Bifunctional, pH-activatable BODIPY dyes were developed and incorporated in mannose cluster-containing activity-based probes for cysteine proteases. Mannose receptor-dependent uptake of the probes in dendritic cells, followed by trafficking to acidic cellular compartments resulted in fluorescence as seen by live-cell imaging, and subsequent cathepsin inhibition.
Hoogendoorn, Sascha,Habets, Kim L.,Passemard, Solene,Kuiper, Johan,Van Der Marel, Gijsbert A.,Florea, Bogdan I.,Overkleeft, Herman S.
supporting information; experimental part
p. 9363 - 9365
(2011/10/03)
PH-SENSITIVE FLUORESCENT PROBE
A compound represented by the following general formula (I): wherein R1 represents an amino group which may be substituted with one or two alkyl groups; R2, R3, R4 and R5 independently represent an al
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Page/Page column 5; 7
(2009/09/26)
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