Design, synthesis, and biological evaluation of 2-substituted-2,3,4,9-tetrahydrospiro-β-carboline-3-carboxylic acid derivatives as first-in-class mast cell stabilizers
Mast cell degranulation plays a momentous role in myriad diseases like asthma, eczema, allergic rhinitis, and conjunctivitis as well as anaphylactic shock; hence, there is an unmet need for developing new mast cells stabilizers. The reported mast cell sta
Application of chlorotrimethylsilane in Pictet-Spengler reaction
Chlorotrimethylsilane has been found to be an efficient condensing agent in the Pictet-Spengler reaction, affording an extremely straightforward synthetic route to tetrahydro-β-carboline derivatives and their analogs. The applicability of the method has b
Pictet-Spengler Reactions of Tryptamine and Tryptophan with Cycloalkanones and Ketonic Mannich Bases
A Pictet-Spengler reaction of tryptamine (1) with cyclopentanone under physiological conditions gave 3-(cyclopentylideneaminoethyl)indole (3), which was cyclized to the 1-spirocyclic 1,2,3,4-tetrahydro-2-carboline (4).Treatment of (+/-)-tryptophan with cy
Afsah, E.M.,Hammouda, M.,Hamama, W.S.
p. 851 - 856
(2007/10/02)
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