Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	Alfacalcidol	EINECS	255-297-1
CAS No.	41294-56-8	Density	1.01 g/cm³
PSA	40.46000	LogP	6.58980
Solubility	N/A	Melting Point	134-136 °C
Formula	C₂₇H₄₄O₂	Boiling Point	531.5 °C at 760 mmHg
Molecular Weight	400.645	Flash Point	222.6 °C
Transport Information	UN 2811 6.1/PG 1	Appearance	white powder
Safety	28-36/37-45-36-26	Risk Codes	26/27/28-36/37/38
Molecular Structure		Hazard Symbols	T+, Xi
Synonyms	9,10-Secocholesta-5,7,10(19)-triene-1,3-diol,(1a,3b,5Z,7E)- (9CI);(1S)-Hydroxycalciol;1-Hydroxyvitamin D3;1a-Hydroxycholecalciferol;1a-Hydroxyvitamin D3;Alfarol;Alpha D3;Alfacalcidolum;Alpharol;Bondiol;EinsAlpha;Etalpha;Oxydevit;Un Alfa;Un Alpha;a-Calcidol;	Article Data	37

Alfacalcidol Synthetic route

: 108887-35-0
1α,3β-bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene

: 41294-56-8
1α-hydroxyvitamin D3

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran for 2h; Heating;	98%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 55℃;	70%
With tetrabutyl ammonium fluoride In tetrahydrofuran for 4h; Yield given;

: 873567-11-4
(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

: 41294-56-8
1α-hydroxyvitamin D3

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran for 1h;	94%

: 162889-26-1
1α-di<(2-methoxyethoxy)methoxy>vitamin D3

: 41294-56-8
1α-hydroxyvitamin D3

Conditions

Conditions	Yield
With zinc dibromide In dichloromethane	91%

: 138924-22-8
(1R,3aS,7aR)-4-[2-[(3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-indene

: 41294-56-8
1α-hydroxyvitamin D3

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran for 40h; Ambient temperature;	79%
With tetrabutyl ammonium fluoride In tetrahydrofuran Ambient temperature;	79%

: 41294-56-8, 58028-00-5, 63181-13-5, 65445-15-0, 76135-93-8, 89577-10-6, 134523-94-7, 142865-40-5, 65445-14-9
1α-hydroxy-5,6-trans-vitamin D3

: 41294-56-8
1α-hydroxyvitamin D3

Conditions

Conditions	Yield
With anthracene In methanol at 20℃; for 4h; Inert atmosphere; UV-irradiation;	75%
With anthracene; triethylamine In toluene Kinetics; Concentration; Time; UV-irradiation;

: 41461-13-6
1α-hydroxyprecalciferol3

: 41294-56-8
1α-hydroxyvitamin D3

Conditions

Conditions	Yield
With potassium hydroxide In methanol at 80℃; for 24h;	64%
In benzene for 8h; Heating; Yield given;
In ethanol-d6 at 80℃; Rate constant; Equilibrium constant;

: 67657-73-2
(1S,6R)-3-deoxy-1-hydroxy-6-methoxy-3,5-cyclo-5,6-dihydrovitamin D3

: 41294-56-8
1α-hydroxyvitamin D3

Conditions

Conditions	Yield
Stage #1: (1S,6R)-3-deoxy-1-hydroxy-6-methoxy-3,5-cyclo-5,6-dihydrovitamin D3 With acetic acid In dimethyl sulfoxide at 20 - 50℃; for 1h; Inert atmosphere; Stage #2: With 4-Phenylurazole In ethyl acetate at 10℃; for 2h; Reagent/catalyst; Temperature; Inert atmosphere;	45%
Multi-step reaction with 3 steps 1: Hunig base / 5 h / Ambient temperature 2: pTsOH / dioxane; H2O / 0.08 h / 55 °C 3: 39 percent / conc. HCl / methanol / 3.5 h / 60 °C View Scheme
Multi-step reaction with 3 steps 1: 83 percent / N-ethyl diisopropylamine (Huenig's base) / CH2Cl2 / 1.) 0 deg C, 2.) room temperature, 5 h 2: 51 percent / water / toluene-p-sulphonic acid (PTSA) / dioxane / 0.08 h / 55 °C 3: 39 percent / conc. hydrochloric acid / methanol / 3.5 h / 60 °C View Scheme

: 101046-92-8
(1S)-1-methoxymethoxyvitamin D3

: 41294-56-8
1α-hydroxyvitamin D3

Conditions

Conditions	Yield
With hydrogenchloride In methanol at 60℃; for 3.5h;	39%
With hydrogenchloride In methanol at 60℃; for 3.5h;	39%

