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7-Chloro-2-methylquinoline
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Name

7-Chloro-2-methylquinoline

 EINECS 440-600-3
CAS No. 4965-33-7 Density 1.225 g/cm3
PSA 12.89000 LogP 3.19660
Solubility N/A Melting Point 74-78 °C(lit.)
Formula C10H8ClN Boiling Point 278.177 °C at 760 mmHg
Molecular Weight 177.633 Flash Point 148.736 °C
Transport Information N/A Appearance white to light yellow crystal powder
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 4965-33-7 (7-Chloro-2-methylquinoline) Hazard Symbols HarmfulXn
Synonyms

7-Chloro-2-methylquinoline(7-Chloroquinaldine);Quinoline, 7-chloro-2-methyl-;7-chloro-2-methyl-quinoline;7-chlorquinaldine;7-Chloroquinaldine;

Article Data 33

7-Chloro-2-methylquinoline Synthetic route

123-42-2

4-Hydroxy-4-methyl-2-pentanone

59236-37-2

2-amino-4-chlorobenzaldehyde

4965-33-7

2-methyl-7-chloroquinoline

Conditions
ConditionsYield
With chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); sodium t-butanolate In toluene at 70℃; Inert atmosphere; Schlenk technique; chemoselective reaction;90%
123-73-9

trans-Crotonaldehyde

108-42-9

3-chloro-aniline

4965-33-7

2-methyl-7-chloroquinoline

Conditions
ConditionsYield
With phospho-tungstic acid; phosphotungstic acid; silica gel for 0.2h; Doebner-Miller reaction; microwave irradiation;86%
With hydrogenchloride; chloranil In tetrahydrofuran; methanol; iso-butanol

7-chloro-2-methyl-1,2,3,4-tetrahydroquinoline

4965-33-7

2-methyl-7-chloroquinoline

Conditions
ConditionsYield
With tetrasodium cobalt(II) 4,4',4'',4'''-tetrasulphophthalocyanine In water; ethyl acetate at 20℃; for 18h; Irradiation; Green chemistry;85%
With rose bengal; oxygen In N,N-dimethyl acetamide at 20℃; for 24h; Irradiation;73%
With rose bengal In N,N-dimethyl acetamide at 20℃; for 28h; Irradiation;73%
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; Co(dmgH)2(4-MeCO2Py)Cl In water at 28℃; for 12h; Schlenk technique; Inert atmosphere; Irradiation;73%
With 1,10-Phenanthroline; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium tert-butylate; oxygen; nickel dibromide In tert-Amyl alcohol at 95℃; for 48h;42%
109-92-2

ethyl vinyl ether

108-42-9

3-chloro-aniline

4965-33-7

2-methyl-7-chloroquinoline

Conditions
ConditionsYield
With magnetite-palladium-graphene nanocomposite In acetonitrile at 80℃; for 12h;72%
64-17-5

ethanol

108-42-9

3-chloro-aniline

A

4965-33-7

2-methyl-7-chloroquinoline

B

4964-69-6

2-methyl-5-chloroquinoline

Conditions
ConditionsYield
With iron(III) chloride hexahydrate In tetrachloromethane at 140℃; for 4h; Autoclave; Inert atmosphere; Sealed tube;A 11%
B 67%
108-42-9

3-chloro-aniline

123-73-9

crotonaldehyde

4965-33-7

2-methyl-7-chloroquinoline

Conditions
ConditionsYield
Stage #1: 3-chloro-aniline; crotonaldehyde With hydrogenchloride In water; toluene at 110℃; for 1.5h;
Stage #2: With zinc(II) chloride In tetrahydrofuran; water; acetone; toluene at 60℃; for 1h; Cooling with ice;		30%
With hydrogenchloride In water; toluene for 2h; Doebner-Miller Quinoline Synthesis; Reflux;
With hydrogenchloride; 1-methyl-2-nitrobenzene In water at 100℃; for 9h; Reagent/catalyst; Skraup Quinoline Synthesis; Reflux;
10138-89-3

1,1,3-trimethoxybutane

141-85-5

3-chloroaniline hydrochloride

4965-33-7

2-methyl-7-chloroquinoline

Conditions
ConditionsYield
With ethanol; iron(III) chloride; zinc(II) chloride
75-07-0

acetaldehyde

108-42-9

3-chloro-aniline

4965-33-7

2-methyl-7-chloroquinoline

Conditions
ConditionsYield
With hydrogenchloride
75-07-0

acetaldehyde

108-42-9

3-chloro-aniline

A

4965-33-7

2-methyl-7-chloroquinoline

B

4964-69-6

2-methyl-5-chloroquinoline

Conditions
ConditionsYield
With di-μ-chlorobis(norbornadiene)dirhodium(I); 3-Nitrochlorobenzene In ethanol at 180℃; for 4h; Yield given. Yields of byproduct given;
106237-28-9

β-(m-chloroanilino)crotonaldehyde

A

4965-33-7

2-methyl-7-chloroquinoline

B

4964-69-6

2-methyl-5-chloroquinoline

Conditions
ConditionsYield
With sulfuric acid at 25℃; Rate constant;

7-Chloro-2-methylquinoline Chemical Properties

Molecular Structure:

Molecular Formula: C10H8ClN
Molecular Weight: 177.6302
IUPAC Name: 7-Chloro-2-methylquinoline
Synonyms of 7-Chloroquinaldine (CAS NO.4965-33-7): Quinoline, 7-chloro-2-methyl-
CAS NO: 4965-33-7
Product Categories: Quinolines, Quinazolines and derivatives ; Halides ; Quinolines, Isoquinolines & Quinoxalines ; Quinoline&Isoquinoline ; API ; Alkylquinolines ; Haloquinolines ; Quinolines ; Quinolines, Isoquinolines & Quinoxalines
Melting point: 74-78 °C 
Polar Surface Area: 12.89 Å2
Index of Refraction: 1.634
Molar Refractivity: 51.9 cm3
Molar Volume: 144.9 cm3
Surface Tension: 46.5 dyne/cm
Density: 1.225 g/cm3
Flash Point: 148.7 °C
Enthalpy of Vaporization: 49.6 kJ/mol
Boiling Point: 278.2 °C at 760 mmHg
Vapour Pressure: 0.00732 mmHg at 25°C

 

7-Chloro-2-methylquinoline Uses

 7-Chloroquinaldine (CAS NO.4965-33-7) is used as a  Pharmaceutical intermediates.

7-Chloro-2-methylquinoline Safety Profile

Safety Information of 7-Chloroquinaldine (CAS NO.4965-33-7):
Hazard Codes: Xi
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin  
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing 
WGK Germany: 3

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