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4-Hydroxyphenethyl alcohol
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Name

4-Hydroxyphenethyl alcohol

 EINECS 207-930-8
CAS No. 501-94-0 Density 1.168 g/cm3
PSA 40.46000 LogP 0.92700
Solubility slightly soluble in water Melting Point 89-92 °C(lit.)
Formula C8H10O2 Boiling Point 287.8 °C at 760 mmHg
Molecular Weight 138.166 Flash Point 143.2 °C
Transport Information N/A Appearance off-white to light beige crystals or crystalline
Safety 26-37/39-24/25-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 501-94-0 (4-Hydroxyphenethyl alcohol) Hazard Symbols IrritantXi
Synonyms

Phenethylalcohol, p-hydroxy- (7CI,8CI);Tyrosol (6CI);2-(4-Hydroxyphenyl)ethanol;2-(4-Hydroxyphenyl)ethyl alcohol;2-(p-Hydroxyphenyl)ethanol;4-(2-Hydroxyethyl)phenol;Benzeneethanol,4-hydroxy-;NSC 59876;Tyrosol C;p-(2-Hydroxyethyl)phenol;p-HPEA;p-Hydroxyphenethylalcohol;p-Tyrosol;b-(4-Hydroxyphenyl)ethanol;b-(p-Hydroxyphenyl)ethanol;4-Hydroxyphenylethanol;

Article Data 94

4-Hydroxyphenethyl alcohol Synthetic route

156-38-7

4-hydroxyphenylacetate

501-94-0

p-hydroxyphenethyl alcohol

Conditions
ConditionsYield
With sodium tetrahydroborate; Trimethyl borate; dimethyl sulfate In tetrahydrofuran at 20℃; for 1.5h;98%
With sodium tetrahydroborate; iodine In tetrahydrofuran for 2h; Heating;88%
With lithium aluminium tetrahydride In tetrahydrofuran at 67℃; for 2.5h;88%
7400-08-0

p-Coumaric Acid

A

156-38-7

4-hydroxyphenylacetate

B

501-94-0

p-hydroxyphenethyl alcohol

Conditions
ConditionsYield
With β-D-glucose; oxygen for 18h; Reagent/catalyst; Enzymatic reaction;A n/a
B 97.3%

1-methylsulfanylmethoxy-4-(2-methylsulfanylmethoxy-ethyl)-benzene

501-94-0

p-hydroxyphenethyl alcohol

Conditions
ConditionsYield
With methanol; iodine at 50℃; for 3.5h;96%

1-(2-methoxy-ethoxymethoxy)-4-[2-(2-methoxy-ethoxymethoxy)-ethyl]-benzene

501-94-0

p-hydroxyphenethyl alcohol

Conditions
ConditionsYield
With methanol; iodine at 50℃; for 48h;96%
96013-68-2

tert-butyl(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenoxy)dimethylsilane

501-94-0

p-hydroxyphenethyl alcohol

Conditions
ConditionsYield
With methanol; trimethylsilyl bromide at 20℃; for 5h; chemoselective reaction;95%
With antimonypentachloride; water In acetonitrile at 20℃; for 0.166667h;92%
With iron(III) p-toluenesulfonate hexahydrate In methanol for 26.25h; Reflux;84%

1-(2-trimethylsilanyl-ethoxymethoxy)-4-[2-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-benzene

501-94-0

p-hydroxyphenethyl alcohol

Conditions
ConditionsYield
With methanol; iodine at 50℃; for 10h;95%

1-methoxymethoxy-4-(2-methoxymethoxy-ethyl)-benzene

501-94-0

p-hydroxyphenethyl alcohol

Conditions
ConditionsYield
With methanol; iodine at 50℃; for 34h;94%
14199-15-6

Methyl 4-hydroxyphenylacetate

501-94-0

p-hydroxyphenethyl alcohol

Conditions
ConditionsYield
With methanol; Na/SiO2 In tetrahydrofuran at 0 - 25℃; Bouveault-Blanc reduction; Inert atmosphere;93%
With 5 wt% Re/TiO2; hydrogen In octane at 200℃; under 37503.8 Torr; for 24h; Autoclave; chemoselective reaction;91%
With sodium tetrahydroborate In water for 8h; Ambient temperature;90%
14140-15-9

4-(2-bromoethyl)phenol

501-94-0

p-hydroxyphenethyl alcohol

Conditions
ConditionsYield
Stage #1: 4-(2-bromoethyl)phenol With sodium acetate In water for 3h; Reflux;
Stage #2: With sodium hydroxide In water for 0.5h; Inert atmosphere; Reflux;		88%

2-[4-(4-nitro-benzyloxy)-phenyl]-ethanol

A

501-94-0

p-hydroxyphenethyl alcohol

B

106-49-0

p-toluidine

Conditions
ConditionsYield
With magnesium In methanol at 20℃; for 10h;A 83%
B n/a

4-Hydroxyphenethyl alcohol Chemical Properties

Molecule structure of 4-Hydroxyphenethyl alcohol (CAS NO.501-94-0):

IUPAC Name: 4-(2-Hydroxyethyl)phenol 
Molecular Weight: 138.1638 g/mol
Molecular Formula: C8H10O2 
Density: 1.168 g/cm3 
Melting Point: 89-92 °C(lit.)
Boiling Point: 287.8 °C at 760 mmHg 
Flash Point: 143.2 °C
Index of Refraction: 1.577
Molar Refractivity: 39.21 cm3
Molar Volume: 118.1 cm3
Surface Tension: 50.8 dyne/cm
Enthalpy of Vaporization: 55.66 kJ/mol
Vapour Pressure: 0.00113 mmHg at 25 °C 
Water Solubility: slightly soluble
XLogP3: 0.4
H-Bond Donor: 2
H-Bond Acceptor: 2
Rotatable Bond Count: 2
Tautomer Count: 2
Exact Mass: 138.06808
MonoIsotopic Mass: 138.06808
Topological Polar Surface Area: 40.5
Heavy Atom Count: 10
Canonical SMILES: C1=CC(=CC=C1CCO)O
InChI: InChI=1S/C8H10O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,9-10H,5-6H2
InChIKey: YCCILVSKPBXVIP-UHFFFAOYSA-N
EINECS: 207-930-8
Product Categories: Alcohols and Derivatives; Benzhydrols, Benzyl & Special Alcohols; Benzene derivates; Alkohols; API intermediates

4-Hydroxyphenethyl alcohol Uses

 4-Hydroxyphenethyl alcohol (CAS NO.501-94-0) is used as pharmaceutical intermediates.

4-Hydroxyphenethyl alcohol Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39-24/25-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S37/39:Wear suitable gloves and eye/face protection. 
S24/25:Avoid contact with skin and eyes. 
S36:Wear suitable protective clothing.
WGK Germany: 3
F: 10
Hazard Note: Irritant
HS Code: 29072900

4-Hydroxyphenethyl alcohol Specification

 4-Hydroxyphenethyl alcohol (CAS NO.501-94-0) is also named as 2-(4-Hydroxyphenyl)ethanol ; NSC 59876 ; p-Hydroxyphenethyl alcohol ; 4-Hydroxyphenethyl alcohol ; Benzeneethanol, 4-hydroxy- . 4-Hydroxyphenethyl alcohol (CAS NO.501-94-0) is off-white to light beige crystals or crystalline.

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