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1001264-89-6

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Articles about 1001264-89-6Total 3 be found

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Synthesis of Akt inhibitor ipatasertib. part 2. Total synthesis and first kilogram scale-up
Herein, the first-generation process to manufacture Akt inhibitor Ipatasertib through a late-stage convergent coupling of two challenging chiral components on multikilogram scale is described. The first of the two key components is a trans-substituted cyc
Remarchuk, Travis,St-Jean, Frederic,Carrera, Diane,Savage, Scott,Yajima, Herbert,Wong, Brian,Babu, Srinivasan,Deese, Alan,Stults, Jeffrey,Dong, Michael W.,Askin, David,Lane, Jonathan W.,Spencer, Keith L.
p. 1652 - 1666
(2015/02/19)

COMBINATIONS OF AKT INHIBITOR COMPOUNDS AND VEMURAFENIB, AND METHODS OF USE
The invention provides a combination of a) a compound of Formula Ia: [insert Formula Ia], or a pharmaceutically acceptable salt thereof, and b) vemurafenib or a pharmaceutically acceptable salt thereof for the prophylactic or therapeutic treatment of a hy
-
Page/Page column 80-81

(2012/10/18)

HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS
The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I). Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
-
Page/Page column 136

(2008/06/13)

More Articles about upstream products of 1001264-89-6

Chemical Properties

Appearance/Colour :Peach Solid
Melting Point: >106°C (dec.)
Boiling Point: 669.4±55.0 °C(Predicted)
Density: 1.254
Solubility:Soluble in DMSO.
Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere
PKA: 13.11±0.40(Predicted)
PSA: 81.59000
LogP: 3.49480

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