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Cas Database

Name	5-Methylpyridin-3-amine	EINECS	624-420-4
CAS No.	3430-19-1	Density	1.068 g/cm³
PSA	38.91000	LogP	1.55340
Solubility	N/A	Melting Point	59-63 °C
Formula	C₆H₈N₂	Boiling Point	261.1 °C at 760 mmHg
Molecular Weight	108.143	Flash Point	135.6 °C
Transport Information	N/A	Appearance	COLORLESS TO YELLOW SOLID
Safety	26-36/37/39	Risk Codes	22-37/38-41-20/21/22
Molecular Structure		Hazard Symbols	T, Xi, Xn
Synonyms	3-Picoline,5-amino- (7CI,8CI);(5-Methylpyridin-3-yl)amine;3-Amino-5-methylpyridine;5-Methyl-3-pyridinamine;	Article Data	11

5-Methylpyridin-3-amine Synthetic route

: 70-57-5
5-methylpyridinylcarboxamide

: 3430-19-1
5-methylpyridin-3-amine

Conditions

Conditions	Yield
With potassium hydroxide; bromine 1.) RT, 1 h, 2.) 70 deg C, 15 min;	67%
With sodium hydroxide; bromine In tetrahydrofuran at 5 - 70℃; Hoffmann rearrangement;

: 18344-51-9
2-amino-3-methyl-5-nitropyridine

: 3430-19-1
5-methylpyridin-3-amine

Conditions

Conditions	Yield
With hydrazine In water at 110 - 120℃; for 5h;	45%
Multi-step reaction with 3 steps 1: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser 2: phosphoryl chloride 3: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation View Scheme
Multi-step reaction with 2 steps 1: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser 2: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation View Scheme

: 7598-26-7
5-Methyl-3-nitro-2-aminopyridine

: 3430-19-1
5-methylpyridin-3-amine

Conditions

Conditions	Yield
With hydrazine In water at 110 - 120℃; for 5h;	41%

: 22280-56-4
2-chloro-3-methyl-5-nitropyridine

: 3430-19-1
5-methylpyridin-3-amine

Conditions

Conditions	Yield
With palladium on activated charcoal; sodium acetate; acetic acid Hydrogenation;

: 591-22-0
3,5-Lutidine

: 3430-19-1
5-methylpyridin-3-amine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 27 percent / potassium permanganate / H2O / 1.) from RT to 43 deg C, 5 h, 2.) 45 deg C, overnight 2: thionyl chloride / Heating 3: ammonia gas / 1,2-dichloro-ethane / 0.5 h / -30 °C 4: 67 percent / bromine, aq. potassium hydroxide / 1.) RT, 1 h, 2.) 70 deg C, 15 min View Scheme

: 3222-49-9
5-methylnicotinic acid

: 3430-19-1
5-methylpyridin-3-amine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: thionyl chloride / Heating 2: ammonia gas / 1,2-dichloro-ethane / 0.5 h / -30 °C 3: 67 percent / bromine, aq. potassium hydroxide / 1.) RT, 1 h, 2.) 70 deg C, 15 min View Scheme

: 884494-95-5
5-methyl-nicotinic acid chloride

: 3430-19-1
5-methylpyridin-3-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonia gas / 1,2-dichloro-ethane / 0.5 h / -30 °C 2: 67 percent / bromine, aq. potassium hydroxide / 1.) RT, 1 h, 2.) 70 deg C, 15 min View Scheme

: 1603-40-3
3-methylpyridin-2-ylamine

: 3430-19-1
5-methylpyridin-3-amine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: H2SO4; HNO3 2: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser 3: phosphoryl chloride 4: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation View Scheme
Multi-step reaction with 3 steps 1: H2SO4; HNO3 2: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser 3: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation View Scheme

: 21901-34-8
2-hydroxy-3-methyl-5-nitropyridine

: 3430-19-1
5-methylpyridin-3-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: phosphoryl chloride 2: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation View Scheme

: 23132-21-0
2-bromo-3-methyl-5-nitropyridine

: 3430-19-1
5-methylpyridin-3-amine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol

5-Methylpyridin-3-amine Chemical Properties

Molecule structure of 3-Amino-5-Methylpyridine (CAS NO.3430-19-1) :

IUPAC Name: (2S)-2-amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid
Molecular Weight: 215.6336 g/mol
Molecular Formula: C₉H₁₀ClNO₃
Density: 1.068 g/cm³
Melting Point: 59-63 °C
Boiling Point: 261.1 °C at 760 mmHg
Flash Point: 135.6 °C
Molar Volume: 101.2 cm³
Polarizability: 13.24*10^-24 cm³
Surface Tension: 46.9 dyne/cm
Enthalpy of Vaporization: 49.88 kJ/mol
Vapour Pressure: 0.0118 mmHg at 25 °C
XLogP3: -1.8
H-Bond Donor: 3
H-Bond Acceptor: 4
Rotatable Bond Count: 3
Tautomer Count: 3
Exact Mass: 215.034921
MonoIsotopic Mass: 215.034921
Topological Polar Surface Area: 83.6
Heavy Atom Count: 14
Complexity: 212
Defined Atom StereoCenter Count: 1
Canonical SMILES: C1=CC(=C(C=C1CC(C(=O)O)N)Cl)O
Isomeric SMILES: C1=CC(=C(C=C1C[C@@H](C(=O)O)N)Cl)O
InChI: InChI=1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
InChIKey: ACWBBAGYTKWBCD-ZETCQYMHSA-N
Product Categories of 3-Amino-5-Methylpyridine (CAS NO.3430-19-1) : VARIOUSAMINE; Heterocyclic Compounds; Amino; Intermediate; Pyridine; Boronic Acid; Heterocyclic Building Blocks; Pyridines; Building Blocks

5-Methylpyridin-3-amine Safety Profile

Hazard Codes: Toxic T, Irritant Xi, Harmful Xn
Risk Statements: 22-37/38-41-20/21/22
R22: Harmful if swallowed
R37/38: Irritating to respiratory system and skin
R41:Risk of serious damage to the eyes
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed
Safety Statements: 26-36/37/39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S36: Wear suitable protective clothing
Hazard Note: Toxic

5-Methylpyridin-3-amine Specification

3-Amino-5-Methylpyridine (CAS NO.3430-19-1) is also called 3-Amino-5-picoline ; 5-Methyl-pyridin-3-ylamine ; 3-Amino-5-methylpyridine97% ; 3-Pyridinamine,5-methyl-(9CI) ; 5-Methyl-3-pyridylamine hydrochloride salt ; 5-Methyl-3-pyridinamine ; 5-Amino-3-methylpyridine .

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5-Methylpyridin-3-amine

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