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Cas Database |
| Name |
Bis(2-chloroethyl)amine hydrochloride |
EINECS | 212-479-5 |
| CAS No. | 821-48-7 | Density | 1.125 g/cm3 |
| PSA | 12.03000 | LogP | 2.24650 |
| Solubility | soluble in water | Melting Point |
212-214 °C(lit.) |
| Formula | C4H9Cl2N.HCl | Boiling Point | 204.2 °C at 760 mmHg |
| Molecular Weight | 178.489 | Flash Point | 77.3 °C |
| Transport Information | UN 2811 | Appearance | white to light beige powder |
| Safety | 26-45-36/37/39-27 | Risk Codes | 36/37/38-36-34 |
| Molecular Structure |
|
Hazard Symbols |
 Xi,  T,  C
|
| Synonyms |
N,N-Bis(2-chloroethyl)amine hydrochloride;NSC 10873;Nornitrogen mustard hydrochloride;b,b'-Dichlorodiethylamine hydrochloride;Diethylamine,2,2'-dichloro-, hydrochloride (6CI,8CI);Ethanamine, 2-chloro-N-(2-chloroethyl)-,hydrochloride (9CI);1,5-Dichloro-3-azapentane hydrochloride;2,2'-Dichlorodiethylamine hydrochloride;2-Chloro-N-(2-chloroethyl)ethanaminehydrochloride;Bis(2-chloroethyl)amine hydrochloride;Bis(2-chloroethyl)ammonium chloride;Bis(b-chloroethyl)aminehydrochloride;Leo 72a; |
Article Data | 38 |
Bis(2-chloroethyl)amine hydrochloride Synthetic route
| Conditions | Yield |
|---|---|
| With thionyl chloride In 1,2-dichloro-ethane at 50℃; for 3h; | 100% |
| With thionyl chloride In dichloromethane for 24h; | 100% |
| With thionyl chloride In chloroform at 50℃; for 4h; Temperature; | 98.8% |
| Conditions | Yield |
|---|---|
| With hydrogenchloride at 37℃; pH 1.2; |
- 15567-79-0
N,N,N',N'-tetrakis(2-chloroethyl)methanediamine
- 821-48-7
bis-(2-chloroethyl)amine hydrochloride
| Conditions | Yield |
|---|---|
| With acetyl chloride In dichloromethane Cooling; |
- 821-48-7
bis-(2-chloroethyl)amine hydrochloride
- 127-88-8
N,N-di(2-chloroethyl)amidophosphoric acid dichloride
| Conditions | Yield |
|---|---|
| With trichlorophosphate for 75h; Heating; | 100% |
| With trichlorophosphate | 100% |
| With trichlorophosphate Heating; | 93% |
- 821-48-7
bis-(2-chloroethyl)amine hydrochloride
- 541-41-3
chloroformic acid ethyl ester
- 5467-15-2
bis(2-chloroethyl)carbamic acid ether
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetone for 4h; Heating / reflux; | 100% |
| With triethylamine In dichloromethane at 0℃; for 1.5h; | 99% |
| With triethylamine In dichloromethane at 0℃; for 1.5h; | 99% |
| With sodium hydroxide; water at 7 - 10℃; |
- 821-48-7
bis-(2-chloroethyl)amine hydrochloride
- 124-63-0
methanesulfonyl chloride
- 54533-09-4
N,N-bis(2-chloroethyl)methanesulfonamide
| Conditions | Yield |
|---|---|
| With triethylamine In dichloromethane at 0 - 20℃; for 15h; | 100% |
| With triethylamine In dichloromethane at 20℃; for 3h; | 94% |
| Stage #1: bis-(2-chloroethyl)amine hydrochloride With triethylamine In dichloromethane Stage #2: methanesulfonyl chloride In dichloromethane at 20℃; for 3h; | 94% |
- 50-00-0
formaldehyd
- 821-48-7
bis-(2-chloroethyl)amine hydrochloride
- 55-86-7
mechlorethamine hydrochloride
| Conditions | Yield |
|---|---|
| With formic acid at 100 - 120℃; for 3.33333h; | 100% |
| With formic acid In water at 100 - 120℃; for 3.33333h; Heating / reflux; | 100% |
| With formic acid In water at 100 - 120℃; for 3.33333h; | 100% |
