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Berberine hydrochloride

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Berberine hydrochloride

EINECS 211-195-9
CAS No. 633-65-8 Density 1.654g/cm3
PSA 40.80000 LogP 0.10030
Solubility soluble in cold water Melting Point 204-206 °C (dec.)
Formula C20H18NO4.Cl Boiling Point N/A
Molecular Weight 371.82 Flash Point N/A
Transport Information N/A Appearance yellow crystalline powder
Safety 24/25-36-26 Risk Codes 20/21/22-36/37/38
Molecular Structure Molecular Structure of 633-65-8 (Berberine hydrochloride) Hazard Symbols HarmfulXn
Synonyms

NSC 646666;Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-, chloride (9CI);Berberine, chloride (6CI,7CI);Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-,chloride (8CI);Berberinium chloride;

Article Data 18

Berberine hydrochloride Chemical Properties

Product Name: Berberine hydrochloride (CAS NO.633-65-8)

Molecular Formula: C20H18NO4.Cl
Molecular Weight: 371.82g/mol
Mol File: 633-65-8.mol
EINECS: 211-195-9
Appearance: yellow crystalline powder
Melting Point: 204-206 °C (dec.)
H-Bond Donor: 0
H-Bond Acceptor: 5
Structure Descriptors of Berberine hydrochloride (CAS NO.633-65-8):
  Canonical SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]
  InChI: InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13
(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1 
  InChIKey: VKJGBAJNNALVAV-UHFFFAOYSA-M
Product Categories: Natural Plant Extract

Berberine hydrochloride Uses

An ingredient in some commercial eyewash products.

Berberine hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 37mg/kg (37mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Pharmacology and Experimental Therapeutics. Vol. 104, Pg. 253, 1952.
mouse LD50 oral > 29586mg/kg (29586mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 654, 1974.
mouse LD50 unreported 30mg/kg (30mg/kg)   Pharmaceutical Chemistry Journal Vol. 22, Pg. 856, 1988.
rat LD50 intravenous 60mg/kg (60mg/kg)   Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 25, Pg. 335, 1990.
rat LD50 oral > 15gm/kg (15000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 654, 1974.

Berberine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

Berberine hydrochloride Safety Profile

Safety Information of Berberine hydrochloride (CAS NO.633-65-8):
Hazard Codes: XnHarmful
Risk Statements: 20/21/22-36/37/38  
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26
S24/25:Avoid contact with skin and eyes. 
S36:Wear suitable protective clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: 1544
WGK Germany: 2
RTECS: DR9866400
F: 3-10
HazardClass: 6.1(b)
PackingGroup: III

Berberine hydrochloride Specification

 Berberine hydrochloride , its CAS NO. is 633-65-8, the synonyms are 5,6-Dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium chloride hydrate ; Benzodioxide ; Berberine chloride ; Berberinium chloride ; Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-, chloride ; Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-, chloride .

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