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5-Bromo-2-picoline

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Name

5-Bromo-2-picoline

EINECS -0
CAS No. 3430-13-5 Density 1.494 g/cm3
PSA 12.89000 LogP 2.15250
Solubility N/A Melting Point 32-36 °C
Formula C6H6BrN Boiling Point 182.7 °C at 760 mmHg
Molecular Weight 172.024 Flash Point 64.3 °C
Transport Information N/A Appearance Light yellow cryst.
Safety 26-36-36/37/39 Risk Codes 36/37/38-20/21/22
Molecular Structure Molecular Structure of 3430-13-5 (5-Bromo-2-methylpyridine) Hazard Symbols HarmfulXn, IrritantXi
Synonyms

5-Bromo-2-methylpyridine;2-Methyl-5-bromopyridine;Pyridine, 5-bromo-2-methyl-;5-bormo-2-methylpyridine;

Article Data 16

5-Bromo-2-picoline Synthetic route

80287-53-2, 3430-14-6

5-Amino-2-methylpyridine

3430-13-5

5-bromo-2-methylpyridine

Conditions
ConditionsYield
Stage #1: 5-Amino-2-methylpyridine With hydrogen bromide; bromine at -20 - -15℃; for 1.66667h;
Stage #2: With sodium nitrite In water at 20℃; for 1h;
Stage #3: With sodium hydroxide In water at -15 - 20℃; for 1h;
99%
Stage #1: 5-Amino-2-methylpyridine With hydrogen bromide; bromine In water at -20 - -15℃; for 1.66667h;
Stage #2: With sodium hydroxide; sodium nitrite In water at -25 - 20℃; for 1h; Time;
99%
With potassium nitrite; sulfuric acid anschliessend Behandeln mit Kupfer(I)-bromid;

5-bromo-2-pyridylacetic acid hydrochloride

3430-13-5

5-bromo-2-methylpyridine

Conditions
ConditionsYield
at 180℃; under 33 Torr;61%
109-06-8

α-picoline

3430-13-5

5-bromo-2-methylpyridine

Conditions
ConditionsYield
With aluminium trichloride; bromine at 100℃; for 2.5h;11%
With aluminum (III) chloride; bromine
14401-91-3

picoline hydrochloride

3430-13-5

5-bromo-2-methylpyridine

Conditions
ConditionsYield
With bromine Erhitzen des Reaktionsprodukts auf 130grad;
109-06-8

α-picoline

A

3430-13-5

5-bromo-2-methylpyridine

B

38749-79-0

3-bromo-2-picoline

Conditions
ConditionsYield
With aluminium trichloride; bromine at 100℃; for 0.5h;A 14.4 g
B 9.5 g
With aluminium trichloride; bromine at 100℃; for 19h;A n/a
B 4.2 g
6960-22-1

6-methylnicotinamide

3430-13-5

5-bromo-2-methylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOCl; aqueous KOH
2: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid
View Scheme
21684-59-3

ethyl 6-methylnicotinate

3430-13-5

5-bromo-2-methylpyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aqueous NH3
2: NaOCl; aqueous KOH
3: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid
View Scheme
Multi-step reaction with 5 steps
1: N2H4+H2O
2: KNO2; aqueous HCl
4: aqueous KOH
5: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid
View Scheme
197079-25-7

6-methylpyridine-3-carbohydrazide

3430-13-5

5-bromo-2-methylpyridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: KNO2; aqueous HCl
3: aqueous KOH
4: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid
View Scheme
64038-04-6

6-methyl-nicotinoyl azide

3430-13-5

5-bromo-2-methylpyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
2: aqueous KOH
3: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid
View Scheme
247077-42-5

(6-methyl-[3]pyridyl)-carbamic acid ethyl ester

3430-13-5

5-bromo-2-methylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous KOH
2: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid
View Scheme

5-Bromo-2-picoline Chemical Properties

Molecular Formula: C6H6BrN
Molar mass: 172.0225 g/mol
Density: 1.494 g/cm3
Flash Point: 64.3 °C
Index of Refraction: 1.553
Melting point: 32-36 °C
Appearance: Light yellow Cryst
Boiling Point: 182.7 °C at 760 mmHg
Vapour Pressure: 1.09 mmHg at 25°C
Structure of 5-Bromo-2-picoline (3430-13-5) :
                         
Product Categories: blocks;Pyridines derivates;Bromides;Bromopyridines;Pyridine series;Halopyridines;Pyridines, Pyrimidines, Purines and Pteredines

5-Bromo-2-picoline Toxicity Data With Reference

Carcinogenicity of 5-Bromo-2-picoline (3430-13-5) hasn't been listed as a carcinogen by NTP, IARC,ACGIH, or CA Prop 65. And its toxicological properties have not been fully investigated.

5-Bromo-2-picoline Safety Profile

Hazard Note: Irritant
Hazard Codes: Xn,Xi
Risk Statements:
20:  Harmful by inhalation
21:  Harmful in contact with skin
22:  Harmful if swallowed 
36:  Irritating to the eyes
37:  Irritating to the respiratory system
38:  Irritating to the skin
Safety Statements:
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing 
37:  Wear suitable gloves
39:  Wear eye/face protection

5-Bromo-2-picoline Specification

 5-Bromo-2-picoline (3430-13-5) is a compound which can be called for 5-Bromo-2-methylpyridine ; 2-Methyl-5-bromopyridine .It's can be used for pharmaceutical intermediates. 5-Bromo-2-picoline (3430-13-5) is hazardous,so the first aid measures and others should be known .Such as: When on the skin: first,should  flush skin with plenty of water immediatelyfor at least 15 minutes while removing contaminated clothing .Secondly,Get shoesmedical aid . Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.Then get medical aid soon.While ,it's Inhaled: Remove from exposure and move to fresh air immediately.Give artificial respiration While not breathing. when breathing is difficult, give oxygen.And as soon as to get medical aid .Then you have the ingesting of the product : Wash mouth out with water,and get medical aid immediately.
In addition, 5-Bromo-2-picoline (3430-13-5) can be stable under normal temperature and pressure conditions.It is not compatible with strong oxidizing agents and you must not take it with incompatible materials .And also prevent it to broken down into hazardous decomposition products: hydrogen bromide, oxides of nitrogen,carbon dioxide,carbon monoxide.

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