| With formic acid In water 1a.) 100 deg C, 3 h, 1b.) 120 deg C, 20 min; Yield given; |
- 24424-99-5
di-tert-butyl dicarbonate
- 821-48-7
bis-(2-chloroethyl)amine hydrochloride
- 118753-70-1
N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine
| Conditions | Yield |
|---|---|
| With triethylamine | 100% |
| In dichloromethane | 100% |
| With sodium hydroxide In dichloromethane at 20℃; for 18.5h; | 100% |
- 821-48-7
bis-(2-chloroethyl)amine hydrochloride
- 851627-23-1
2-[bis(2-chloroethyl)amino]-N-(3-hydroxypropyl)-3,5-dinitrobenzamide
| Conditions | Yield |
|---|---|
| With triethylamine In 1,4-dioxane at 50℃; for 24h; | 100% |
- 851627-28-6
2-chloro-N-(4-hydroxybutyl)-3,5-dinitrobenzamide
- 821-48-7
bis-(2-chloroethyl)amine hydrochloride
| Conditions | Yield |
|---|---|
| With triethylamine In 1,4-dioxane at 50℃; for 24h; | 100% |
Bis(2-chloroethyl)amine hydrochloride Chemical Properties
Bis(2-chloroethyl) (CAS NO.821-48-7) amine hydrochloride can be also named as 2,2'-dichloro-diethylaminhydrochloride;2-chloro-n-(2-chloroethyl)ethanaminehydrochloride;2-chloro-n-(2-chloroethyl)-ethanaminhydrochloride;2-Chloro-N-(2-chlorethyl)-ethanamine, Hydrochloride; Bis-(2-chlorethyl)-amine HCl; 2-chloro-N-(2-chloroethyl)ethanamine hydrochloride,and so on.Bis(2-chloroethyl)amine hydrochloride is usually white to light beige powder.
CAS: 821-48-7
Molecular Formula: C4H10Cl3N
Molecular Weight: 178.49
EINECS: 212-479-5
Molecular structure: 
Melting point: 212-214 °C(lit.)
Water Solubility: Soluble
Sensitive: Hygroscopic
BRN: 3550356
Bis(2-chloroethyl)amine hydrochloride Uses
Bis(2-chloroethyl) (CAS NO.821-48-7) is commonly used as a pharmaceutical intermediate.
Bis(2-chloroethyl)amine hydrochloride Toxicity Data With Reference
| 1. | hmn-lym 1 mg/L | CRNGDP Carcinogenesis. 5 (1984),163. | ||
| 2. | hmn-lym 250 µg/L | CRNGDP Carcinogenesis. 5 (1984),163. | ||
| 3. | mmo-sat 50 µg/plate | PNASA6 Proceedings of the National Academy of Sciences of the United States of America. 72 (1975),979. | ||
| 4. | ipr-rat LD50:100 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),143. | ||
| 5. | ims-rat LD50:160 mg/kg | ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. 84 (1975),227. | ||
| 6. | ihl-mus LCLo:1000 mg/m3/10M | NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report NDCrc-132,July (1942). | ||
| 7. | scu-mus LD50:20 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 91 (1947),224. |
RTECS: IA1225000
Bis(2-chloroethyl)amine hydrochloride Consensus Reports
EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.
Bis(2-chloroethyl)amine hydrochloride Safety Profile
A poison by inhalation, intraperitoneal, intramuscular, and subcutaneous routes. An experimental teratogen. Human mutation data reported. When heated to decomposition it emits toxic fumes of NH3, NOx, and Cl−.
Hazard Codes: Xi
,T
,C
Risk Statements: 36/37/38-36-34
R36/37/38:Irritating to eyes, respiratory system and skin.
R36:Irritating to eyes.
R34:Causes burns.
Safety Statements: 26-45-36/37/39-27
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S27:Take off immediately all contaminated clothing.
RIDADR: 2811
WGK Germany: 3
Hazard Note: Irritant/Toxic
HazardClass: 8
PackingGroup: III
HS Code: 29211980
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