- A 2- martonite base -3-methoxy-1-piperidine carboxylic acid ethyl ester preparation method
-
The invention discloses a preparation method for ethyl 2-bromoacetonyl-3-methoxy-1-piperidinecarboxylate. The preparation method comprises the following steps: using a bromination reagent to have a substitution reaction with 2-acetonyl-3-methoxypiperidine, so as to generate 2-bromoacetonyl-3-methoxy-1-piperidine, then reacting 2-bromoacetonyl-3-methoxy-1-piperidine with ethyl chloroformate, so as to synthesize ethyl 2-bromoacetonyl-3-methoxy-1-piperidinecarboxylate. The bromination reagent employed in the method is relatively good in activity and selectivity, and substitution reaction can be performed in a medium polar solvent, so that the reaction difficulty is substantially reduced and the reaction yield is improved. Also the bromination reagent is friendly to environment, does not cause environmental pollution, is cheap and easily available, and helps to substantially reduce cost.
- -
-
Paragraph 0041; 0043
(2017/02/24)
-