Synthesis of Succinonitrile Derivatives by Homocoupling from Cyanohydrin Derivatives with a Low-Valent Titanium Reagent
A method is described for synthesizing succinonitrile derivatives bearing alkyl or aryl substituents from cyanohydrin derivatives using low-valent titanium. The active species in this reaction is proposed to be a resonance hybrid of the TiIV nitrile enolate and TiIII alkyl radical.
An R-selective hydroxynitrile lyase from Arabidopsis thaliana with an α/β-hydrolase fold
Folding and selectivity: The noncyanogenic plant Arabidopsis thaliana contains a new hydroxynitrile lyase, which was cloned and characterized. This enzyme is readily available form a recombinant source, has a broad range of substrates, and enantioselectively transforms aliphatic and aromatic aldehydes as well as ketones into the corresponding R-cyanohydrins. (Chemical Equation Presented).
Andexer, Jennifer,Von Langermann, Jan,Mell, Annett,Bocola, Marco,Kragl, Udo,Eggert, Thorsten,Pohl, Martina
p. 8679 - 8681
(2008/09/18)
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