- FRET-based rhodamine-coumarin conjugate as a Fe3+ selective ratiometric fluorescent sensor in aqueous media
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Abstract In this study, a novel ratiometric fluorescent sensor (HL) for Fe3+ based on the conjugation of rhodamine and coumarin has been designed and synthesized. The free sensor displays fluorescence emission at 475 nm, on the addition of Fe3+ to an aqueous solution of HL, the sensor shows significant fluorescence enhancement at 550 nm which should be attributed to an intramolecular fluorescence resonance energy transfer (FRET) mechanism from coumarin to Rhodamine 6G.
- Qin, Jing-Can,Yang, Zheng-Yin,Wang, Guan-Qun,Li, Chao-Rui
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- A novel schiff base fluorescent probe based on coumarin and benzothiazole for sequential detection of Al3+ and PPi and its applicability in live cell imaging
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In this study, a novel schiff base fluorescent probe (E)-N'-(3-(benzo[d]thiazol-2-yl)-2-hydroxy-5-methylbenzylidene)-7-(diethylamino)-2-oxo-2H-chromene-3-carbohydrazide (CHS) was synthesized for sequential detection of Al3+ and pyrophosphate ions (PPi) in a DMSO/HEPES (4:1 v/v, pH = 7.4) buffer system and characterized by 1H NMR, 13C NMR, ESI-HR-MS and DFT calculation. Its detection limit was determined to be 0.16 μM for Al3+ and 0.18 μM for PPi in a pH range of 4～8, respectively. The Job’ s plot showed that the stoichiometric ratio to Al3+ was 1:1, and CHS-Al3+ showed highly selective recognition of PPi. The sensor CHS could also recognize Al3+ and PPi and exhibited fluorescence enhancement and quenching properties in HeLa cells.
- Cao, Duanlin,Han, Xinghua,Hu, Zhiyong,Li, Shengling,Li, Zhichun,Ma, Wenbing,Meng, Xianjiao,Yuan, Changchun,Zhou, Tao
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- Synthesis of a fluorogenic probe for thiols based on a coumarin schiff base copper complex and its use for the detection of glutathione
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Glutathione is the most abundant non-protein thiols compound in cells and plays important metabolic roles. Changes in the amount of glutathione or its metabolic dysregulation can lead to a series of diseases. The determination of glutathione levels is very helpful to the diagnosis and treatment of the related diseases. A coumarin schiff base (compound 1) was synthesized from coumarin hydrazide and 2,6-pyridine dicarboxaldehyde and the fluorogenic probe for thiols (compound 1-Cu2+) was prepared by coordinating compound 1 with copper ions. Compound 1 showed strong fluorescence, while compound 1-Cu2+hardly had fluorescence due to the paramagnetism and/or photoinduced electron transfer of Cu2+. However, after the addition of thiols-containing compounds, the fluorescence of compound 1 was restored. The UV–vis absorption and fluorescence spectra indicated that the fluorogenic probe had good thiols selectivity and sensitivity, particularly for glutathione in CH3CN:HEPES (3:2, v/v) buffer. It was successfully applied to the fluorescence imaging detection of glutathione in human cervical squamous cancer cells (SiHa cells).
- He, Guangjie,Li, Jing,Wang, Zhongquan,Liu, Chenxi,Liu, Xiangli,Ji, Liguo,Xie, Chenyan,Wang, Qingzhi
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- Synthesis and application of a highly selective copper ions fluorescent probe based on the coumarin group
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A highly selective copper ions fluorescent probe based on the coumarin-type Schiff base derivative 1 (probe) was produced by condensation reaction between coumarin carbohydrazide and 1H-indazole-3-carbaldehyde. The UV–vis spectroscopy showed that the maximum absorption peak of compound 1 appeared at 439 nm. In the presence of Cu2 + ions, the maximum peak decreased remarkably compared with other physiological important metal ions and a new absorption peak at 500 nm appeared. The job's plot experiments showed that complexes of 1:2 binding mode were formed in CH3CN:HEPES (3:2, v/v) solution. Compound 1 exhibited a strong blue fluorescence. Upon addition of copper ions, the fluorescence gradually decreased and reached a plateau with the fluorescence quenching rate up to 98.73%. The detection limit for Cu2 + ions was estimated to 0.384 ppm. Fluorescent microscopy experiments demonstrated that probe 1 had potential to be used to investigate biological processes involving Cu2 + ions within living cells.
