Synthesis of 3′,3′-difluoro-2′-hydroxymethyl-4′, 5′-unsaturated carbocyclic nucleosides
3′,3′-Difluoro-2′-hydroxymethyl-4′, 5′-unsaturated carbocyclic nucleosides 1-3 have been stereoselectively synthesized from ester 10, which can be conveniently prepared from 2,3-isopropylidene-D-glyceraldehyde 7 in five steps. The whole synthesis highligh