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Acetic acid,2-(2-chloroethoxy)-

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Name

Acetic acid,2-(2-chloroethoxy)-

EINECS 604-645-4
CAS No. 14869-41-1 Density 1.296 g/cm3
PSA 46.53000 LogP 0.32640
Solubility N/A Melting Point 32.5-33.0 °C
Formula C4H7ClO3 Boiling Point 289.753 °C at 760 mmHg
Molecular Weight 138.551 Flash Point 129.038 °C
Transport Information N/A Appearance Brown crystal
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 14869-41-1 (2-CHLOROETHOXY ACETIC ACID) Hazard Symbols N/A
Synonyms

Aceticacid, (2-chloroethoxy)- (8CI,9CI);1-Chloro-2-(carboxymethoxy)ethane;2-Chloroethoxyacetic acid;2-CHLOROETHOXY ACETIC ACID;

Article Data 16

Acetic acid,2-(2-chloroethoxy)- Synthetic route

123-91-1

1,4-dioxane

14869-41-1

(2-chloroethoxy)-acetic acid

Conditions
ConditionsYield
With dipotassium peroxodisulfate; thionyl chloride at 25℃; for 4h;96.1%
With hydrogenchloride; sodium hypochlorite

tert-butyl 2-(2-chloroethoxy)acetate

14869-41-1

(2-chloroethoxy)-acetic acid

Conditions
ConditionsYield
With hydrogenchloride; water for 2h;95%
17229-14-0

(2-chloro-ethoxy)-acetic acid ethyl ester

14869-41-1

(2-chloroethoxy)-acetic acid

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran90%
628-89-7

2-(2-Chloroethoxy)ethanol

14869-41-1

(2-chloroethoxy)-acetic acid

Conditions
ConditionsYield
With chromium(VI) oxide; sulfuric acid In acetone at 0℃; for 6h;77%
With sodium periodate; ruthenium trichloride In water; acetonitrile at 20℃; for 16h;74%
Stage #1: 2-(2-Chloroethoxy)ethanol With calcium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate In dichloromethane; water at 20℃; for 0.5h;
Stage #2: With sodium metabisulfite In dichloromethane; water
72%
31250-08-5

2-chloroethyl cyanomethyl ether

14869-41-1

(2-chloroethoxy)-acetic acid

Conditions
ConditionsYield
With hydrogenchloride
124-38-9

carbon dioxide

821-50-1

(2-chloroethoxy)magnesium chloride

14869-41-1

(2-chloroethoxy)-acetic acid

Conditions
ConditionsYield
In tetrahydrofuran at -60℃;
28547-59-3

1-chloro-2-(2-nitro-ethoxy)-ethane

14869-41-1

(2-chloroethoxy)-acetic acid

Conditions
ConditionsYield
With hydrogenchloride
111-46-6

diethylene glycol

14869-41-1

(2-chloroethoxy)-acetic acid

Conditions
ConditionsYield
With hydrogenchloride; sodium hypochlorite
14869-41-1

(2-chloroethoxy)-acetic acid

1075705-01-9

4-fluoro-2-methoxy-5-nitro-phenylamine

2-(2-chloroethoxy)-N-(4-fluoro-2-methoxy-5-nitrophenyl)acetamide

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide99%
313682-08-5

brecanavir

14869-41-1

(2-chloroethoxy)-acetic acid

(1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl (2-chloroethoxy)acetate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 24h;92%

Acetic acid,2-(2-chloroethoxy)- Specification

The Acetic acid,2-(2-chloroethoxy)-, with the CAS registry number 14869-41-1, is also known as 2-(2-Chloroethoxy)acetic acid. This chemical's molecular formula is C4H7ClO3 and molecular weight is 138.5496. Its systematic name is called (2-chloroethoxy)acetic acid.

Physical properties of Acetic acid,2-(2-chloroethoxy)-: (1)ACD/LogP: -0.18; (2)ACD/LogD (pH 5.5): -2; (3)ACD/LogD (pH 7.4): -4; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 4; (11)Index of Refraction: 1.45; (12)Molar Refractivity: 28.739 cm3; (13)Molar Volume: 106.935 cm3; (14)Surface Tension: 41.367 dyne/cm; (15)Density: 1.296 g/cm3; (16)Flash Point: 129.038 °C; (17)Enthalpy of Vaporization: 58.21 kJ/mol; (18)Boiling Point: 289.753 °C at 760 mmHg; (19)Vapour Pressure: 0.001 mmHg at 25°C.

Preparation: this chemical can be prepared by 2-(2-chloro-ethoxy)-ethanol. This reaction will need reagents CrO3, H2SO4 and solvent acetone. The reaction time is 6 hours with reaction temperature of 0 °C. The yield is about 77%.

Uses of Acetic acid,2-(2-chloroethoxy)-: it can be used to produce 2-Chlor-aethoxyesssigsaeure-butylester at ambient temperature. This reaction will need reagent DCC, 4-N,N-dimethylaminopyridine and solvent CH2Cl2. The yield is about 91%.

You can still convert the following datas into molecular structure:
(1)SMILES: OC(=O)COCCCl
(2)InChI: InChI=1/C4H7ClO3/c5-1-2-8-3-4(6)7/h1-3H2,(H,6,7)
(3)InChIKey: MHXJETVNZPUVEN-UHFFFAOYAR

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