- Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists
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We have identified and synthesized a series of 2,7-diamino-thiazolo[5,4-d]pyrimidines as TRPV1 antagonists. An exploration of the structure-activity relationships at the 2-, 5-, and 7-positions of the thiazolo[5,4-d]pyrimidine led to the identification of
- Lebsack, Alec D.,Branstetter, Bryan J.,Hack, Michael D.,Xiao, Wei,Peterson, Matthew L.,Nasser, Nadia,Maher, Michael P.,Ao, Hong,Bhattacharya, Anindya,Kansagara, Mena,Scott, Brian P.,Luo, Lin,Rynberg, Raymond,Rizzolio, Michele,Chaplan, Sandra R.,Wickenden, Alan D.,Guy Breitenbucher
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scheme or table
p. 40 - 46
(2009/04/10)
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- Thiazolopyrimidine modulators of TRPV1
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Certain TRPV1-modulating thiazolopyrimidine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease.
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Page/Page column 12
(2008/06/13)
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