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5-Fluoro-2-oxindole

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Name

5-Fluoro-2-oxindole

EINECS 446-540-4
CAS No. 56341-41-4 Density 1.311 g/cm3
PSA 29.10000 LogP 1.45830
Solubility N/A Melting Point 143-147 °C(lit.)
Formula C8H6FNO Boiling Point 307.197 °C at 760 mmHg
Molecular Weight 151.14 Flash Point 139.588 °C
Transport Information N/A Appearance Light Yellow Crystalline
Safety 22-24/25-45-36/37/322-24/25-45-36/37/39-27-269-27-26 Risk Codes 36/37/38-34
Molecular Structure Molecular Structure of 56341-41-4 (5-Fluoro-2-oxindole) Hazard Symbols IrritantXi, CorrosiveC
Synonyms

5-Fluoro-1,3-dihydro-2H-indol-2-one;5-Fluoro-1,3-dihydroindol-2-one;5-Fluoro-2,3-dihydro-2-oxoindole;5-Fluoro-2-oxoindoline;5-Fluoroindolin-2-one;5-Fluoro-1,3-dihydro-indol-2-one;

Article Data 75

5-Fluoro-2-oxindole Synthetic route

443-69-6

5-fluoro-1H-indole-2,3-dione

56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With hydrazine hydrate In water at 140℃; for 6h; Temperature; Wolff-Kishner-Huang Minlon Reduction;99.1%
With titanium tetrachloride; zinc In tetrahydrofuran at 20℃; for 0.1h; Inert atmosphere;87%
Stage #1: 5-fluoro-1H-indole-2,3-dione With potassium hydroxide; hydrazine In ethylene glycol at 80℃; for 3h;
Stage #2: With hydrogenchloride; water In ethylene glycol at 0 - 20℃; for 12h; pH=1 - 2;
81.9%
389571-36-2

5-fluoro-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester

56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With hydrogenchloride In methanol; water for 2h; Reagent/catalyst; Temperature; Inert atmosphere; Reflux;92.1%
Stage #1: 5-fluoro-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester With hydrogenchloride In methanol; water at 80℃; for 5h;
Stage #2: With potassium hydroxide In methanol; water at 40℃; for 0.5h;
79-04-9

chloroacetyl chloride

371-40-4

4-fluoroaniline

56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With montmorillonite KSF at 20℃; for 1.08333h; Stolle synthesis; Sonication; Neat (no solvent);88%
29640-99-1

methyl 2-(5-fluoro-2-nitrophenyl)acetate

56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With iron In acetic acid at 100℃; for 1h;87%
18108-55-9

1,3-dihydro-1-hydroxyindole-2-one

56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With diethylamino-sulfur trifluoride In dichloromethane at 0℃; for 0.0833333h;81%
283584-52-1

5-fluoro-3-hydrazonoindolin-2-one

56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 5h; Reflux;80.4%
With potassium tert-butylate In ethanol for 2h; Reflux; Inert atmosphere;
With sodium ethanolate
351-83-7

4'-fluoroacetanilide

623-48-3

ethyl iodoacetae

56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With silver(I) acetate; palladium diacetate; trifluoroacetic acid at 120℃; for 24h; Sealed tube; Inert atmosphere; Schlenk technique;78%
29640-98-0

(5-Fluoro-2-nitro-phenyl)-acetic Acid

56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With ammonium formate on silica gel; zinc In carbon dioxide at 50℃; under 90009 Torr; Autoclave; liquid CO2;76%

(E)-5-fluoro-3-hydrazonoindolin-2-one

56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 6h; Reflux;73.6%
356068-89-8

(2-amino-5-fluoro-phenyl)-acetic acid hydrazide

56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
In water73%
In water73%
With hydrogenchloride In water at 20℃; for 12h; pH=3;73%

5-Fluoro-2-oxindole Chemical Properties


IUPAC Name: 5-Fluoro-1,3-dihydroindol-2-one
Molecular Formula: C8H6FNO
Molecular Weight: 151.14 g/mol
Canonical SMILES: C1C2=C(C=CC(=C2)F)NC1=O
InChI: InChI=1S/C8H6FNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11)
Product Categories: INDOLE; blocks; FluoroCompounds; IndolesOxindoles; Indole/indoline/oxindole; Indole and Indoline; Heterocycles; Indoles and derivatives; Halides; Pyrroles & Indoles; ketone; Sunitinib; Aromatics Compounds; Intermediate of sunitinib malate; Aromatics; Pyrroles & Indoles; Boronic Acid;Heterocyclic Compounds; Building Blocks; Heterocyclic Building Blocks; Indoles; Fluorinated heterocyclic series
Index of Refraction: 1.56 
Molar Refractivity: 37.28 cm3 
Molar Volume: 115.2 cm3 
Polarizability:  14.78×10-24 cm
Surface Tension: 41.8 dyne/cm 
Density: 1.311 g/cm
Flash Point: 139.6 °C
Enthalpy of Vaporization:  54.78 kJ/mol 
Boiling Point: 307.2 °C at 760 mmHg 
Melting Point: 143-147 °C(lit.)
Storage temperature: Keep Cold
Vapour Pressure of 5-Fluorooxindole (CAS NO.56341-41-4): 0.000736 mmHg at 25 °C

5-Fluoro-2-oxindole Safety Profile

Safty informations of 5-Fluorooxindole (CAS NO.56341-41-4):
Hazard Codes:IrritantXiCorrosiveC
Risk Statements: 36/37/38-34 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R34:Causes burns.
Safety Statements: 22-24/25-45-36/37/39-27-26 
S22:Do not breathe dust. 
S24/25:Avoid contact with skin and eyes. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S27:Take off immediately all contaminated clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
Hazard Note: Irritant/Keep Cold 
HazardClass: IRRITANT, KEEP COLD 

5-Fluoro-2-oxindole Specification

  5-Fluorooxindole (CAS NO.56341-41-4), its Synonyms are 5-Fluoroindole-2-One ; 5-Fluoro-1,3-dihydro-indol-2-one ; 5-Fluorooxindole 98% . It is light yellow crystalline.

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