- He, Guangjie,Liu, Xiangli,Xu, Jinhe,Ji, Liguo,Yang, Linlin,Fan, Aiying,Wang, Songjun,Wang, Qingzhi
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- Rapid Optical Determination of Enantiomeric Excess, Diastereomeric Excess, and Total Concentration Using Dynamic-Covalent Assemblies: A Demonstration Using 2-Aminocyclohexanol and Chemometrics
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Optical analysis of reaction parameters such as enantiomeric excess (ee), diastereomeric excess (de), and yield are becoming increasingly useful as assays for differing functional groups become available. These assays typically exploit reversible covalent or noncovalent assemblies that impart optical signals, commonly circular dichroism (CD), that are indicative of the stereochemistry and ee at a stereocenter proximal to the functional group of interest. Very few assays have been reported that determine ee and de when two stereocenters are present, and none have targeted two different functional groups that are vicinal and lack chromophores entirely. Using a CD assay that targets chiral secondary alcohols, a separate CD assay for chiral primary amines, a UV-vis assay for de, and a fluorescence assay for concentration, we demonstrate a work-flow for speciation of the enantiomers and diastereomers of 2-Aminocyclohexanol as a test-bed analyte. Because of the fact the functional groups are vicinal, we found that the ee determination at the two stereocenters is influenced by the adjacent center, and this led us to implement a chemometric patterning approach, resulting in a 4% absolute error in full speciation of the four stereoisomers. The procedure presented herein would allow for the total speciation of around 96 reactions in 27 min using a high-Throughput experimentation routine. While 2-Aminocyclohexanol is used to demonstrate the methods, the general workflow should be amenable to analysis of other stereoisomers when two stereocenters are present.
- Herrera, Brenden T.,Moor, Sarah R.,McVeigh, Matthew,Roesner, Emily K.,Marini, Federico,Anslyn, Eric V.
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- Fluorescence chemosensor properties of two coumarin-based compounds for environmentally and biologically important Al3+ ion
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In this study, two novel coumarin-based compounds called 2-Acetylpyrazine (coumarin-3′-formyl) hydrazone (1) and 2-Acetylpyrazine (7′-diethylaminocoumarin-3′-formyl) hydrazone (2) have been designed, synthesized and characterized. Compound 1 showed higher selectivity and sensitivity for Al3+ over other environmentally and biologically important metal ions than compound 2, and a remarkable enhancement of compound 1 in fluorescence emission intensity at 486?nm with a large red-shift was observed in the presence of Al3+. This phenomenon was attributed to the inhibition of the photoinduced electron-transfer (PET) process upon complexation of 1 with Al3+. Thus, compound 1 could be used as a fluorescent sensor for Al3+.
- Li, Chao-rui,Qin, Jing-can,Wang, Bao-dui,Bai, Xue,Yang, Zheng-yin
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- Synthesis and application of a “turn on” fluorescent probe for glutathione based on a copper complex of coumarin hydrazide Schiff base derivative
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Discrimination and quantification of intracellular biothiols, such as cysteine (Cys), homocysteine (Hcy), glutathione (GSH) under physiological conditions is significant for academic research and disease diagnosis. A new fluorescent probe (complex 1-Cu2+) for discriminate detection of GSH was prepared by copper ions coordinate with coumarin carbohydrazide Schiff base derivative 1. In suitable buffer solution (CH3CN: HEPES = 3:2, v/v) and under appropriate pH condition (pH = 7.2–7.4), the UV–vis spectroscopy experiments showed that compound 1 and copper ion exhibited a 1:1 ratio binding mode and moderate binding ability. Fluorescence quenching of compound 1 was observed when it complexed with Cu2+ ions. An obviously fluorescence restoration appeared after addition of GSH to the solution of probe, which also exhibited a highly selectivity relative to cysteine (Cys) and homocysteine (Hcy) in the amino acid competitive experiments. The minimum detection limit was calculated to 0.12 μM by fluorescent method, which was distinctly below the physiological concentration of GSH in live cells. Its biological application to detect the endogenous GSH was further proved by the HepG2 cell fluorescence image test.
