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Cas Database |
| Name |
4-Epoxypropanoxycarbazole |
EINECS | 610-764-2 |
| CAS No. | 51997-51-4 | Density | 1.327 g/cm3 |
| PSA | 37.55000 | LogP | 3.09870 |
| Solubility | N/A | Melting Point |
130-132 °C |
| Formula | C15H13NO2 | Boiling Point | 464.9 °C at 760 mmHg |
| Molecular Weight | 239.274 | Flash Point | 166.4 °C |
| Transport Information | N/A | Appearance | pale yellow to almost white powder |
| Safety | 36/37 | Risk Codes | 43-68 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
9H-Carbazole,4-(oxiranylmethoxy)- (9CI);4-(2,3-Epoxypropoxy)carbazole;4-Oxiranylmethoxy-9H-carbazole; |
Article Data | 26 |
4-Epoxypropanoxycarbazole Synthetic route
| Conditions | Yield |
|---|---|
| Stage #1: 9H-carbazol-4-ol With sodium hydroxide In water; isopropyl alcohol at 23 - 28℃; for 1h; Stage #2: epichlorohydrin In water; isopropyl alcohol at 20 - 40℃; for 15 - 20h; | 80.4% |
| Stage #1: 9H-carbazol-4-ol With sodium hydroxide In water Stage #2: epichlorohydrin In water; dimethyl sulfoxide at 10 - 45℃; for 7h; | 80.5% |
| Stage #1: 9H-carbazol-4-ol With sodium hydroxide In water; dimethyl sulfoxide at 10 - 30℃; for 0.25 - 0.333333h; Stage #2: epichlorohydrin at 10 - 30℃; for 25.5 - 30.75h; | 76.57% |
- 52602-39-8
9H-carbazol-4-ol
- 106-89-8
epichlorohydrin
A
- 1187921-93-2
1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol
B
- 51997-51-4
4-(2,3-epoxypropoxy)carbazole
| Conditions | Yield |
|---|---|
| With pyridine In isopropyl alcohol at 50 - 60℃; for 12h; Inert atmosphere; | A 80% B 10% |
| With potassium carbonate In isopropyl alcohol at 50 - 60℃; for 12h; Inert atmosphere; | A 20% B 60% |
- 106-89-8
epichlorohydrin
- 51997-51-4
4-(2,3-epoxypropoxy)carbazole
| Conditions | Yield |
|---|---|
| Stage #1: 9H-carbazol-4-ol With sodium dithionite; potassium carbonate; potassium iodide In acetone for 1h; Heating / reflux; Stage #2: epichlorohydrin In acetone at 20℃; for 32h; Heating / reflux; | 69.9% |
| Conditions | Yield |
|---|---|
| With sodium hydroxide In dimethyl sulfoxide at 60℃; for 24h; | 60% |
| With sodium hydroxide In water; dimethyl sulfoxide at 45℃; for 16h; | 31% |
| Stage #1: 9H-carbazol-4-ol With sodium hydride In N,N-dimethyl-formamide Stage #2: 1,2-Epoxy-3-bromopropane In N,N-dimethyl-formamide | |
| With potassium carbonate In butanone at 80℃; |
| Conditions | Yield |
|---|---|
| With potassium carbonate In butanone |
- 52602-39-8
9H-carbazol-4-ol
- 50-59-9
cefaloridine
- 67-68-5
dimethyl sulfoxide
- 51997-51-4
4-(2,3-epoxypropoxy)carbazole
| Conditions | Yield |
|---|---|
| With sodium hydroxide In dichloromethane; water; ethyl acetate |
- 67800-62-8
(S)-oxirane-2-methyl methanesulfonate
- 52602-39-8
9H-carbazol-4-ol
- 50-59-9
cefaloridine
- 51997-51-4
4-(2,3-epoxypropoxy)carbazole
| Conditions | Yield |
|---|---|
| With sodium hydroxide In dichloromethane; water; dimethyl sulfoxide; ethyl acetate |
- 3246-03-5
