Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	5-Benzyloxyindole-3-carboxaldehyde	EINECS	230-134-7
CAS No.	6953-22-6	Density	1.267 g/cm³
PSA	42.09000	LogP	3.55940
Solubility	N/A	Melting Point	237-238 °C
Formula	C₁₆H₁₃NO₂	Boiling Point	474.2 °C at 760 mmHg
Molecular Weight	251.285	Flash Point	240.6 °C
Transport Information	N/A	Appearance	white to light yellow crystal powder
Safety	22-24/25-36/37-26	Risk Codes	36-43
Molecular Structure		Hazard Symbols	Xi
Synonyms	Indole-3-carboxaldehyde,5-(benzyloxy)- (7CI);5-Benzyloxy-1H-indole-3-carboxaldehyde;5-Benzyloxy-3-formylindole;5-Benzyloxy-3-indolecarboxaldehyde;NSC 71049;	Article Data	18

5-Benzyloxyindole-3-carboxaldehyde Synthetic route

: 288-32-4
1H-imidazole

: 1215-59-4
5-benzyloxy-1H-indole

: 6953-22-6
5-benzyloxyindole-3-carboxaldehyde

Conditions

Conditions	Yield
Stage #1: 1H-imidazole; 5-benzyloxy-1H-indole With acetic anhydride at 130℃; for 1h; Stage #2: With sodium hydroxide In ethanol; water for 1h; Heating; Further stages.;	91%

: 1215-59-4
5-benzyloxy-1H-indole

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 6953-22-6
5-benzyloxyindole-3-carboxaldehyde

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 0℃; for 0.25h; Stage #2: 5-benzyloxy-1H-indole at 50 - 60℃; for 1.5h; Stage #3: With sodium hydroxide In water at 0℃; for 0.0333333h; Heating / reflux;	84%
Stage #1: 5-benzyloxy-1H-indole; N,N-dimethyl-formamide With trichlorophosphate at 20℃; for 0.5h; Stage #2: With sodium hydroxide In water at 0℃;	83%
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at -30 - 20℃; for 0.5h; Vilsmeier-Haack Formylation; Stage #2: 5-benzyloxy-1H-indole at 20℃; for 1h; Vilsmeier-Haack Formylation;	81%

: 5-benzyloxy-1-tosyl-1H-indole-3-carboxaldehyde

: 6953-22-6
5-benzyloxyindole-3-carboxaldehyde

Conditions

Conditions	Yield
With triethylamine; 2-amino-3-(5-hydroxy-1H-indol-3-yl)propionic acid methyl ester In methanol for 6h; Microwave irradiation; Reflux;	55%

: 1215-59-4
5-benzyloxy-1H-indole

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 10025-87-3, 12599-09-6, 63736-95-8
trichlorophosphate

: 6953-22-6
5-benzyloxyindole-3-carboxaldehyde

Conditions

Conditions	Yield
und Erwaermen des Reaktionsprodukts mit wss.Natronlauge oder mit wss.Natriumcarbonat-Loesung.;

: 2581-34-2
3-methyl-4-nitrophenol

2-nitro-m-cresol; 6-nitro-m-cresol: 2-nitro-m-cresol; 6-nitro-m-cresol

: 6953-22-6
5-benzyloxyindole-3-carboxaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium carbonate / acetone / 5 h / Heating 2: 2.) hydrazine hydrate / 2.) Raney nickel / 1.) reflux, 3 h, 2.) THF, MeOH, RT, 30 min 3: 1.) phosphorus oxychloride, 2.) conc. HCl / 1.) 0 deg C, 1 h, 2.) MeOH, THF, RT, 45 min View Scheme

: 22424-58-4
5-benzyloxy-2-nitrotoluene

: 6953-22-6
5-benzyloxyindole-3-carboxaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2.) hydrazine hydrate / 2.) Raney nickel / 1.) reflux, 3 h, 2.) THF, MeOH, RT, 30 min 2: 1.) phosphorus oxychloride, 2.) conc. HCl / 1.) 0 deg C, 1 h, 2.) MeOH, THF, RT, 45 min View Scheme

