- Benactyzine
- Benactyzine hydrochloride
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| Name |
Benactyzine hydrochloride |
EINECS | 200-324-4 |
| CAS No. | 57-37-4 | Density | 1.115g/cm3 |
| PSA | 49.77000 | LogP | 3.60950 |
| Solubility | N/A | Melting Point |
177-179 °C(lit.) |
| Formula | C20H25 N O3 . Cl H | Boiling Point | 409.3°Cat760mmHg |
| Molecular Weight | 363.884 | Flash Point | 201.4°C |
| Transport Information | UN 2811 | Appearance | N/A |
| Safety | Poison by ingestion, intraperitoneal, subcutaneous, intradermal, and intravenous routes. Human systemic effects by ingestion of very small amounts: toxic psychosis. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and HCl. | Risk Codes | R23/24/25 |
| Molecular Structure |
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Hazard Symbols |
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| Synonyms |
Benzeneaceticacid, a-hydroxy-a-phenyl-, 2-(diethylamino)ethyl ester,hydrochloride (9CI); Benzilic acid, 2-(diethylamino)ethyl ester hydrochloride(6CI,8CI); Ethanol, 2-diethylamino-, benzilate-HCl (4CI); 2-Diethylaminoethylbenzilate hydrochloride; 2-Diethylaminoethyl diphenylglycolate hydrochloride;AY 5406; AY 5406-1; Actozine; Aktozin; Amisyl; Amitakon; Amizil; Amizyl;Amyzyl; Arcadine; Arkadin; Benactyzine chloride; Benactyzine hydrochloride;Benaktin; Cafron; Cedad; Cevanol; Destendo; Fobex; Ibiotyzil; Katron; Leucidil;Lucidil; Nervacton; Nervatil; Neuraktil; Neurobenzil; Neuroleptone; Nutinal;Parasan; Parazan; Parpon; Phobex; Procalm; Prokalm; Stoikon; Suavitil;Tranquillin; Valladan; Valladon; Win 5606; b-Diethylaminoethyl benzilate hydrochloride |
Benactyzine hydrochloride Chemical Properties
IUPAC Name: 2-Diethylaminoethyl 2-hydroxy-2,2-diphenylacetate hydrochloride
Synonyms: 2-(diethylamino)-ethanobenzilatehydrochloride ; 2-(Difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid ; 2-Diethylaminoethylesterkyselinybenzilovehydrochlorid ; Aktozin ; Amisyl ; Amitakon ; Amizil ; Arkadin
Molecular Structure of Benzilic acid-β-diethylaminoethyl ester hydrochloride (CAS NO.57-37-4) : 
Molecular Formula of Benzilic acid-β-diethylaminoethyl ester hydrochloride (CAS NO.57-37-4) : C20H25NO3.HCl
Molecular Weight of Benzilic acid-β-diethylaminoethyl ester hydrochloride (CAS NO.57-37-4) : 363.88
CAS NO: 57-37-4
EINECS: 200-324-4
Mol File: 57-37-4.mol
Merck : 1029
Flash Point: 201.4 °C
Enthalpy of Vaporization: 69.75 kJ/mol
Boiling Point: 409.3 °C at 760 mmHg
Vapour Pressure: 1.96E-07 mmHg at 25°C
Melting point: 177-179 ºC
Appearance:White or almost white crystalline powder
SolubilitySoluble in water 14.9g in 100ml at 25°C, practically insoluble in ether
Benactyzine hydrochloride Uses
Benzilic acid-β-diethylaminoethyl ester hydrochloride (CAS NO.57-37-4) is usd as anticholinergics.
Benactyzine hydrochloride Production
By reaction of diphenyl glycolic acid with 1 - chloro -2 Diethylamino ethane . Methylbenzene, benzilic acid and 1 - chloro -2 - diethylamino-ethane in the reaction pot and heat, reflux 3h, cooling crystallization, Lut filter , the refining of crude is Benzilic acid-β-diethylaminoethyl ester hydrochloride (CAS NO.57-37-4) .
Benactyzine hydrochloride Toxicity Data With Reference
| 1. | orl-hmn TDLo:14 µg/kg:CNS | 27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,363. | ||
| 2. | orl-rat LD50:184 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 1 (1959),42. | ||
| 3. | ipr-rat LD50:100 mg/kg | APTOA6 Acta Pharmacologica et Toxicologica. 11 (1955),405. | ||
| 4. | orl-mus LD50:160 mg/kg | 27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,363. | ||
| 5. | ipr-mus LD50:76 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 74 (1942),274. | ||
| 6. | scu-mus LD50:250 mg/kg | 27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,363. | ||
| 7. | ivn-mus LD50:14,300 µg/kg | 28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku ,Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,253. | ||
| 8. | idr-mus LD50:350 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 59 (1938),149. | ||
| 9. | ipr-rbt LD50:100 mg/kg | APTOA6 Acta Pharmacologica et Toxicologica. 11 (1955),405. | ||
Benactyzine hydrochloride Consensus Reports
Reported in EPA TSCA Inventory.
Benactyzine hydrochloride Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous, intradermal, and intravenous routes. Human systemic effects by ingestion of very small amounts: toxic psychosis. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and HCl.
Hazard Codes
T
Risk Statements 23/24/25
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements 36/37/39-45
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS DD2800000
HazardClass 6.1(b)
PackingGroup III
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