1. Introduction of Bimatoprost
Bimatoprost is crystalline solid. The Product Categories of this chemical is Prostaglandins; Prostaglandin; Chiral Reagents; Intermediates & Fine Chemicals; Pharmaceuticals; Arachidonic Acid Cascade; Lipids in Cell Signaling. The Classification Code of Bimatoprost is Antiglaucoma agent; Antihypertensive Agents; Cardiovascular Agents; Lowers intraocular pressure [IOP] in patients with open angle glaucoma or ocular hypertension [synthetic prostamide analog]. It should be store at -20 °C. Bimatoprost is very soluble in ethanol and methanol, and slightly soluble in water.

2. Properties of Bimatoprost
Physical properties about Bimatoprost are:
(1)H bond acceptors: 5; (2)H bond donors: 4; (3)Freely Rotating Bonds: 15; (4)Index of Refraction: 1.591; (5)Molar Refractivity: 122.67 cm³; (6)Molar Volume: 362.8 cm³; (7)Surface Tension: 48 dyne/cm; (8)Density: 1.145 g/cm³; (9)Flash Point: 334.7 °C; (10)Enthalpy of Vaporization: 97.93 kJ/mol; (11)Boiling Point: 629.8 °C at 760 mmHg; (12)Vapour Pressure: 9.94E-17 mmHg at 25 °C.

3. Structure Descriptors of Bimatoprost
(1)Canonical SMILES: CCNC(=O)CCCC=CCC1C(CC(C1C=CC(CCC2=CC=CC=C2)O)O)O
(2)Isomeric SMILES: CCNC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](CCC2=CC=CC=C2)O)O)O
(3)InChI: InChI=1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1
(4)InChIKey: AQOKCDNYWBIDND-FTOWTWDKSA-N

4. Safety Information of Bimatoprost
WGK Germany: 3

5. Uses of Bimatoprost
Bimatoprost (CAS NO.155206-00-1) is used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. As an antiglaucoma, Bimatoprost can be used to synthetic prostamide or structurally related to prostaglandin F2α. Usually, it has been used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It can be used in the cosmetic use. In 2008-2011, at least three case series suggested that bimatoprost has the ability to reduce adipose (fat) tissue.

6. Production of Bimatoprost
(3AR, 4R, 5R, 6AS)-six hydrogen-4-(3-oxygen-5-phenyl-1 e-pentenyl)-5-(p-phenyl butyryl oxygen base)-2 h-ring pentaerythritol and [b] furan-2-ketone can be used to manufacture the Bimatoprost. The detailed steps of it is:
By the reduction reaction, and then to restore the carbonyl group on the furan ring is hydroxy, the hydrolysis before and valeric triphenylphosphine to afford 7-(1R, 2R, 3R, 5S) -3,5-two hydroxy-2 -[(3S) -5-phenyl-3-[(tetrahydro-2-H-pyran-2-yl)-oxygen]-1E-pentenyl] cyclopentyl]-5Z-heptenoic acid. Hydrolysis stripped pentenyl the protecting group on the hydroxyl group of the side chain. Was dissolved in dimethyl formamide and then iodomethane, Cs2CO3 role methyl, and finally reaction with the aqueous solution of ethylamine to get this product.