: 100-39-0
benzyl bromide

CO: CO

: 6953-22-6
5-benzyloxyindole-3-carboxaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium carbonate / acetone / 5 h / Heating 2: 2.) hydrazine hydrate / 2.) Raney nickel / 1.) reflux, 3 h, 2.) THF, MeOH, RT, 30 min 3: 1.) phosphorus oxychloride, 2.) conc. HCl / 1.) 0 deg C, 1 h, 2.) MeOH, THF, RT, 45 min View Scheme

: 6640-09-1
5-benzyloxy-1H-indole-2-carboxylic acid

: 6953-22-6
5-benzyloxyindole-3-carboxaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: copper oxide-chromium oxide; quinoline / 280 °C 2: phosphoryl chloride / und anschliessenden Hydrolysieren mit wss.Natronlauge bzw. wss.Natriumcarbonat-Loesung View Scheme

: 1215-59-4
5-benzyloxy-1H-indole

: 6953-22-6
5-benzyloxyindole-3-carboxaldehyde

: 79-37-8
oxalyl dichloride

: 1215-59-4
5-benzyloxy-1H-indole

: 6953-22-6
5-benzyloxyindole-3-carboxaldehyde

Conditions

Conditions	Yield
With N,N-dimethyl-formamide at 20℃; for 5h;

5-Benzyloxyindole-3-carboxaldehyde Chemical Properties

Molecular Structure of 5-Benzyloxyindole-3-carboxaldehyde(6953-22-6):

IUPAC Name:5-phenylmethoxy-1H-indole-3-carbaldehyde
Molecular Formula:C₁₆H₁₃NO₂
Molecular Weight:251.279920 g/mol
Appearance:white to light yellow crystal powder
Melting Point:237-238 °C
Density:1.267 g/cm³
Flash Point:240.6 °C
Enthalpy of Vaporization:73.74 kJ/mol
Boiling Point:474.2 °C at 760 mmHg
Vapour Pressure:3.7E-09 mmHg at 25°C
Water Solubility:21.18 mg/L at 25 °C
Sensitive:Air
EINECS:230-134-7
Synonyms of 5-Benzyloxyindole-3-carboxaldehyde(6953-22-6):
5-BENZYLOXYINDOLE-3-ALDEHYDE;5-BENZYLOXYINDOLE-3-CARBALDEHYDE;5-BENZYLOXYINDOLE-3-CARBOXALDEHYDE;5-BENZYLOXY INDOLE-3-CARBOXYALDEHYDE;5-BENZYLOXYINDOLE-3-FORMALDEHYDE;5-(BENZYLOXY)-3-INDOLECARBOXYALDEHYDE;5-BENZYLOXY-3-FORMYLINDOLE;5-(BENZYLOXY)-1H-INDOLE-3-CARBALDEHYDE
Categories of 5-Benzyloxyindole-3-carboxaldehyde(6953-22-6):
blocks;Carboxes;IndolesOxindoles;Indoles and derivatives;Indoline & Oxindole;Indoles;Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;Heterocyclic Building Blocks

5-Benzyloxyindole-3-carboxaldehyde Uses

5-Benzyloxyindole-3-carboxaldehyde(6953-22-6) is used as a pharmaceutical intermediate.

5-Benzyloxyindole-3-carboxaldehyde Safety Profile

Safety Information of 5-Benzyloxyindole-3-carboxaldehyde(6953-22-6):
Hazard Codes:Xi

Risk Statements:36-43
36:Irritating to the eyes
43:May cause sensitization by skin contac
Safety Statements:22-24/25-36/37-26
22:Do not breathe dust
24/25:Avoid contact with skin and eyes
36/37:Wear suitable protective clothing and gloves
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany:3

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 6953-22-6