- He, Guangjie,Hua, Xiaobo,Yang, Nan,Li, Linlin,Xu,Yang, Linlin,Wang, Qingzhi,Ji
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- A diarylethene derived Fe3+ fluorescent chemosensor and its application in wastewater analysis
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A diarylethylene derivative containing an acylhydrazone Schiff base moiety was designed and synthesized. Upon alternative irradiation with UV and visible lights, the compound showed distinct fluorescence switching properties based on fluorescence resonance energy transfer mechanism. On the other hand, the fluorescence can be efficiently quenched by 69 fold in the presence of Fe3+ ion in methanol. As a Fe3+ fluorescent chemosensor, the sensing mechanism, the influence of pH on sensing properties, and the practical application were also studied. In the complex, the breaking of the intramolecular H-bonding between the –CO [dbnd] NH– proton and the oxygen at the C[dbnd] O of lactone, the weaking of electrons transfer, and the paramagnetic nature of Fe3+ induced a consequent decrease fluorescence. The compound was found to be stable in a wide range of pH and a highly efficient Fe3+ ion quencher with a detection limit of 4.6 × 10?6 mol L?1. Moreover, the fluorescent detection of Fe3+ was demonstrated by filter paper strips. A series of test papers with different Fe3+ concentrations were prepared and used as the standard card. The analytical application of measuring Fe3+ concentration in wastewater samples were evaluated by comparison with the standard card directly and quickly.
- Li, Yongjie,Pan, Wenhao,Zheng, Chunhong,Pu, Shouzhi
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- An acylhydrazone coumarin as chemosensor for the detection of Ni2+ with excellent sensitivity and low LOD: Synthesis, DFT calculations and application in real water and living cells
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A novel acylhydrazone coumarin fluorescent chemosensor C4 for detection of Ni2+ was designed and synthesized. The experimental results revealed a low detection limit of 2.1 × 10?11 M with high selectivity and excellent sensitivity towards Ni2+. C4 showed a good linear relationship with the concentration of Ni2+ from 1.3 × 10?6 to 1.6 μM. Moreover, a stable complex was formed between C4 and with Ni2+ and the binding ratio was proved to be 2: 1 by Job's plot and mass spectrum. The sensing ability of C4 towards Ni2+ was attributed to parity-forbidden transition according to fluorescence titrations and DFT calculations. The detection of Ni2+ in water samples illustrated C4 could be successfully applied for the detection of Ni2+ in real environmental samples. What's more, the fluorescence microscopy images of Hela cells demonstrated the high potential of the novel biosensor for the investigation of biological processes involving Ni2+, as well.
- Chen, Jichao,Gao, Buhong,Jiang, Weina,Li, Zhong,Lu, Wen,Shi, Jiuzhou,Xu, Li,Yang, Shilong
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- A chromone derivative as a colorimetric and “ON-OFF-ON” fluorescent probe for highly sensitive and selective detection of Cu2+ and S2?
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A chromone derivative (L) which could be utilized for reversibly detecting Cu2+ and S2? by means of fluorescence quenching and displacement in aqueous solution was designed and developed. Upon the addition of Cu2+, the strong blue-green fluorescence emission of L was quenched rapidly and then recovered in 1 min by successively adding S2?. Furthermore, with the alternate addition of Cu2+ and S2?, the reversible cycles could be repeated for at least four times, which meant that L could be identified as a renewable dual-functioning probe. What's more, due to its excellent sensing performances, this probe L could also be used to detect Cu2+ and S2? with test strips conveniently.
- Liu, Cong,Tian, Limei,Liu, Kui,Xue, Jia,Fan, Long,Li, Tianrong,Yang, Zheng-yin
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- A novel ratiometric fluorescent probe based on coumarin derivative for the recognition of Al(III) and its application on test strips
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A novel ratiometric probe (L) which was composed of chromone and coumarin moieties has been designed and synthesized for sensing Al3+ in EtOH in view of the internal charge transfer (ICT) mechanism. The free probe L exhibited a strong fluorescence emission at 477 nm, and the fluorescence emission here almost disappeared after adding Al3+ (10 equiv.) while a new peak appeared at 524 nm. This may be due to the enhancement of intramolecular electron transfer efficiency from donor to acceptor. In addition, this probe L could be form a 1:1 complex with Al3+, which could be explained by the ESI-MS spectra, and L had a low detection limit for Al3+ with a binding constant of 1.32 × 104 M?1. More importantly, L could be applied to a solid probe for rapid detection of Al3+ with a significant color change.
