cas 1000994-95-5, Benzene, 1-bromo-4-(1,1-difluoroethyl)-

Articles about 1000994-95-5Total 11 be found

Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4)
A general approach to fluorinated (hetero)aromatic derivatives is elaborated. The key reaction is a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation is fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chemistry and agrochemistry, were synthesized.
Ahunovych, Volodymyr,Boretskyi, Andrii,Bugera, Maksym,Klipkov, Anton A.,Mykhailiuk, Pavel K.,Razhyk, Bohdan,Semenov, Sergey,Tarasenko, Karen,Trofymchuk, Serhii
p. 12181 - 12198
(2021/09/13)

Copper-Catalyzed Functionalization of Benzylic C-H Bonds with N-Fluorobenzenesulfonimide: Switch from C-N to C-F Bond Formation Promoted by a Redox Buffer and Br?nsted Base
A copper catalyst in combination with N-fluorobenzenesulfonimide (NFSI) has been reported to functionalize benzylic C-H bonds to the corresponding benzylic sulfonimides via C-N coupling. Here, we reported a closely related Cu-catalyzed method with NFSI that instead leads to C-F coupling. This switch in selectivity arises from changes to the reaction conditions (Cu/ligand ratio, temperature, addition of base) and further benefits from inclusion of MeB(OH)2 in the reaction. MeB(OH)2 is shown to serve as a "redox buffer"in the reaction, responsible for rescuing inactive Cu(II) for continued promotion of fluorination reactivity.
Buss, Joshua A.,Golden, Dung L.,Stahl, Shannon S.,Vasilopoulos, Aristidis
supporting information
p. 5749 - 5752
(2020/10/02)

Copper-Mediated Aromatic 1,1-Difluoroethylation with (1,1-Difluoroethyl)trimethylsilane (TMSCF2CH3)
A new method for the formation of 1,1-difluoroethyl copper species (“CuCF2CH3”) with 1,1-difluoroethylsilane (TMSCF2CH3) has been developed. The “CuCF2CH3” species can be applied to the efficient 1,1-difluoroethylation of diaryliodonium salts under mild conditions, affording (1,1-difluoroethyl)arenes in good to excellent yields. This convenient procedure tolerates a wide range of functional groups and thus serves as a practical synthetic tool for the introduction of CF2CH3 group(s) into complex molecules.
Li, Xinjin,Zhao, Jingwei,Wang, Yunze,Rong, Jian,Hu, Mingyou,Chen, Dingben,Xiao, Pan,Ni, Chuanfa,Wang, Limin,Hu, Jinbo
p. 1789 - 1792
(2016/07/07)

Benzobis(thiadiazole) derivative and organic electronics device comprising same
A benzobis(thiadiazole) derivative represented by the formula (1): in which R represents a group containing at least one fluorine atom (with the proviso that fluorine atom (F) and trifluoromethyl group (—CF3) are excluded), and m represents an integer of from 1 to 10.
-
Page/Page column 41

(2016/04/20)

METHOD FOR PRODUCING 1,1-DIFLUOROALKYL-AROMATIC COMPOUND
PROBLEM TO BE SOLVED: To provide a method for producing a 1,1-difluoroalkyl-aromatic compound, using an economical fluorinating agent which, when being handled, does not require any particular attention nor any special reactor. SOLUTION: Provided is an economical and safe method for producing a 1,1-difluoroalkyl-aromatic compound represented by formula (III) by reacting a [difluoro(trimethylsilyl)methyl]-aromatic compound represented by formula (I) (R1 represents a halogen group or a trimethylsilyl group) with a halogenated alkyl represented by formula (II) (R2 represents a C1-3 alkyl; and X represents a halogen group) in the presence of potassium fluoride. COPYRIGHT: (C)2015,JPOandINPIT
-
Paragraph 0028

(2020/10/19)

2-PYRIDONE COMPOUND
This 2-pyridone compound represented by formula [1] or a tautomer of said compound, or a pharmaceutically acceptable salt of said compound or said tautomer, or a solvate of said compound or the like has a superior GK-activating effect and is useful as a p
-
Paragraph 0110; 0111

(2015/11/16)

METALLOENZYME INHIBITOR COMPOUNDS AS FUNGICIDES
The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases disorders or symptoms thereof mediated by such metalloenzymes.
-
Paragraph 00211

(2015/11/09)

BENZOBIS(THIADIAZOLE) DERIVATIVE AND ORGANIC ELECTRONICS DEVICE USING SAME
The present invention relates to a benzobis(thiadiazole) derivative represented by the formula (1): wherein R represents a group containing at least one fluorine atom (with the proviso that fluorine atom (F) and trifluoromethyl group (-CF3) are excluded), and m represents an integer of from 1 to 10.
-
Paragraph 0133; 0134

(2015/02/25)

Substituted 1-benzylcycloalkylcarboxylic acids and the use thereof
The present application relates to novel substituted 1-benzylcycloalkylcarboxylic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
-
Page/Page column 34

(2012/07/14)

SUBSTITUTED PIPERIDINES
The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and tumour disorders.
-
Page/Page column 34-35

(2011/02/18)

SUBSTITUTED PIPERIDINES
The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular diseases and tumour diseases.
-
Page/Page column 26

(2010/12/29)