THE NUCLEOPHILIC AROMATIC PHOTOSUBSTITUTION IN PHOTOAFFINITY LABELLING. A MODEL STUDY OF A CYCLOHEXIMIDE DERIVATIVE.
The photoreactions of several 4-nitrocatechol ethers with the relatively hard nucleophile methylamine occurs at the meta position respect to the nitro group.A derivative of the antibiotic cycloheximide carrying a 4-nitrocatechol ether moiety reacts with methylamine affording an in vitro model for photoaffinity labelling.