- Xue, Jia,Tian,Yang, Zheng-yin
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- A highly sensitive and selective chemosensor for Pb2+ based on quinoline-coumarin
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In this study, a highly sensitive and selective fluorescent chemosensor, ethyl(E)-2-((2-((2-(7-(diethylamino)-2-oxo-2H-chromene-3-carbonyl)hydrazono)methyl)quinolin-8-yl)oxy)acetate (1), was synthesized and characterized by 1H NMR, 13C NMR and ESI-MS. Sensor 1 showed an “on-off” fluorescence response to Pb2+ with a 1?:?1 binding stoichiometry in CH3CN/HEPES buffer medium (9?:?1 v/v). The detection limit of sensor 1 to Pb2+ was determined to be 0.5 μM, and the stable pH range for Pb2+ detection was from 4 to 8.
- Meng, Xianjiao,Cao, Duanlin,Hu, Zhiyong,Han, Xinghua,Li, Zhichun,Ma, Wenbing
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- A turn-on fluorescent probe based on quinoline and coumarin for rapid, selective and sensitive detection of hypochlorite in water samples
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A fluorescent probe L-Cu2+ based on quinoline, coumarin and Cu2+ has been synthesized and characterized for hypochlorite determination. After copper ion was added to the solution of ligand L, the fluorescence quenching at 490 nm might result from a ligand–metal charge transfer (LMCT) process and its strong coordination ability for Cu2+. In the presence of hypochlorite, the structure of ligand L was destroyed to form 7-(diethylamino)-coumarin-3-carboxylic acid, and the fluorescence was restored at 460 nm. In this case, L-Cu2+ complex could be used as a fluorescent probe to detect hypochlorite, with the advantages of rapid, selective, wide linear range and low detection limit.
- Liu, Ruxin,Zhao, Yuqi,Cui, Xiaoqian,Sun, Xiaoxiao,Fei, Qiang,Feng, Guodong,Shan, Hongyan,Huan, Yanfu
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- Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactate transport inhibitors
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As an oncometabolite, lactate plays a very important role in tumor proliferation, metastasis, angiogenesis, immune escape and other tumor biological functions. Pharmacological inhibition of lactate transport has been viewed as a promising therapeutic strategy to target a range of human cancers. In this study, a series of new coumarin-3-carboxylic acid derivatives 5a-t and 9a-b were synthesized and evaluated as lactate transport inhibitors. Their cytotoxic activity has been tested against three cell lines high-expressing and low-expressing monocarboxylate transporter 1 (MCT1) which acts as the main carrier for lactate. Compound 5c-e, 5g-i and 5m-o showed significant cytotoxicity and good selectivity against Hela and HCT116 cell lines with high MCT1 expression. Notably, coumarin-3-hydrazide 5o, the lead molecule with the most potent cytotoxic activity, exhibited significant anti-proliferation and apoptosis induction effects. Further studies revealed that compound 5o decreased the expression level of target MCT1, and suppressed the energetic metabolism of Hela and HCT116 cells by remarkably reducing glucose consumption and lactate production. Additionally, compound 5o induced intracellular lactate accumulation and inhibited lactate uptake, which implied that it blocked lactate transport via MCT1. These results indicate a good start point for the development of lactate transport inhibitors as new anticancer agents.
- Ji, Hong,Tan, Yaling,Gan, Nana,Zhang, Jing,Li, Shannuo,Zheng, Xuan,Wang, Zhaohua,Yi, Wei
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- Coumarin-based palladium ion fluorescent probe compound and preparation method thereof
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The invention discloses a coumarin-based palladium ion fluorescent probe compound and a preparation method thereof, and belongs to the technical field of organic small molecule fluorescent probes. The palladium ion fluorescent probe compound has a structural formula shown in the specification. The preparation method comprises the following steps of: adding diethyl malonate, glacial acetic acid and piperidine into an ethanol solution of a compound 1, namely 4-(diethylamino)-salicylaldehyde, purifying, adding hydrazine hydrate, heating and the like. The prepared palladium ion probe is in a fluorescence enhancement mode and is high in sensitivity, and the detection limit is as low as 4.45*10. The probe shows high selectivity to palladium ions and strong anti-interference performance.
