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Name |
4-Nitro-2,3-lutidine-N-oxide |
EINECS | -0 |
CAS No. | 37699-43-7 | Density | 1.3 g/cm3 |
PSA | 71.28000 | LogP | 2.16330 |
Solubility | N/A | Melting Point |
94-98 °C(lit.) |
Formula | C7H8N2O3 | Boiling Point | 403.3 °C at 760 mmHg |
Molecular Weight | 168.152 | Flash Point | 197.7 °C |
Transport Information | UN 2811 | Appearance | N/A |
Safety | 26-36 | Risk Codes | 36/37/38-20/21/22 |
Molecular Structure | Hazard Symbols | Xn, Xi | |
Synonyms |
2,3-Lutidine,4-nitro-, 1-oxide (7CI);2,3-Dimethyl-4-nitropyridine 1-oxide;2,3-Dimethyl-4-nitropyridine N-oxide;4-Nitro-2,3-dimethylpyridine N-oxide; |
Article Data | 18 |
2,3-dimethylpyridine 1-oxide
2,3-dimethyl-4-nitropyridine N-oxide
Conditions | Yield |
---|---|
With potassium nitrite; sulfuric acid at -10 - 85℃; for 2h; Temperature; Green chemistry; | 92.9% |
With sulfuric acid; nitric acid at 100℃; for 5h; | 78% |
With sulfuric acid; nitric acid at 95℃; for 20h; | 53% |
2-methyl-4-nitropyridine N-oxide
2,3-dimethyl-4-nitropyridine N-oxide
Conditions | Yield |
---|---|
Stage #1: 2-methyl-4-nitropyridine N-oxide; methylmagnesium halide In tetrahydrofuran at -60℃; Inert atmosphere; Stage #2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran at -60 - 20℃; Inert atmosphere; regioselective reaction; | 47% |
2,3-dimethylpyridine 1-oxide
A
3-methoxy-2-methyl-6-nitropyridine 1-oxide
B
2,3-dimethyl-4-nitropyridine N-oxide
Conditions | Yield |
---|---|
With nitric acid In acetic acid at 80℃; for 33h; |
2,3-dimethylpyridine 1-oxide
dichloromethane
B
2,3-dimethyl-4-nitropyridine N-oxide
Conditions | Yield |
---|---|
With sodium hydroxide; sulfuric acid; nitric acid In water |
2,3-dimethylpyridine 1-oxide
sodium carbonate
A
4-carboxy-2-nitropyridine N-oxide
B
2,3-dimethyl-4-nitropyridine N-oxide
Conditions | Yield |
---|---|
With nitric acid |
2,3-Lutidine
2,3-dimethyl-4-nitropyridine N-oxide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dihydrogen peroxide; acetic acid / 24 h / Reflux 2: nitric acid; sulfuric acid / 24 h / 90 °C View Scheme | |
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / chloroform / 18 h / 20 °C 2: nitric acid; sulfuric acid / 95 °C View Scheme | |
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C 2: sulfuric acid; nitric acid / water / 5 h / 95 °C View Scheme |
2,3-dimethyl-4-nitropyridine N-oxide
4-chloro-2,3-dimethylpyridine-N-oxide
Conditions | Yield |
---|---|
With acetyl chloride In ethanol at 65℃; for 5h; | 100% |
With hydrogenchloride; sodium chloride; benzyltri(n-butyl)ammonium chloride In water; acetonitrile for 12h; Heating / reflux; | 98.5% |
Stage #1: 2,3-dimethyl-4-nitropyridine N-oxide With hydrogenchloride; benzyltri(n-butyl)ammonium chloride; sodium chloride In water; acetonitrile for 12h; Heating / reflux; Stage #2: In water; acetonitrile pH=9; | 98.5% |
2,3-dimethyl-4-nitropyridine N-oxide
Cyclopropylmethanol
4-Cyclopropylmethoxy-2,3-dimethyl-pyridine 1-oxide
Conditions | Yield |
---|---|
With benzyltri(n-butyl)ammonium chloride; potassium hydrogencarbonate In acetonitrile for 24h; Heating; | 100% |
methanol
2,3-dimethyl-4-nitropyridine N-oxide
4-methoxy-2,3-dimethylpyridine 1-oxide
Conditions | Yield |
---|---|
With potassium carbonate for 2h; Heating; | 99% |
With potassium carbonate at 0 - 65℃; for 4h; | 83% |
With potassium carbonate for 20h; Heating; | 82% |
With potassium carbonate In acetonitrile at 0℃; Reflux; | 47% |
With sodium methylate at 40℃; for 16h; |
2,3-dimethyl-4-nitropyridine N-oxide
acetyl chloride
4-chloro-2,3-dimethylpyridine-N-oxide
Conditions | Yield |
---|---|
Stage #1: 2,3-dimethyl-4-nitropyridine N-oxide; acetyl chloride In ethanol at 65℃; Large scale reaction; Stage #2: With sodium hydroxide In ethanol; water; toluene pH=7.5 - 8.5; Large scale reaction; | 96% |
Molecular structure of 4-Nitro-2,3-lutidine-N-oxide (CAS NO.37699-43-7) is:
Product Name: 4-Nitro-2,3-lutidine-N-oxide
CAS Registry Number: 37699-43-7
IUPAC Name: 2,3-dimethyl-4-nitro-1-oxidopyridin-1-ium
Molecular Weight: 168.15002 [g/mol]
Molecular Formula: C7H8N2O3
XLogP3-AA: 0.5
H-Bond Donor: 0
H-Bond Acceptor: 3
Melting Point: 94-98 °C(lit.)
Surface Tension: 49.2 dyne/cm
Density: 1.3 g/cm3
Flash Point: 197.7 °C
Enthalpy of Vaporization: 62.9 kJ/mol
Boiling Point: 403.3 °C at 760 mmHg
Vapour Pressure: 2.4E-06 mmHg at 25°C
Product Categories: Pyridines;Pyridines derivates;C7 and C8;Heterocyclic Building Blocks
4-Nitro-2,3-lutidine-N-oxide (CAS NO.37699-43-7) is used as an intermediate of drug lansoprazole.
1. | mmo-sat 100 nmol/plate | GANNA2 Gann. Japanese Journal of Cancer Research. 70 (1979),799. | ||
2. | dnr-esc 500 µg/well | CNREA8 Cancer Research. 32 (1972),2369. |
Safty information about 4-Nitro-2,3-lutidine-N-oxide (CAS NO.37699-43-7) is:
Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RIDADR: 2811
WGK Germany: 3
RTECS: UT2807000
HazardClass: 6.1
PackingGroup: III
4-Nitro-2,3-lutidine-N-oxide , its cas register number is 37699-43-7. It also can be called 2,3-Dimethyl-4-nitropyridine 1-oxide ; Pyridine, 2,3-dimethyl-4-nitro-, 1-oxide .