: 43217-89-6
1α,3β-dihydroxycholesta-5,7-diene

: 41294-56-8
1α-hydroxyvitamin D3

Conditions

Conditions	Yield
Stage #1: 1α,3β-dihydroxycholesta-5,7-diene In 1,4-dioxane Irradiation; Stage #2: at 100℃;	13%
In benzene Irradiation;
(i) EtOH, (UV-irradiation), (ii) (heating); Multistep reaction;

: 41461-10-3
1α,3β-diacetoxycholesta-5,7-diene

: 41294-56-8
1α-hydroxyvitamin D3

Conditions

Conditions	Yield
(i) pentane, (UV-irradiation), (ii) (isomerization), (iii) (saponification); Multistep reaction;
Multi-step reaction with 2 steps 1: aq. KOH / methanol 2: (i) EtOH, (UV-irradiation), (ii) (heating) View Scheme

Alfacalcidol Chemical Properties

Molecular Structure:

Molecular Formula: C₂₇H₄₄O₂
Molecular Weight: 400.6371
IUPAC Name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-Methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Synonyms of Alfacalcidolum (CAS NO.41294-56-8): 1alpha-Hydroxycholecalciferol ; Alfacalcidol [INN:BAN:JAN] ; (5Z,7E)-9,10-Seco-5,7,10(19)-cholestatrien-1alpha,3beta-diol ; 1-Hydroxyvitamin D3 ; 1alpha-Hydroxy-vitamin D3 ; Alfacalcidol ; Alfacalcidolum ; Alfacalcidolum [INN-Latin] ; Alfarol ; Alpha D 3 ; Alphacalcidol ; Bondiol ; CCRIS 3341 ; EB 644 ; EINECS 255-297-1 ; One-Alpha ; Oxydevit ; Sinovul ; UNII-URQ2517572 ; Un-Alpha ; alpha-Calcidol ; 9,10-Secocholesta-,7,10(19)-triene-1alpha,3beta-diol ; 9,10-Secocholesta-5,7,10(19)-triene-1,3-diol, (1-alpha,3-beta,5Z,7E)- ; 9,10-Secocholesta-5,7,10(19)-triene-1,3-diol,(1alpha,3beta,5Z,7E)-
CAS NO: 41294-56-8
Classification Code: Bone Density Conservation Agents ; Drug / Therapeutic Agent ; Reproductive Effect
Melting point: 134-136°C
Index of Refraction: 1.534
Molar Refractivity: 122.78 cm³
Molar Volume: 394.8 cm³
Surface Tension: 40.2 dyne/cm
Density: 1.01 g/cm³
Flash Point: 222.6 °C
Enthalpy of Vaporization: 92.83 kJ/mol
Boiling Point: 531.5 °C at 760 mmHg
Vapour Pressure: 1.62E-13 mmHg at 25°C

Alfacalcidol Uses

Alfacalcidolum (CAS NO.41294-56-8) is used as poultry feed additives tibial for prevention, and phytate phosphorus utilization.

Alfacalcidol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	200ug/kg (0.2mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 103, 1978.
dog	LD50	oral	500ug/kg (0.5mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 103, 1978.
mouse	LD50	intravenous	56ug/kg (0.056mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA MUSCULOSKELETAL: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Toxicology and Applied Pharmacology. Vol. 36, Pg. 323, 1976.
mouse	LD50	oral	440ug/kg (0.44mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BLOOD: CHANGES IN SPLEEN SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 560, 1977.
mouse	LD50	subcutaneous	55ug/kg (0.055mg/kg)		PCT Vol. #86-05395,
rat	LD50	intravenous	101ug/kg (0.101mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE BLOOD: CHANGES IN SPLEEN	Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 653, 1978.
rat	LD50	oral	340ug/kg (0.34mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION ENDOCRINE: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 560, 1977.
rat	LD50	subcutaneous	40ug/kg (0.04mg/kg)		PCT Vol. #86-05395,

Alfacalcidol Safety Profile

Hazard Codes Alfacalcidolum (CAS NO.41294-56-8): Very T+, Irritant Xi
Risk Statements: 26/27/28-36/37/38
R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 28-36/37-45-26
S28: After contact with skin, wash immediately with plenty of soap-suds.
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: VS2851000
F: 8-10
HazardClass: 6.1(a)
PackingGroup: I

Alfacalcidol Standards and Recommendations

The total miscellaneous：≤1.0%
Alfacalcidol Content：97.0%-102.0%

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 41294-56-8