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- Compound capable of emitting white light and preparation method thereof
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The invention discloses a compound capable of emitting white light and a preparation method thereof, and belongs to the technical field of rare earth complexes, organic chemistry and material chemistry. The preparation method comprises the following steps of: reacting an ethanol solution of coumarin ester with hydrazine hydrate according to a reasonable ratio to obtain a compound 1, dissolving the compound 1 and 8-hydroxy-2-quinolinaldehyde in ethanol for reaction to obtain a compound CRP4, and reacting an ethanol solution of the compound CRP4 with an ethanol solution of Eu (TTA) 3 (H2O) 2 to obtain a compound CRP4-Eu. The compound has the beneficial effects that single-molecule white light emission is realized through blue light emission of a coumarin derivative part and red light emission of a rare earth europium complex, a foundation is laid for application of the coumarin derivative part as a single-molecule white light material in the future, and the white light material can be used as a liquid crystal backlight source and solid-state illumination and is wide in application prospect.
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Paragraph 0021-0024
(2021/10/16)
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- Hypochlorite responsive even hydrazide connecting key and application thereof
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The invention discloses a hypochlorite responsive even hydrazide connecting key and application thereof. A structural formula of the connecting key is (with the reference to the specification); the connecting key is prepared from an R1 parent containing reactive carbonyl and an R2 parent containing reactive carbonyl by a reaction with hydrazine hydrate; the reactive carbonyl can be ester, carboxylic acid, acyl chloride, aldehyde or cyclic ketone. The connecting key can react with specificity of OCl, is oxidized and cut off by OCl to form carboxyl so as to distinguish OCl in ROS, has high specificity, and can be widely used in various fields of hypochlorite response, such as a hypochlorite fluorescent probe, a hypochlorite responsive drug carrier, a hypochlorite responsive nano probe, a prodrug for treating ROS related diseases, a carrier with double effects of diagnosis and treatment and the like.
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- Novel coumarin Schiff base derivative and preparation method thereof as well as application thereof in copper ion fluorescence and cell imaging detection
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The invention discloses a novel coumarin Schiff base derivative and a preparation method thereof as well as application thereof in copper ion fluorescence and cell imaging detection, and belongs to the synthesis technical field of copper ion fluorescence probes. According to the technical scheme adopted by the invention, the key point is that the novel coumarin Schiff base derivative has a structural formula shown in the specification. The invention further discloses a preparation method of the novel coumarin Schiff base derivative and application thereof in copper ion fluorescence and cell imaging detection. The fluorescence probe further can be used for identifying copper irons with high selectivity, and is basically free of interference on detection while other common ions coexist with the copper ion. On the basis, a Leica DMI8 inverted fluorescence microscope is applied to realize cell fluorescence imaging on copper ions by the fluorescence probe in liver cancer HepG-2 cells, so that a quick, simple, convenient and sensitive copper ion detecting method with high selectivity is established.
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- Multifunctional imaging probe for detecting copper ions and synthesis method of multifunctional imaging probe
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The invention belongs to the field of biological detection and particularly relates to a kind of multifunctional imaging molecular probes detecting copper ions by using fluorescent imaging and magnetic resonance imaging. The probe has the following structural general formula (please see the formula in the specification). The probe is synthesized based on fluorescein and DTPA, firstly, coumarin serves as a raw material, the coumarin and ten-fold hydrazine hydrate are subjected to a stirring reaction in ethanol, and yellow solids are obtained; and then in a dimethylformamide solution, the yellow solids and diethylenetriamine pentaacetic acid dianhydride are further subjected to a heating reaction, drying under reduced pressure is performed, an obtained product and gadolinium nitrate or europium nitrate are stirred in a methanol solution at room temperature to stay overnight, and drying under reduced pressure is performed so that a target product can be obtained. Probe molecules have good chemical and light stability and sensitivity, the probe molecules have high selectivity on the copper ions and are not interfered by metal ions in other living organisms, high-sensitivity fluorescent imaging and high-spatial-resolution magnetic resonance imaging of the copper ions can be achieved, and advantages of two kinds of imaging manners are complemented.