N-[2-(2'-(methoxy)-phenoxy)-ethyl]-benzylamine
- 51997-51-4
4-(2,3-epoxypropoxy)carbazole
- 72955-94-3
1-[benzyl[2(2-methoxyphenoxy)ethyl]amino]-3-(9H-carbazol-4-yloxy)propan-2-ol
| Conditions | Yield |
|---|---|
| With potassium carbonate In water at 20 - 90℃; for 3h; | 99% |
| Stage #1: N-[2-(2'-(methoxy)-phenoxy)-ethyl]-benzylamine; 4-(2,3-epoxypropoxy)carbazole With zinc(II) chloride In ethyl acetate at 70 - 75℃; for 3h; Stage #2: With ammonia In water | |
| With trifluoroacetic acid In 1,4-dioxane at 70 - 75℃; for 48h; |
- 100-46-9
benzylamine
- 51997-51-4
4-(2,3-epoxypropoxy)carbazole
- 934370-86-2
1-(9H-carbazol-4-yloxy)-3-phenylmethylamino-2-propanol
| Conditions | Yield |
|---|---|
| In water at 60℃; for 10h; Product distribution / selectivity; | 98.7% |
| at 40℃; for 1h; Temperature; | 97.79% |
| In toluene Heating; | 72% |
| In toluene Reflux; | 72% |
- 51997-51-4
4-(2,3-epoxypropoxy)carbazole
- 74-88-4
methyl iodide
- 890017-26-2
9-methyl-4-(oxiran-2-ylmethoxy)-9H-carbazole
| Conditions | Yield |
|---|---|
| With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 4h; | 97% |
| With sodium hydride In N,N-dimethyl-formamide at 20℃; for 4h; | 92% |
| With sodium hydroxide In N,N-dimethyl-formamide at 60℃; for 2h; | 81% |
| With sodium hydroxide In N,N-dimethyl-formamide at 60℃; for 2h; | 81% |
4-Epoxypropanoxycarbazole Chemical Properties
IUPAC Name: 4-(Oxiran-2-ylmethoxy)-9H-carbazole
Synonyms of 4-Epoxypropanoxycarbazole (CAS NO.51997-51-4): 4-(2,3-Epoxypropoxy)-carbazole
CAS NO: 51997-51-4
Molecular Formula: C15H13NO2
Molecular Weight: 239.27
Molecular Structure: 
H bond acceptors: 3
H bond donors: 1
Freely Rotating Bonds: 3
Polar Surface Area: 26.69 Å2
Index of Refraction: 1.729
Molar Refractivity: 71.89 cm3
Molar Volume: 180.2 cm3
Surface Tension: 63.1 dyne/cm
Density: 1.327 g/cm3
Flash Point: 166.4 °C
Enthalpy of Vaporization: 69.86 kJ/mol
Boiling Point: 464.9 °C at 760 mmHg
Vapour Pressure: 2.23E-08 mmHg at 25°C
Melting Point: 130-132°C
Appearance: pale yellow to almost white powder
SMILES: O(c3c1c(nc2ccccc12)ccc3)CC4OC4
InChI: InChI=1/C15H13NO2/c1-2-5-12-11(4-1)15-13(16-12)6-3-7-14(15)18-9-10-8-17-10/h1-7,10,16H,8-9H2 Copy
InChIKey: SVWKIGRDISDRLO-UHFFFAOYAD
Std. InChI: InChI=1S/C15H13NO2/c1-2-5-12-11(4-1)15-13(16-12)6-3-7-14(15)18-9-10-8-17-10/h1-7,10,16H,8-9H2 Std. InChIKey: SVWKIGRDISDRLO-UHFFFAOYSA-N
Product Categories of 4-Epoxypropanoxycarbazole (CAS NO.51997-51-4): Chemical intermediate for Benidipin;PHARMACEUTICAL INTERMEDIATES;(intermediate of carvedilol);Aromatics Compounds;Carbazoles;Oxiranes;Simple 3-Membered Ring Compounds;Carvedilol Intermediate;Aromatics
4-Epoxypropanoxycarbazole Uses
4-Epoxypropanoxycarbazole (CAS NO.51997-51-4) is used for the intermediate in the synthesis of carvedilol and Carazolol which are anti-hypertensive drug.
4-Epoxypropanoxycarbazole Safety Profile
Hazard Codes: 
Xi
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