- In-Depth Assessment of the Palladium-Catalyzed Fluorination of Five-Membered Heteroaryl Bromides
-
A thorough investigation of the challenging Pd-catalyzed fluorination of five-membered heteroaryl bromides is presented. Crystallographic studies and density functional theory (DFT) calculations suggest that the challenging step of this transformation is
- Milner, Phillip J.,Yang, Yang,Buchwald, Stephen L.
-
supporting information
p. 4775 - 4780
(2015/10/28)
-
- Direct arylation of thiazoles on water
-
Wetter is better: The direct arylation of thiazoles on water is quicker, cleaner, and higher-yielding than arylation in organic solvents. The reaction works under mild conditions for an array of aryl iodides, producing 2,5-diaryl thiazoles in excellent yields. Importantly, novel bi-heteroaryl compounds are produced without the requirement for stoichiometric organometallic coupling agents. (Figure Presented).
- Turner, Gemma L.,Morris, James A.,Greaney, Michael F.
-
p. 7996 - 8000
(2008/09/17)
-