- Heteroleptic Copper(I)-Based Complexes for Photocatalysis: Combinatorial Assembly, Discovery, and Optimization
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A library of 50 copper-based complexes derived from bisphosphines and diamines was prepared and evaluated in three mechanistically distinct photocatalytic reactions. In all cases, a copper-based catalyst was identified to afford high yields, where new heteroleptic complexes derived from the bisphosphine BINAP displayed high efficiency across all reaction types. Importantly, the evaluation of the library of copper complexes revealed that even when photophysical data is available, it is not always possible to predict which catalyst structure will be efficient or inefficient in a given process, emphasizing the advantages for catalyst structures with high modularity and structural variability.
- Minozzi, Clémentine,Caron, Antoine,Grenier-Petel, Jean-Christophe,Santandrea, Jeffrey,Collins, Shawn K.
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supporting information
p. 5477 - 5481
(2018/05/01)
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- Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates
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An efficient, safe and scalable procedure for the continuous flow thermolysis of azidoacrylates to yield indoles has been developed and was applied to the synthesis of related heterocycles. The scalability of the process was demonstrated in the continuous flow synthesis of a precursor to the DAAO inhibitor 4H-furo[3,2-b]pyrrole-5-carboxylic acid.
- O'Brien, Alexander G.,Levesque, Francois,Seeberger, Peter H.
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supporting information; experimental part
p. 2688 - 2690
(2011/04/25)
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- Transition metal-catalyzed synthesis of pyrroles from dienyl azides
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(Chemical Equation Presented) A range of 2,5-disubstituted and 2,4,5-trisubstituted pyrroles can be synthesized from dienyl azides at room temperature using catalytic amounts of Znl2 or Rh2(O 2CC3F7)4.
- Dong, Huijun,Shen, Meihua,Redford, Joanne E.,Stokes, Benjamin J.,Pumphrey, Ashley L.,Driver, Tom G.
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p. 5191 - 5194
(2008/09/17)
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