1002355-96-5

Basic information

• Product Name: 3-Ethoxycarbonylmethylene-azetidine-1-carboxylic acid tert-butyl ester
• Synonyms: 3-Ethoxycarbonylmethylene-azetidine-1-carboxylic acid tert-butyl ester;1-Boc-3-ethoxycarbonylMethylene-azetidine;tert-Butyl 3-(2-ethoxy-2-oxoethylidene)azetidine-1-carboxylate 95%;3-Ethoxycarbonylmethylene-azetidine-1-carboxylic acid tert-butyl este;1-Azetidinecarboxylic acid, 3-(2-ethoxy-2-oxoethylidene)-, 1,1-dimethylethyl ester
• CAS NO: 1002355-96-5
• Molecular Formula: C₁₂H₁₉NO₄
• Molecular Weight: 241.28356
• Mol File: 1002355-96-5.mol

Chemical Properties

• Boiling Point: 319.5±35.0 °C(Predicted)
• Flash Point: >110℃
• Appearance: /
• Density: 1.188
• Refractive Index: n20/D1.474
• Storage Temp.: 2-8°C
• PKA: -1.67±0.20(Predicted)
• CAS DataBase Reference: 3-Ethoxycarbonylmethylene-azetidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Ethoxycarbonylmethylene-azetidine-1-carboxylic acid tert-butyl ester(1002355-96-5)
• EPA Substance Registry System: 3-Ethoxycarbonylmethylene-azetidine-1-carboxylic acid tert-butyl ester(1002355-96-5)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1002355-96-5(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
3-Ethoxycarbonylmethylene-azetidine-1-carboxylic acid tert-butyl ester is used as a building block for the synthesis of thia and oxa-azaspiro[3.4]octanes. Its reactivity with dipolarophiles allows for the formation of a series of small-ring spirocycles, which are important in various chemical applications.
Used in Pharmaceutical Research:
In the Carreira lab, this compound has been reported to be a valuable precursor in the development of novel pharmaceutical agents. The small-ring spirocycles generated from its [3+2] cycloadditions with dipolarophiles may exhibit unique biological activities, making them potential candidates for drug discovery and development.
Used in Chemical Research:
3-Ethoxycarbonylmethylene-azetidine-1-carboxylic acid tert-butyl ester is also utilized in chemical research to explore the properties and reactivity of small-ring spirocycles. This knowledge can contribute to the advancement of synthetic chemistry and the development of new materials and compounds with specific applications in various industries.

Upstream product

• 398489-26-4 tert-butyl 3-oxoazetidine-1-carboxylate 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Downstream Products

• 1160502-17-9 tert-butyl 3-(3-bromophenyl)-3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate 
• 1173273-89-6 C₁₉H₂₇NO₅ 
• 1173273-96-5 C₁₉H₂₇NO₄ 
• 1173273-92-1 C₁₈H₂₆N₂O₄ 
• 1173274-02-6 C₁₈H₂₅NO₄ 
• 1173273-94-3 C₁₈H₂₄N₂O₆ 
• 1173273-93-2 tert-butyl 3-(2-ethoxy-2-oxoethyl)-3-(4-hydroxyphenyl)azetidine-1-carboxylate 
• 1173273-95-4 C₂₀H₂₇NO₅ 
• 1453861-84-1 2-(3-(4-((4'-(isopropylthio)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid 
• 1453862-34-4 tert-butyl 3-(4-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)-3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate 
• 1453315-68-8 C₁₁H₁₇NO₃S 
• 1453315-62-2 C₁₉H₂₆N₂O₆S 
• 1453315-76-8 tert-butyl 7-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide 
• 1453315-78-0 C₁₁H₁₉NO₅S 

Relevant articles and documents

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