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Cas Database |
| Name |
5-Ethyl-2-pyridineethanol |
EINECS | 226-024-3 |
| CAS No. | 5223-06-3 | Density | 1.037 g/cm3 |
| PSA | 33.12000 | LogP | 1.17880 |
| Solubility | N/A | Melting Point |
39-44℃ |
| Formula | C9H13 N O | Boiling Point | 259.4 °C at 760 mmHg |
| Molecular Weight | 151.208 | Flash Point | 110.7 °C |
| Transport Information | N/A | Appearance | White to Straw Yellow Crystals |
| Safety | 26-36/37/39-36 | Risk Codes | 21-36-36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
2-(5-Ethyl-2-pyridinyl)ethanol;2-(5-Ethyl-2-pyridyl)ethanol;2-(5-Ethylpyridin-2-yl)ethanol;5-Ethyl-2-(2-hydroxyethyl)pyridine;5-Ethyl-2-(b-hydroxyethyl)pyridine; |
Article Data | 10 |
5-Ethyl-2-pyridineethanol Synthetic route
- 104-90-5
5-ethyl-2-methyl-pyridine
- 50-00-0
formaldehyd
A
- 5408-74-2
5-ethyl-2-vinyl-pyridine
B
- 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine
| Conditions | Yield |
|---|---|
| With dipotassium peroxodisulfate; ethanol at 220℃; | |
| In water at 155℃; under 4500.45 Torr; for 4h; Pressure; Autoclave; | A n/a B 70 g |
| Conditions | Yield |
|---|---|
| With sodium hydroxide at 160 - 170℃; | |
| With formic acid; water at 240℃; under 139011 Torr; | |
| With formic acid; 3-tert-butylbenzene-1,2-diol In ethanol for 120h; Heating; | |
| In water at 150 - 160℃; under 3750.38 - 4500.45 Torr; for 3h; Concentration; Time; Pressure; Temperature; Autoclave; |
| Conditions | Yield |
|---|---|
| With formaldehyd |
- 784149-51-5
3-(6-bromo-pyridin-3-yl)-2-methoxy-2-methyl-propionic acid methyl ester
- 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine
| Conditions | Yield |
|---|---|
| With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; caesium carbonate; palladium diacetate In toluene for 16h; Heating; | 100% |
- 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine
- 124-63-0
methanesulfonyl chloride
- 144809-26-7
2-(5-ethyl-pyridin-2-yl)ethyl methanesulfonate
| Conditions | Yield |
|---|---|
| With triethylamine In dichloromethane at 5 - 20℃; for 1.5h; | 99% |
| With triethylamine In toluene at 5 - 20℃; for 0.833333h; | 98% |
| With triethylamine In dichloromethane at 20℃; for 24h; | 89% |
- 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine
- 1122-91-4
4-bromo-benzaldehyde
- 114393-97-4
4-[2-(5-ethylpyridyl)ethoxy]benzaldehyde
| Conditions | Yield |
|---|---|
| With 4,4-bis(2-naphthyl)-1,3,5,7,8-pentamethyl-2,4-diethyl-4-bora-3a,4a-diaza-s-indacene; N,N-dicyclohexylmethylamine; nickel dibromide In N,N-dimethyl-formamide at 40℃; for 48h; Reagent/catalyst; Inert atmosphere; | 95% |
- 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine
- 350-46-9
4-Fluoronitrobenzene
- 85583-54-6
4-(2-(5-ethyl-2-pyridyl)ethoxy)nitrobenzene
| Conditions | Yield |
|---|---|
| With Aliquat 336; sodium hydroxide In 1,2-dichloro-ethane at 0 - 5℃; for 4h; Solvent; Reagent/catalyst; Temperature; | 94.4% |
| With sodium hydroxide In water at 20 - 35℃; for 16h; Product distribution / selectivity; | 88.4% |
| With sodium hydroxide In water; dimethyl sulfoxide at 20 - 35℃; for 12h; Product distribution / selectivity; | 88.11% |
- 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine
| Conditions | Yield |
|---|---|
| With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at -2 - 20℃; for 24.5h; Mitsunobu Displacement; | 81.3% |
- 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine
- 90643-32-6
2-(5-ethyl-1-oxypyridin-2-yl)ethanol
| Conditions | Yield |
|---|---|
| With dihydrogen peroxide; acetic acid In water at 100℃; for 14h; Product distribution / selectivity; | 81% |
| With dihydrogen peroxide In acetic acid at 100℃; for 14h; | 81% |
- 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine
| Conditions | Yield |
|---|---|
| With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at -2 - 20℃; for 24.5h; Mitsunobu Displacement; | 78.1% |
5-Ethyl-2-pyridineethanol Chemical Properties
5-Ethyl-2-pyridineethanol(5223-06-3) exists as white to straw yellow crystals.
Molecular Structure: 
Molecular Formula: C9H13NO.
Molecular Weight: 151.21.
Density: 1.037 g/cm3.
Boiling Point: 127 ℃(5 mmHg).
Flash Point: 110.7 ℃.
5-Ethyl-2-pyridineethanol Uses
5-Ethyl-2-pyridineethanol(5223-06-3) is used as building block in chemical synthesis. 5-Ethyl-2-pyridineethanol(5223-06-3) is used as raw material of Pioglitazone that can cure sugar diabetes type two.
5-Ethyl-2-pyridineethanol Safety Profile
Harmful in contact with skin. Risk of serious damage to eyes. Toxic in contact with skin.
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