- ISOTHIAZOLOPYRIMIDINONES, PYRAZOLOPYRIMIDINONES, AND PYRROLOPYRIMIDINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS
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The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.
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- Nematicidal isothiazole derivatives
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Nematicidal 3-aryl-4-amino-5-isothiazole acids, esters and amides of the formula STR1 wherein A is selected from hydroxy, alkoxy, phenylmethoxy, and --NHR, where R is hydrogen, alkyl, 2-hydroxyethyl or 2-acetyloxyethyl; and Z is selected from hydrogen, ha
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