Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	Betaxolol	EINECS	N/A
CAS No.	63659-18-7	Density	1.067 g/cm³
PSA	50.72000	LogP	2.78430
Solubility	N/A	Melting Point	61-63 °C
Formula	C₁₈H₂₉NO₃	Boiling Point	448 °C at 760 mmHg
Molecular Weight	307.433	Flash Point	224.724 °C
Transport Information	N/A	Appearance	White crystalline solid
Safety		Risk Codes	R36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	1-Isopropylamino-3-[4-(2-cyclopropylmethoxy-ethyl)phenoxy]-2-propanol;Betaxolol;Betoptic S;	Article Data	13

Betaxolol Synthetic route

: 75-31-0
isopropylamine

: 63659-17-6
1-[2-(cyclopropyl-methoxy)-ethyl]-4-(2,3-epoxypropoxy)-benzene

: 63659-18-7
betaxolol

Conditions

Conditions	Yield
for 24h; Ambient temperature;	90%
for 48h; Heating; Yield given;
In water at 0 - 35℃;

: 884340-61-8
RS 1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol

: 75-11-6
diiodomethane

: 63659-18-7
betaxolol

Conditions

Conditions	Yield
With diethylzinc In toluene at 0℃; for 16h;	84%

: 2-Phenyl-3-isopropyl-5-[[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]methyl]oxazolidine

: 63659-18-7
betaxolol

Conditions

Conditions	Yield
With hydrogenchloride In isopropyl alcohol	74%

: 63659-16-5
4-[2-(cyclopropylmethoxy)-ethyl]-phenol

: 63659-18-7
betaxolol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaOH / H2O / 12 h / Ambient temperature 2: 48 h / Heating View Scheme

: 63659-15-4
1-benzyloxy-4-(2-cyclopropylmethoxyethyl)benzene

: 63659-18-7
betaxolol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 84 percent / H2 / 5percent Pd/C / tetrahydrofuran / 50 - 60 °C / 2585.7 Torr 2: NaOH / H2O / 12 h / Ambient temperature 3: 48 h / Heating View Scheme

: 61439-59-6
2-(4-benzyloxyphenyl)ethanol

: 63659-18-7
betaxolol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 1.) NaH / 1.) DMF, 2.) DMF, 60 deg, 18 h 2: 84 percent / H2 / 5percent Pd/C / tetrahydrofuran / 50 - 60 °C / 2585.7 Torr 3: NaOH / H2O / 12 h / Ambient temperature 4: 48 h / Heating View Scheme

: 56441-69-1
2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester

: 63659-18-7
betaxolol

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 86 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature 2: 1.) NaH / 1.) DMF, 2.) DMF, 60 deg, 18 h 3: 84 percent / H2 / 5percent Pd/C / tetrahydrofuran / 50 - 60 °C / 2585.7 Torr 4: NaOH / H2O / 12 h / Ambient temperature 5: 48 h / Heating View Scheme

: 63659-19-8
betaxolol Hydrochloride

: 63659-18-7
betaxolol

Conditions

Conditions	Yield
With Dowex Marathon 11 chloride form In water

: 63659-18-7
betaxolol

: 108-24-7
acetic anhydride

: 169613-96-1
1-(N-acetyl-N-isopropyl)amino-3-<4-(2-cyclopropylmethoxy)ethyl>phenoxyprop-2-yl acetate

Conditions

Conditions	Yield
With pyridine for 24h; Ambient temperature;	100%
With pyridine; triethylamine at 20℃;

: 63659-18-7
betaxolol

: 108-24-7
acetic anhydride

A: N-{(R)-3-[4-(2-Cyclopropylmethoxy-ethyl)-phenoxy]-2-hydroxy-propyl}-N-isopropyl-acetamide

B: 169613-97-2
Acetic acid (S)-2-(acetyl-isopropyl-amino)-1-[4-(2-cyclopropylmethoxy-ethyl)-phenoxymethyl]-ethyl ester

Conditions

Conditions	Yield
With pyridine for 24h; Ambient temperature; Yield given. Yields of byproduct given;

Betaxolol Chemical Properties

Molecular Formula: C₁₈H₂₉NO₃
Molar mass: 307.43 g/mol
Density: 1.067 g/cm³
Flash Point: 224.7 °C
Index of Refraction: 1.529
Boiling Point: 448 °C at 760 mmHg
Vapour Pressure: 8.26E-09 mmHg at 25°C
Melting point: 61-63°C
Appearance: White crystalline solid
Product categories of Betaxolol (63659-18-7): Pharmaceuticals;Intermediates & Fine Chemicals;Steroids
Structure of Betaxolol (63659-18-7):

Systematic Name: 1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)propan-2-ol
SMILES: O(CCc1ccc(OCC(O)CNC(C)C)cc1)CC2CC2
InChI: InChI=1/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3
InChIKey: NWIUTZDMDHAVTP-UHFFFAOYAU
Std. InChI: InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3
Std. InChIKey: NWIUTZDMDHAVTP-UHFFFAOYSA-N

Betaxolol History

Betaxolol (63659-18-7) was approved Drug Administration (FDA) by and the U.S. Food for ocular use as a 0.5% solution (Betoptic) in 1985 and as a 0.25% solution (Betoptic S) in 1989.

Betaxolol Uses

Betaxolol (63659-18-7) is a selective beta1 receptor blocker used in the treatment of hypertension and glaucoma. And it can be used for the management of hypertension and for the management of glaucoma .

Betaxolol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	60mg/kg (60mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,

Betaxolol Specification

Betaxolol (63659-18-7) also can be called Betoptic , Betoptic S , Lokren ,and Kerlone .It typically has fewer systemic side effects than non-selective beta-blockers, for example, not causing bronchospasm (mediated by beta2 receptors) as timolol may.In addition to its effect on the heart, betaxolol reduces the pressure within the eye (intraocular pressure). This effect is thought to be caused by reducing the production of the liquid (which is called the aqueous humor) within the eye. The precise mechanism of this effect is not known. The reduction in intraocular pressure reduces the risk of damage to the optic nerve and loss of vision in patients with elevated intraocular pressure due to glaucoma.It also shows greater affininty for beta1 receptors than metoprolol.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 63659-18-7