro-phenylsulfanyl)-6-ethyl-5-fluoropyrimidine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 10 - 20℃; for 2h;	96%

: 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine

: 4892-02-8
Methyl thiosalicylate

: 1258386-27-4
methyl 2-(6-ethyl-5-fluoropyrimidin-4-yl-sulfanyl)benzoate

Conditions

Conditions	Yield
Stage #1: Methyl thiosalicylate With sodium hydride In tetrahydrofuran at 5℃; for 0.666667h; Stage #2: 4-chloro-6-ethyl-5-fluoropyrimidine In tetrahydrofuran at 20 - 25℃;	96%

: 108-98-5
thiophenol

: 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine

: 1112937-27-5
4-(phenylsulfanyl)-6-ethyl-5-fluoropyrimidine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 10℃; for 2h;	95%

: (3-(3-phenylpropyl)piperidin-3-yl)methanol

: 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine

: (1-(6-ethyl-5-fluoropyrimidin-4-yl)-3-(3-phenylpropyl)piperidin-3-yl)methanol

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 120℃; for 17.3h; Sealed tube;	81%

4-Chloro-6-ethyl-5-fluoropyrimidine Chemical Properties

Structure of 4-Chloro-6-ethyl-5-fluoropyrimidine (CAS NO.137234-74-3):

Empirical Formula: C₆H₆ClFN₂
Molecular Weight: 160.5766
Index of Refraction: 1.502
Molar Refractivity: 36.873 cm³
Molar Volume: 124.859 cm³
Polarizability: 14.618×10^-24cm³
Surface Tension: 40.592 dyne/cm
Density: 1.286 g/cm³
Flash Point: 81.358 °C
Enthalpy of Vaporization: 42.896 kJ/mol
Boiling Point: 210.913 °C at 760 mmHg
Vapour Pressure: 0.272 mmHg at 25°C
Product Categories: APIs & Intermediate;Pyrimidine
Synonyms of 4-Chloro-6-ethyl-5-fluoropyrimidine (CAS NO.137234-74-3): Pyrimidine,4-chloro-6-ethyl-5-fluoro-

4-Chloro-6-ethyl-5-fluoropyrimidine Safety Profile

Risk Statements: 20/21/22-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-36/37/39-45
S22:Do not breathe dust.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

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