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| Name |
Ahr 376 |
EINECS | N/A |
| CAS No. | 13118-10-0 | Density | g/cm3 |
| PSA | 49.77000 | LogP | 3.05160 |
| Solubility | N/A | Melting Point |
164-166 °C(Solv: acetonitrile (75-05-8)) |
| Formula | C18H25 N O3 . Cl H | Boiling Point | 434.6°Cat760mmHg |
| Molecular Weight | 339.90 | Flash Point | 216.7°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects by ingestion: hallucinations, distorted perceptions, and toxic psychosis. When heated to decomposition it emits toxic fumes of NOx and HCl. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Benzeneaceticacid, a-cyclopentyl-a-hydroxy-, 1-methyl-3-pyrrolidinylester, hydrochloride (9CI); Mandelic acid, a-cyclopentyl-, 1-methyl-3-pyrrolidinyl ester,hydrochloride (6CI,7CI,8CI); 3-Pyrrolidinol, 1-methyl-, a-cyclopentylmandelate (ester),hydrochloride (8CI); 3-Pyrrolidinol, 1-methyl-, a-cyclopentylmandelate, hydrochloride;1-Methyl-3-pyrrolidyl-a-phenylcyclopentane glycolate hydrochloride; 1-Methyl-3-pyrrolidyl-a-phenylcyclopentylglycolatehydrochloride; AHR 376; NSC 172251 |
Ahr 376 Chemical Properties
Molecular Structure of Ahr 376 (CAS NO.13118-10-0):
.gif)
IUPAC Name: (1-methylpyrrolidin-3-yl) 2-cyclopentyl-2-hydroxy-2-phenylacetate
Empirical Formula: C18H25NO3
Molecular Weight: 303.396
Index of Refraction: 1.577
Surface Tension: 50.2 dyne/cm
Density: 1.17 g/cm3
Flash Point: 216.7 °C
Enthalpy of Vaporization: 72.81 kJ/mol
Boiling Point: 434.6 °C at 760 mmHg
Vapour Pressure: 2.52E-08 mmHg at 25°C
Synonyms of Ahr 376 (CAS NO.13118-10-0): 1-Methyl-3-(a-cyclopentylmandeloyloxy)pyrrolidinehydrochloride ; ahr 376 alpha-cyclopentylmandelic acid 1-methyl-3-pyrrolidinyl ester hydrochloride ; mandelic acid, alpha-cyclopentyl-,1-methyl-3-pyrrolidinyl ester, hydrochloride ; 1-Methyl-3-(-cyclopentylmandeloyloxy)pyrrolidine hydrochloride 1-Methyl-3-pyrrolidinyl -cyclopentylmandelate hydrochloride ; mandelic acid, alpha-cyclopentyl-, 1-methyl-3-pyrrolidinyl ester, hydrochloride ; 1-methyl-3-pyrrolidyl alpha-phenylcyclopentaneglycolate hydrochloride
Ahr 376 History
Raw materials:Diethyl ether-->Potassium permanganate-->Magnesium-->Bromoethane-->Styrene-->1，3-Cyclopentadiene-->Benzoylformic acid-->Methyl benzoylformate-->1-Methylpyrrolidine
Ahr 376 Toxicity Data With Reference
| 1. | orl-hmn TDLo:14 µg/kg/D | CPAJAK Canadian Psychiatric Association Journal. 11 (1966),5141. | ||
| 2. | orl-mus LD50:500 mg/kg | JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. 2 (1960),523. | ||
| 3. | ipr-mus LD50:250 mg/kg | JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. 2 (1960),523. |
Ahr 376 Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects by ingestion: hallucinations, distorted perceptions, and toxic psychosis. When heated to decomposition it emits toxic fumes of NOx and HCl.
Ahr 376 Specification
Production methods of Ahr 376 (CAS NO.13118-10-0) is potassium permanganate oxidation of styrene to produce phenyl acid, then with the participation of methanol in sulfuric acid esterification was acetophenone methyl ester, the latter with cyclopentadiene Addition (Grignard reaction, the first metal magnesium, anhydrous ether, ethyl bromide Grignard reagent is made), with α-cyclopentadienyl mandelic acid methyl ester, and thus the activity of nickel-catalyzed hydrogenation under pressure and finally with the N-methyl-pyrrolidine -3 - alcohol ester exchange obtained the goods. Ahr 376 (CAS NO.13118-10-0) can be used as a intermediate product of stomach Changning.
It is a high-toxic products, with flammable, while burning it would release of toxic nitrogen oxides and hydrogen chloride fumes, and should be stored in ventilated ,low-temperature, drying environment,besides should be kept separate with food and raw materials , dry powder, foam, sand, carbon dioxide, water mist fire-extinguishing agent can be used if emergency.
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