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Paragraph 0020; 0021; 0022
(2017/08/26)
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- Coumarin schiff-base copper ion complex-based fluorescent probe for thiol as well as preparation method and application thereof
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The invention discloses a coumarin schiff-base copper ion complex-based fluorescent probe for thiol as well as a preparation method and an application thereof. Coumarin hydrazide and 2,6-pyridinedicarboxaldehyde are used as raw materials for synthesis of a coumarin schiff-base derivative (a compound 1), the compound 1 and copper ions are coordinated in order to form the coumarin-copper ion complex with a schiff-base structure, and the compound 1-Cu is obtained. The probe ensures fluorescence quenching of the compound 1 due to influences of paramagnetism and chelation of Cu. When thiol-containing amino acids are added, fluorescence of the compound 1-Cu is enhanced. Other amino acids which do not contain thiols do not influence the fluorescence effects. UV-visible spectrum absorption and fluorescence spectrum show that the compound 1-Cu has good selectivity and sensitivity for thiol-containing amino acids in a CH3CN:HEPES(3:2,v/v) solution. The probe was successful to be applied to SiHa cells, and was used for carrying out cell imaging experiments of glutathione. The method is hopeful to be applied to detection of thiol compounds in organisms.
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- Preparation method and application of mercaptan fluorescence probe based on coumarin
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The invention discloses a preparation method and application of a mercaptan fluorescence probe based on coumarin. The preparation method includes: coumarin and p-tert-butylphenol dialdehyde are used as raw materials to synthesize a bis-Schiff base coumarin derivative (compound I), the compound I has strong fluorescence, and the compound I is coordinated with copper ions to prepare coumarin-copper ion (II) complex, namely the mercaptan fluorescence probe I-Cu (II). Due to the influence of the paramagnetism of Cu2+ and photoinduction electron transfer effect, the fluorescence of the compound I is quenched; sulfur atoms in compounds such as mercapto-amino acid and derivatives such as glutathione thereof and Cu2+ have a strong coordination effect, the competitive coordination effect allows the copper ions in the coumarin-copper ion (II) complex to be taken away by the mercapto-amino acid and the derivatives thereof so as to regenerate the compound I, and the fluorescence of the compound I is restored. Accordingly, a method for fast and simply detecting mercaptan compounds is built.
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- A fluorescent probe for hypochlorite based on the modulation of the unique rotation of the N-N single bond in acetohydrazide
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Herein, a novel signaling mechanism for constructing fluorescent probes was demonstrated for the first time based on modulation of the unique rotation of the N-N single bond in the acetohydrazide group. According to the new signaling mechanism, a fluorescent probe for hypochlorite was then judiciously developed.
- Long, Lingliang,Wu, Yanjun,Wang, Lin,Gong, Aihua,Hu, Feilong,Zhang, Chi
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p. 10435 - 10438
(2015/06/25)
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- A ditopic fluorescence sensor for saccharides and mercury based on a boronic-acid receptor and desulfurisation reaction
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Two boron-contained fluorescent sensors, 1 and 2, based on coumarin have been prepared. The fluorescence response of the two systems was investigated with addition of saccharide and mercury ions. Sensor 2 behaves as a bifunctional fluorescent switch with chemical inputs of D-fructose and mercury ions.
- Xing, Zhitao,Wang, Hui-Chen,Cheng, Yixiang,James, Tony D.,Zhu, Chengjian
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p. 3054 - 3058
(2012/06/30)
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- A Hg2+-selective chemodosimeter based on desulfurization of coumarin thiosemicarbazide in aqueous media
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A fluorescence-enhanced chemodosimeter 1 based on coumarin thiosemicarbazide for Hg2+ was developed via a Hg2+-induced desulfurization reaction. Spectroscopic results reveal that chemodosimeter 1 exhibits high sensitivity and selectivity for Hg2+ in comparison to common interfering metal ions in aqueous media at room temperature.
- Ma, Wenhui,Xu, Qun,Du, Jianjun,Song, Bo,Peng, Xiaojun,Wang, Zhuo,Li, Guodong,Wang, Xifang
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experimental part
p. 248 - 252
(2010/08/06)
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- Screening search for organic fluorophores: Syntheses and fluorescence properties of 3-azolyl-7-diethylaminocoumarin derivatives
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In order to find a highly sensitive fluorophore, 3-azolyl-7-diethylaminocoumarin derivatives were synthesized. Both the absorption and fluorescence maxima of the coumarin-thiazole compounds showed red shifts with increases of the molar absorptivities and fluorescence intensities, in comparison with those of the corresponding coumarin-oxazole compounds. Among them, 3-(5-ethoxycarbonyl-1,3-thiazol-2-yl)-7-diethylamino-2H-chromen-2-one (3e) was one of the most promising candidates as a fluorophore accessible for analytical purposes in the fields of analytical and biological chemistry.
- Takechi,Oda,Nishizono,Oda,Machida
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p. 1702 - 1710
(2007/10/03)
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