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Cas Database |
| Name |
4-Chloroanisole |
EINECS | 210-772-2 |
| CAS No. | 623-12-1 | Density | 1.137 g/cm3 |
| PSA | 9.23000 | LogP | 2.34860 |
| Solubility | Immiscible with water | Melting Point |
-18 °C |
| Formula | C7H7ClO | Boiling Point | 184.4 °C at 760 mmHg |
| Molecular Weight | 142.585 | Flash Point | 72.3 °C |
| Transport Information | UN 2810 | Appearance | colourless liquid |
| Safety | 23-24/25 | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
Anisole,p-chloro- (6CI,7CI,8CI);1-Chloro-4-methoxybenzene;1-Methoxy-4-chlorobenzene;4-Chlorophenol methyl ether;4-Methoxychlorobenzene;4-Methoxyphenyl chloride;Anisyl chloride;NSC 4129;p-Chloroanisole;p-Chloromethoxybenzene;p-Chlorophenyl methyl ether;p-Methoxychlorobenzene;p-Methoxyphenyl chloride; |
Article Data | 266 |
4-Chloroanisole Synthetic route
- 50619-99-3
4,4'-dimethoxy-diphenyliodonium chloride
- 623-12-1
4-chloromethoxybenzene
| Conditions | Yield |
|---|---|
| In benzene-d6 at 120℃; for 120h; Sealed tube; | 100% |
| Conditions | Yield |
|---|---|
| With nickel dichloride In N,N-dimethyl-formamide at 170℃; for 0.0833333h; microwave irradiation; | 99% |
| With trans-bis(glycinato)copper(II) monohydrate; tetramethlyammonium chloride In ethanol at 100℃; for 12h; Finkelstein Reaction; Schlenk technique; Inert atmosphere; | 91% |
| With copper(I) oxide; tetramethlyammonium chloride; L-proline In ethanol at 110℃; for 18h; Inert atmosphere; | 80% |
| Conditions | Yield |
|---|---|
| With 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; for 16h; Product distribution; Further Variations:; Temperatures; Solvents; Pressures; reaction times; microwave irradiation; | 99% |
| With N,N'-dimethylimidazolium-2-carboxylate In acetonitrile at 160℃; for 2h; Microwave irradiation; Green chemistry; | 94% |
| With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide for 0.0416667h; microwave irradiation; | 92% |
- 623-12-1
4-chloromethoxybenzene
| Conditions | Yield |
|---|---|
| With trichloroisocyanuric acid In water; ethyl acetate at 20℃; for 0.666667h; Open flask; | 98% |
| Conditions | Yield |
|---|---|
| With sodium chlorite; silica gel; manganese(III) acetylacetonate; sodium bromide In dichloromethane at 25℃; for 2h; | A 97% B 3% |
| With tetraethylammonium chloride; tetraethylammonium bromide Product distribution; 1.) CH2Cl2, RT, 1 h, electrolysis, 2.) CH2Cl2, RT, 24 h; other halogenating agents; other benzene derivatives and olefins; |
| Conditions | Yield |
|---|---|
| With methanol; Methyl formate; copper(l) chloride at 115℃; for 2h; Autoclave; Green chemistry; | 97% |
| Conditions | Yield |
|---|---|
| With potassium hydroxide; tetrabutylammomium bromide; potassium carbonate for 0.00694444h; Irradiation; microwave; | 89% |
| With sodium hydroxide at 100℃; | |
| With alkaline solution | |
| With potassium carbonate In acetone | |
| With lithium hydroxide In tetrahydrofuran for 1h; Ambient temperature; Yield given; |
| Conditions | Yield |
|---|---|
| With methanol; gold; hydrogen; caesium carbonate at 100℃; under 3800.26 Torr; for 71h; | 89% |
- 1330681-27-0
(4-methoxyphenyl)(mesityl)iodonium trifluoromethanesulfonate
- 623-12-1
4-chloromethoxybenzene
| Conditions | Yield |
|---|---|
| With copper(l) chloride In acetonitrile at 80℃; for 2h; | 87% |
- 14596-60-2
N-chloro-N-(4-methylphenyl)acetamide
- 100-66-3
methoxybenzene
A
- 623-12-1
4-chloromethoxybenzene
B
- 766-51-8
2-Chloroanisole
C
- 18931-78-7
N-(2-chloro-4-methylphenyl)acetamide
D
- 103-89-9
4-Methylacetanilide
| Conditions | Yield |
|---|---|
| at 110℃; for 12h; Mechanism; Orton Haloaniline Rearrangement; Inert atmosphere; Darkness; | A 82% B n/a C n/a D 87% |
4-Chloroanisole Chemical Properties
IUPAC Name:1-chloro-4-methoxybenzene
Molecular Formula:C7H7ClO
Molecular Weight:142.582880 g/mol
Appearance:yellow to colorless Clear liquid
Melting Point:-18 °C
Boiling Point:198-202 °C
Flash Point:173 °F
Solubility:ethanol and ether
Insolubility:water
Density:1.164 g/mL at 25 °C
Refractive index:n20/D 1.535
BRN:1858901
EINECS:210-772-2
Synonyms of 4-Chloroanisole (CAS NO.623-12-1): 1-chloro-4-methoxy-benzen ; 4-Chlorophenol methyl ether ; Anisole, p-chloro- ; Benzene,1-chloro-4-methoxy- ; para-Chloroanisole
Categories: Aromatic Ethers ; Anisoles, Alkyloxy Compounds & Phenylacetates ; Chlorine Compounds ; Ethers ; Organic Building Blocks ; Oxygen Compounds
4-Chloroanisole Uses
4-Chloroanisole (CAS NO.623-12-1) is used as an intermediate for fruit acid.
4-Chloroanisole Safety Profile
Safety Information of 4-Chloroanisole (CAS NO.623-12-1):
Hazard Codes:Xn 
Safety Statements:23-24/25
23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
24/25:Avoid contact with skin and eyes
RIDADR:UN 2810
WGK Germany:3
HS Code:29093090
4-Chloroanisole Specification
First Aid Measures of 4-Chloroanisole (CAS NO.623-12-1):
Eyes:Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.
Skin:Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:Remove from exposure and move to fresh air immediately.
Storage of 4-Chloroanisole (CAS NO.623-12-1):
Store in a cool, dry place. Keep container closed when not in use.
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