- Efficient and scalable synthesis of pyridine sulfonamides
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Short-step and scalable transformations from 2,6-dibromopyridine to 6-bromopyridine-2-sulfonamide by means of halogen-metal exchange and subsequent reaction with sulfuryl chloride followed by amidation are established. Application of the method for the synthesis of various pyridine sulfonamides is also described. Georg Thieme Verlag Stuttgart - New York.
- Emura, Takashi,Yoshino, Hitoshi,Tachibana, Kazutaka,Shiraishi, Takuya,Honma, Akie,Mizutani, Akemi,Muraoka, Terushige
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- NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS
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The present invention relates to compounds of formula (I) wherein Q is selected from O or S; R1 is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R1 is attached to the sulfur atom of the sulfonylurea group by a ring carbon atom, and wherein R1 may optionally be substituted; and R2 is a cyclic group substituted at the α-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.
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Page/Page column 208; 209
(2019/01/21)
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- TRIAZOLOPYRIDINE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
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The invention relates to a compound of Formula I or IA and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof:
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Paragraph 0108; 0109
(2016/05/02)
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- PYRIDYL-AMINE FUSED AZADECALIN MODULATORS
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The present invention provides a novel class of pyridyl-amine fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
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Page/Page column 86-87
(2012/03/26)
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