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5-Chloro-2-methylaniline

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5-Chloro-2-methylaniline

EINECS 202-452-6
CAS No. 95-79-4 Density 1.18 g/cm3
PSA 26.02000 LogP 2.81180
Solubility < 1 g/L (22 °C) in water Melting Point 22 °C
Formula C7H8ClN Boiling Point 237 °C at 760 mmHg
Molecular Weight 141.6 Flash Point 160 °C
Transport Information UN 3429 6.1/PG 3 Appearance clear yellow to light brown liquid after melting
Safety 26-45-36/37/39-53 Risk Codes 22-36/37/38-40-45-23/24/25
Molecular Structure Molecular Structure of 95-79-4 (95-79-4) Hazard Symbols HarmfulXn, ToxicT
Synonyms

Fast Red KBBase (6CI);o-Toluidine, 5-chloro- (8CI);2-Amino-4-chlorotoluene;2-Methyl-5-chloroaniline;3-Chloro-6-methylaniline;4-Chloro-2-aminotoluene;5-Chloro-2-methylaniline;5-Chloro-2-methylbenzenamine;5-Chloro-2-methylphenylamine;5-Chloro-2-toluidine;5-Chloro-o-toluidine;AccoFast Red KB base;Ansibase Red KB;Azoene Fast Red KB base;Fast Red KB amine;Fast Red KB salt;Fast Red KB salt Supra;Fast Red KB-T Base;Fast Red KBSsalt;Genazo Red KB soln;Hiltonil Fast Red KB base;Metrogen Red Former KBsoln;NSC 7094;Naphthosol Fast Red KB base;Pharmazoid Red KB;Red KB base;Spectrolene Red KB;Stable Red KB base;

Article Data 24

5-Chloro-2-methylaniline Chemical Properties

Molecular Formula:C7H8ClN
Molar mass:141.59812g/mol
Structure of 5-Chloro-2-methylaniline(95-79-4):
             
Synonyms of 5-Chloro-2-methylaniline(95-79-4):5-Chloro-o-toluidine;1-Amino-3-chloro-6-methylbenzene;4-chloro-2-aminotoluene[qr];2-amino-4-chlorotoluene[qr];2-Methyl-5-chloroaniline;3-chloro-6-methylaniline[qr]
Density:1.18 g/cm3 
Flash Point:160 °C                          
Boiling Point:237 °C at 760 mmHg      
Index of Refraction:1.585      
Vapour Pressure:0.0459 mmHg at 25°C
Melting point:22°C
Water solubility:< 1 g/L (22°C)
Solubility:soluble in ethanol, ether and other organic solvents alkaline solution.
Appearance:Solid off-white or light brown oily liquid

5-Chloro-2-methylaniline Uses

5-Chloro-2-methylaniline(95-79-4) can be a direct synthesis of azoic dyes red-based KB and Naphthol AS-KB in  dyestuff industry, and also is an important pesticide intermediates.

5-Chloro-2-methylaniline Toxicity Data With Reference

1.   

dni-mus-orl 200 mg/kg

   MUREAV    Mutation Research. 46 (1977),305.
2.   

orl-rat LD50:464 mg/kg

   NCILB*    Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD) NIH-NCI-E-C-72-3252 .
4.  dog LDLo oral > 100mg/kg (100mg/kg)  
"Pesticide Index," Frear, E.H., ed., State College, 5.PA, College Science Pub., 1969Vol. 4, Pg. 113, 1969. domestic animals - goat/sheep LDLo oral > 200mg/kg (200mg/kg)  
"Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969Vol. 4, Pg. 113, 1969.
6.  rat LD50 oral 464mg/kg (464mg/kg)  
Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973.
7.  Carcinogenicity:5-Chloro-2-methylaniline(95-79-4)- Not listed as a carcinogen by  NTP, IARC,ACGIH, or CA Prop 65. 
Other: See actual entry in RTECS for complete information.Mutagenicity: Ames-test: negative.The toxicological properties have not been fully investigated.

5-Chloro-2-methylaniline Consensus Reports

NTP Carcinogenesis Bioassay (feed): Clear Evidence: mouse NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-TR-187 ,1979. ; (feed): Inadequate Studies: rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-TR-187 ,1979. . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

5-Chloro-2-methylaniline Safety Profile

Suspected carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of Cl and NOx. See also AROMATIC AMINES.
Hazard Codes:Xn,T
Risk Statements:
22:  Harmful if swallowed
23:  Toxic by inhalation
24:  Toxic in contact with skin
25:  Toxic if swallowed
36:  Irritating to the eyes
37:  Irritating to the respiratory system
38:  Irritating to the skin
40:  Limited evidence of a carcinogenic effect
45:  May cause cancer
Safety Statements:
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing 
37:  Wear suitable gloves
39:  Wear eye/face protection
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
53:  Avoid exposure - obtain special instruction before use

5-Chloro-2-methylaniline Standards and Recommendations

DFG MAK: Confirmed Animal Carcinogen with Unknown Relevance to Humans
DOT Classification:  6.1; Label: KEEP AWAY FROM FOOD

5-Chloro-2-methylaniline Specification

Stability and Reactivity of 5-Chloro-2-methylaniline(95-79-4):
Conditions to Avoid:Incompatible materials,light.  
Incompatibilities with Other Materials:Strong oxidizing agents, chloroformates, acids, acid anhydrides, acid chlorides.
Hazardous Decomposition Products: Carbon dioxide, nitrogen oxides,hydrogen chloride, carbon monoxide.
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