Synthesis of 1-amino-2-vinylcyclopropane-1-phosphinates. Conversion of a phosphonate to phosphinates
Conversion of diethyl 1-amino-2-vinylcyclopropanephosphonate to ethyl 1-amino-2-vinylcyclopropanephosphinate was accomplished by using either nucleophilic or electrophilic carbon reagents. Hydrolysis of the phosphonate diethyl ester to the mono acid follo
Pyun, Hyung-Jung,Clarke, Michael O.,Cho, Aesop,Casarez, Anthony,Ji, Mingzhe,Fardis, Maria,Pastor, Richard,Sheng, X. Christopher,Kim, Choung U.
experimental part
p. 2360 - 2363
(2012/07/14)
ANTIVIRAL PHOSPHINATE COMPOUNDS
The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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Page/Page column 171-173
(2008/06/13)
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