Synthesis and evaluation of novel heterocyclic MMP inhibitors
A variety of novel heterocyclic compounds were synthesized and evaluated for MMP inhibition. Broad spectrum inhibition of MMPs 1, 2, 9, and 12 was found with pyridinone-based compounds while N-heterocyclic triazoles and tetrazoles were largely ineffective. A highly selective tetrazole inhibitor for MMP-2 was discovered.
Hayashi, Ryuji,Jin, Xiaomin,Cook, Gregory R.
p. 6864 - 6870
(2008/09/18)
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