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100365-95-5

Hemoglobin F Shanghai, also known as HbF Shanghai, is a rare variant of fetal hemoglobin characterized by a unique genetic mutation found predominantly in individuals of Chinese descent. This variant arises from a missense mutation in the γ-globin gene, resulting in elevated levels of fetal hemoglobin in red blood cells compared to the typical adult hemoglobin. The presence of Hemoglobin F Shanghai has been associated with a protective effect against certain inherited blood disorders, such as sickle cell disease and beta-thalassemia, due to its capacity to mitigate the severity of symptoms related to these conditions.

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  • 100365-95-5 Structure

  • Basic information

    1. Product Name: hemoglobin F Shanghai
    2. Synonyms: hemoglobin F Shanghai
    3. CAS NO:100365-95-5
    4. Molecular Formula:
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 100365-95-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: hemoglobin F Shanghai(CAS DataBase Reference)
    10. NIST Chemistry Reference: hemoglobin F Shanghai(100365-95-5)
    11. EPA Substance Registry System: hemoglobin F Shanghai(100365-95-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 100365-95-5(Hazardous Substances Data)

100365-95-5 Usage

Uses

Used in Medical Applications:
Hemoglobin F Shanghai is utilized as a potential therapeutic agent for the treatment of inherited blood disorders, specifically sickle cell disease and beta-thalassemia. Its protective effect is attributed to its ability to reduce the severity of symptoms associated with these conditions, offering a promising avenue for further research and development in the medical field.
Used in Research Applications:
Hemoglobin F Shanghai serves as a valuable subject for scientific research, particularly in the study of genetic mutations and their impact on hemoglobin function. Understanding the implications of this rare hemoglobin variant can contribute to the advancement of knowledge in molecular biology, genetics, and the development of targeted therapies for blood-related disorders.
Used in Drug Development:
Hemoglobin F Shanghai may be employed as a target for the development of new drugs or therapies aimed at treating or managing the symptoms of sickle cell disease and beta-thalassemia. Its unique properties and protective effects could inspire the creation of novel treatment strategies that leverage the benefits of this rare variant.

Check Digit Verification of cas no

The CAS Registry Mumber 100365-95-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,3,6 and 5 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 100365-95:
(8*1)+(7*0)+(6*0)+(5*3)+(4*6)+(3*5)+(2*9)+(1*5)=85
85 % 10 = 5
So 100365-95-5 is a valid CAS Registry Number.

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