Regio- and Stereoselective Control in the Addition of Grignard Reagents to the Pyridine Ring System
The N-methyl and N-benzyl salts of nicotinic acid derivative 7a (e.g., 8 and 9) undergo regio- and stereoselective addition with Grignard reagents to give 10 as the major reaction product.Selectivities as high as >99:1 are observed.Addition of alkyllithiu
Schulz, Arthur G.,Flood, Lawrence,Springer, James P.
p. 838 - 841
(2007/10/02)
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