Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7
A high-throughput screening campaign identified a number of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7. Further synthetic chemistry efforts enabled the preparation of a number of analogues with promising in vitro potencies. Although these compounds show likely broad spectrum inhibitory activity, they represent a useful starting point for further chemical optimisation.
Bouloc, Nathalie,Large, Jonathan M.,Smiljanic, Ela,Whalley, David,Ansell, Keith H.,Edlin, Christopher D.,Bryans, Justin S.
scheme or table
p. 5294 - 5298
(2009/05/08)
Novel Compounds
There is provided a compound of formula (I): processes for the manufacture thereof, pharmaceutical compositions thereof and uses in therapy.
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Page/Page column 70
(2008/06/13)
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