Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
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Page/Page column 12
(2010/06/11)
Semisynthesis, biological activity, and molecular modeling studies of C-ring-modified camptothecins
The synthesis, biological activity, and molecular modeling studies of C-ring-modified camptothecins are reported. A general synthetic protocol, based on "C-5 camptothecin (C-5-CPT) enolate chemistry", allows one to obtain various C5-substituted analogues.
5-substituted camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
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(2008/06/13)
CAMPTOTHECIN DERIVATIVES WITH ANTITUMOR ACTIVITY
Novel camptothecin derivatives of Formula (I) having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
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Page/Page column 10-11
(2008/06/13)
CAMPTOTHECIN DERIVATIVES WITH ANTITUMOR ACTIVITY
5-Substituted thio-camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
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Page/Page column 27-28
(2008/06/13)
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