- A 2 - (6-hydroxy -2,3-dihydrobenzo-furan-3-yl) acetonitrile TAK-875 compound preparation compound and method
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The present invention particularly relates to a chiral compound 2-(6-hydroxy-2,3-dihydro benzofuran-3-yl)acetonitrile and a preparation method thereof, and a method for preparing a TAK-875 drug by adopting the compound as an intermediate. Compared with the TAK-875 synthesis method reported in the literature, the method for preparing the TAK-875 by adopting the chiral compound 2-(6-hydroxy-2,3-dihydro benzofuran-3-yl)acetonitrile in the present invention has the following advantages that: the single maximum impurity, the content, the yield, the optical purity and other characteristics of the obtained TAK-875 in the present invention are superior to the TAK-875 obtained through the method in the literature, and the method is suitable for industrial mass production.
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- PRODUCTION METHOD OF OPTICALLY ACTIVE DIHYDROBENZOFURAN DERIVATIVE
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Provided is a production method of an optically active dihydrobenzofuran derivative. A production method of an optically active form of a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof and the like.
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Page/Page column 173-174
(2012/09/10)
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- FUSED CYCLIC COMPOUNDS
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The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof. The compound or a salt thereof or a prodrug thereof has a GPR40 receptor function modulating action and is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.
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Page/Page column 115-116
(2008/06/13)
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