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Acetyl chloride,2-(2,4-dichlorophenoxy)-

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Name

Acetyl chloride,2-(2,4-dichlorophenoxy)-

EINECS 212-268-8
CAS No. 774-74-3 Density 1.475 g/cm3
PSA 26.30000 LogP 3.13760
Solubility N/A Melting Point N/A
Formula C8H5Cl3O2 Boiling Point 296.4 °C at 760 mmHg
Molecular Weight 239.485 Flash Point 126.3 °C
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 774-74-3 (2-(2,6-DICHLOROPHENOXY)ACETYL CHLORIDE) Hazard Symbols N/A
Synonyms

Acetylchloride, (2,4-dichlorophenoxy)- (6CI,7CI,8CI,9CI);(2,4-Dichlorophenoxy)acetylchloride;2-(2,4-Dichlorophenyloxy)acetyl chloride;

Article Data 68

Acetyl chloride,2-(2,4-dichlorophenoxy)- Synthetic route

94-75-7

2,4-Dichlorophenoxyacetic acid

774-74-3

2-(2,4-dichlorophenoxy)acetyl chloride

Conditions
ConditionsYield
With thionyl chloride at 100℃; for 5h; Substitution;100%
With thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride In chloroform for 4h; Chlorination; Heating;85%
With thionyl chloride at 75℃; for 2h;80%
120-83-2

2,4-dichlorophenol

774-74-3

2-(2,4-dichlorophenoxy)acetyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 77 percent / NaOH / H2O / 3 h / 110 - 120 °C
2: SOCl2
View Scheme
Multi-step reaction with 2 steps
1: 33percent aq. NaOH / 1 h / Heating
2: SOCl2 / CHCl3 / 6 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: aq. NaOH / 0.5 h / Heating
2: SOCl2 / benzene; ethyl acetate / 6 h / Heating
View Scheme
120-83-2

2,4-dichlorophenol

sodium-salt of/the/ 3-formyl-benzenesulfonic acid

sodium-salt of/the/ 3-formyl-benzenesulfonic acid

A

774-74-3

2-(2,4-dichlorophenoxy)acetyl chloride

B

silver-salt of/the/ <2,4-dichloro-phenoxy>-acetic acid

silver-salt of/the/ <2,4-dichloro-phenoxy>-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: K2CO3; KI; PEG-600 / toluene / 1.5 h / 100 °C
1.2: 94 percent / HCl / H2O / 60 °C
2.1: 85 percent / SOCl2; benzyltriethylammonium chloride / CHCl3 / 4 h / Heating
View Scheme
3757-76-4

sodium 2,4-dichlorophenolate

774-74-3

2-(2,4-dichlorophenoxy)acetyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethyl acetate
2: thionyl chloride / 8 h / Heating
View Scheme
120-83-2

2,4-dichlorophenol

(+-)-3,4-dihydro-2H-pyran-2-carboxylic acid ethyl ester

(+-)-3,4-dihydro-2H-pyran-2-carboxylic acid ethyl ester

774-74-3

2-(2,4-dichlorophenoxy)acetyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOH / H2O / Heating
2: SOCl2 / ethyl acetate; methanol / 7 h / Heating
View Scheme

5-[2-chloro-4-(trifluoromethyl)phenoxy]benzoyl chloride

A

77207-06-8

2-hydroxyethyl 5-(2-chloro-4-trifluoromethyl phenoxy)-2-nitrobenzoate

B

774-74-3

2-(2,4-dichlorophenoxy)acetyl chloride

Conditions
ConditionsYield
With triethylamine In dichloromethane; ethylene glycol
533-23-3

ethyl 2,4-dichlorophenoxyacetate

774-74-3

2-(2,4-dichlorophenoxy)acetyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide
2: thionyl chloride / Reflux
View Scheme
1928-38-7

methyl 2,4-dichlorophenoxyacetate

774-74-3

2-(2,4-dichlorophenoxy)acetyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium hydroxide / methanol; water / 12 h / 50 °C
2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 12 h / 20 °C
View Scheme
774-74-3

2-(2,4-dichlorophenoxy)acetyl chloride

92-87-5

p,p'-diaminobiphenyl

2-(2,4-dichloro-phenoxy)-N-{4'-[2-(2,4-dichloro-phenoxy)-acetylamino]-biphenyl-4-yl}-acetamide

Conditions
ConditionsYield
With sodium hydroxide; PEG-600 In dichloromethane; water at 20℃; for 1h; Acylation;99%
119-93-7

o-tolidin

774-74-3

2-(2,4-dichlorophenoxy)acetyl chloride

2-(2,4-dichloro-phenoxy)-N-{4'-[2-(2,4-dichloro-phenoxy)-acetylamino]-3,3'-dimethyl-biphenyl-4-yl}-acetamide

Conditions
ConditionsYield
With sodium hydroxide; PEG-600 In dichloromethane; water at 20℃; for 1h; Acylation;98%

Acetyl chloride,2-(2,4-dichlorophenoxy)- Specification

The Acetyl chloride,2-(2,4-dichlorophenoxy)- is an organic compound with the formula C8H5Cl3O2. The IUPAC name of this chemical is 2-(2,4-dichlorophenoxy)acetyl chloride. With the CAS registry number 774-74-3, it is also named as 2,4-Dichlorophenoxyacetyl chloride.

Physical properties about Acetyl chloride,2-(2,4-dichlorophenoxy)- are: (1)ACD/LogP: 3.32; (2)ACD/LogD (pH 5.5): 3.32; (3)ACD/LogD (pH 7.4): 3.32; (4)ACD/BCF (pH 5.5): 195.7; (5)ACD/BCF (pH 7.4): 195.7; (6)ACD/KOC (pH 5.5): 1520.29; (7)ACD/KOC (pH 7.4): 1520.29; (8)#H bond acceptors: 2; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 26.3 Å2; (11)Index of Refraction: 1.556; (12)Molar Refractivity: 52.23 cm3; (13)Molar Volume: 162.3 cm3; (14)Polarizability: 20.7×10-24cm3; (15)Surface Tension: 44.3 dyne/cm; (16)Density: 1.475 g/cm3; (17)Flash Point: 126.3 °C; (18)Enthalpy of Vaporization: 53.62 kJ/mol; (19)Boiling Point: 296.4 °C at 760 mmHg; (20)Vapour Pressure: 0.00144 mmHg at 25°C.

Preparation: this chemical can be prepared by (2,4-dichloro-phenoxy)-acetic acid. This reaction will need reagent SOCl2.

Uses of Acetyl chloride,2-(2,4-dichlorophenoxy)-: it can be used to produce N-(2-vinyloxyethyl)-2,4-dichlorophenoxyacetamide at temperature of 40 - 45 °C. It will need reagent Et3N and solvent benzene with reaction time of 30 min. The yield is about 62%.

You can still convert the following datas into molecular structure:
(1)SMILES: Clc1cc(Cl)ccc1OCC(Cl)=O
(2)InChI: InChI=1/C8H5Cl3O2/c9-5-1-2-7(6(10)3-5)13-4-8(11)12/h1-3H,4H2
(3)InChIKey: FUJSJWRORKKPAI-UHFFFAOYAT
(4)Std. InChI: InChI=1S/C8H5Cl3O2/c9-5-1-2-7(6(10)3-5)13-4-8(11)12/h1-3H,4H2
(5)Std. InChIKey: FUJSJWRORKKPAI-UHFFFAOYSA-N

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